The COVID-19 virus is a β-genus virus that causes infection by mediating the angiotensin convertible enzyme 2 (ACE2) receptor, which is distributed in large numbers in the human respiratory tract.
Dong Ok Choi, Kang Moon Lee
doaj +1 more source
Statistical thermodynamics of the binding energy super-landscape in the adaptive immune system [PDF]
The humoral adaptive immune system, from the physical perspective, can be regarded as a self-organized antibody binding energy landscape. In biological terms, the system organizes its repertoire of antigen binding molecules so as to maintain its molecular integrity.
arxiv
Photonic Crystal Enhanced Microscopy on a 2D Photonic Crystal Surface
This work demonstrates the design, fabrication, and the first‐time test of a 2D photonic crystal surface for photonic resonator absorption microscopy. The designed surface uniformly enhances electromagnetic near fields, achieving > 100% improved detecting uniformity for surface‐captured AuNPs from a blocking biosensor assay aimed for detecting SARS‐CoV‐
Weinan Liu+5 more
wiley +1 more source
Detection of Influenza A Virus Nucleoprotein Through the Self-Assembly of Nanoparticles in Magnetic Particle Spectroscopy-Based Bioassays: A Method for Rapid, Sensitive, and Wash-free Magnetic Immunoassays [PDF]
Magnetic nanoparticles (MNPs) with proper surface functionalization have been extensively applied as labels for magnetic immunoassays, carriers for controlled drug/gene delivery, tracers and contrasts for magnetic imaging, etc. Here, we introduce a new biosensing scheme based on magnetic particle spectroscopy (MPS) and the self-assembly of MNPs to ...
arxiv
Quantum Optical Immunoassay: Upconversion Nanoparticle-based Neutralizing Assay for COVID-19 [PDF]
In a viral pandemic, a few important tests are required for successful containment of the virus and reduction in severity of the infection. Among those tests, a test for the neutralizing ability of an antibody is crucial for assessment of population immunity gained through vaccination, and to test therapeutic value of antibodies made to counter the ...
arxiv
A novel approach enables facile and reproducible fabrication of gold nanoparticle arrays with tunable near‐infrared plasmonic properties and enhanced sensing accuracy. Using advanced lithography and ion milling, combined with innovative surface chemistry, the approach minimizes ohmic losses and non‐specific sorption, improving biomolecular detection ...
Dario Cattozzo Mor+12 more
wiley +1 more source
Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis [PDF]
Introduction: The incidence of death among patients admitted for severe sepsis or septic shock is high. Adrenomedullin (ADM) plays a central role in initiating the hyperdynamic response during the early stages of sepsis.
Bergmann A+5 more
core +1 more source
A Novel High-Throughput and Sensitive Electrochemiluminescence Immunoassay System
(1) Background: In vitro diagnostic (IVD) tests are the main means of obtaining diagnostic information for clinical purposes. The electrochemiluminescence immunoassay (ECLIA) has become an important in vitro diagnostic technique. It has unique advantages
Xiancheng Liu+11 more
doaj +1 more source
SpotNet - Learned iterations for cell detection in image-based immunoassays [PDF]
Accurate cell detection and counting in the image-based ELISpot and FluoroSpot immunoassays is a challenging task. Recently proposed methodology matches human accuracy by leveraging knowledge of the underlying physical process of these assays and using proximal optimization methods to solve an inverse problem.
arxiv
Microfluidic multipoles: theory and applications [PDF]
Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced MFMs is constrained by the lack of simple, accurate models to predict mass transport within them.
arxiv +1 more source