Advanced Science, EarlyView.In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou +10 more
wiley +1 more source
Inverted Pyramid Nanostructures Coupled with a Sandwich Immunoassay for SERS Biomarker Detection
NanomaterialsCancer diagnostics often faces challenges, such as invasiveness, high costs, and limited sensitivity for early detection, emphasizing the need for improved approaches.
Wen-Huei Chang +3 more
doaj +1 more source
PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites
Advanced Science, EarlyView.This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang +13 more
wiley +1 more source
Detection and quantification of gluten as allergen in whisky samples by validated immunoassay method [PDF]
, 2022 Amartya Kumar Gupta, Nandita Das
openalex +1 more source
KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression
Advanced Science, EarlyView.Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao +9 more
wiley +1 more source
Measurement of immunoglobulin A in saliva by particle-enhanced nephelometric immunoassay: sample collection, limits of quantitation, precision, stability and reference range [PDF]
, 2009 Christine Booth +3 more
openalex +1 more source
ODP178 Development and Validation of a Noncompetitive Immunoassay Optimized for the Assessment of Pharmacokinetics of Biologically Active Efruxifermin in Humans [PDF]
, 2022 Jacob Hurst +5 more
openalex +1 more source
Parabiosis, Assembloids, Organoids (PAO)
Advanced Science, EarlyView.This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong +5 more
wiley +1 more source
Identification, partial characterization, and use of grey mullet (Mugil cephalus) vitellogenins for the development of ELISA and biosensor immunoassays [PDF]
, 2019 Paolo Cocci +7 more
openalex +1 more source
Electrochemiluminescence Drives Photodynamic Therapy In Vivo
Advanced Science, EarlyView.Electrochemiluminescence (ECL)‐driven photodynamic therapy (PDT) for in vivo cancer treatment is reported for the first time. The flexible ECL patch exhibits stable and intense luminance under alternating current voltage, enabling efficient photosensitization to generate reactive oxygen species that damage cancer cells, thus leading to significant ...
Jia‐Bao Lin +5 more
wiley +1 more source