Results 11 to 20 of about 1,013 (170)

Biotechnological Evolution of siRNA Molecules: From Bench Tool to the Refined Drug

Pharmaceuticals, 2022
The depth and versatility of siRNA technologies enable their use in disease targets that are undruggable by small molecules or that seek to achieve a refined turn-off of the genes for any therapeutic area.
Danielle de Brito e Cunha, Ana Beatriz Teixeira Frederico, Tamiris Azamor, Juliana Gil Melgaço, Patricia Cristina da Costa Neves, Ana Paula Dinis Ano Bom, Tatiana Martins Tilli, Sotiris Missailidis   +7 more
doaj   +1 more source

Immunobiology of cholangiocarcinoma [PDF]

JHEP Reports, 2019
Cholangiocarcinoma (CCA) represents a heterogeneous group of epithelial tumours that are classified according to anatomical location as intrahepatic (iCCA), perihilar (pCCA), or distal (dCCA). Although surgical resection and liver transplantation following neoadjuvant therapy are potentially curative options for a subset of patients with early-stage ...
Emilien Loeuillard, Caitlin B. Conboy, Gregory J. Gores, Sumera Rizvi   +3 more
openaire   +3 more sources

Therapeutic response and survival time of immunobiologicals in patients with moderate to severe psoriasis

Anais Brasileiros de Dermatologia, 2022
Cynthia Cristina Ferreira Mota, Ricardo Romiti, Marcelo Arnone, Andre Luís da Silva Hirayama, Maria Denise Fonseca Takahashi   +4 more
doaj   +3 more sources

Identification of B-Cell Linear Epitopes in the Nucleocapsid (N) Protein B-Cell Linear Epitopes Conserved among the Main SARS-CoV-2 Variants

Viruses, 2023
The Nucleocapsid (N) protein is highlighted as the main target for COVID-19 diagnosis by antigen detection due to its abundance in circulation early during infection.
Rodrigo N. Rodrigues-da-Silva, Fernando P. Conte, Gustavo da Silva, Ana L. Carneiro-Alencar, Paula R. Gomes, Sergio N. Kuriyama, Antonio A. F. Neto, Josué C. Lima-Junior   +7 more
doaj   +1 more source

ANALYSIS OF THE PERSONNEL’S CONSISTENT READINESS FOR CHANGES AS ILLUSTRATED BY THE EXAMPLE OF AN EXPORT-ORIENTED BIOTECHNOLOGICAL ENTERPRISE

Фармация и фармакология (Пятигорск), 2021
The biotechnology industry is currently one of the most dynamically developing sectors of the pharmaceutical industry, that is why it requires improvement in the personnel management system aimed at increasing the flexibility and adaptability of the ...
E. V. Kazakova, V. P. Trukhin, I. A. Narkevich, I. I. Basakina   +3 more
doaj   +1 more source

Comparability assessment of the results of thiomersal quantification in adsorbed immunobiological medicinal products by colourimetry and by cold vapor atomic absorption spectrometry

Биопрепараты: Профилактика, диагностика, лечение, 2022
To ensure the quality of immunobiologicals, it is required to quantify the thiomersal preservative present in a number of them. The authors have previously developed an analytical procedure for thiomersal quantification in non-adsorbed immunobiological ...
O. N. Kolesnikova, V. E. Tregubova, O. B. Ustinnikova, A. A. Movsesyants   +3 more
doaj   +1 more source

Alternative potency tests for quality control of immunobiologicals: a critical review of the validation approach

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2020
Introduction: In addition to low reproducibility, in vivo potency tests used in the quality control of immunobiological products require too many animals, causing them significant pain and suffering.
Wildeberg Cal Moreira, Nathalia de Souza Machado, Jéssica Ferreira de Souza Freitas, Antônio Eugênio Castro Cardoso de Almeida, Wlamir Correa de Moura   +4 more
doaj   +7 more sources

The immunobiology of cholangiocytes [PDF]

Immunology & Cell Biology, 2008
Cholangiocytes, the epithelial cells lining bile ducts, provide the first line of defense against lumenal microbes in the biliary system. Recent advances in biliary immunity indicate that cholangiocytes express a variety of pathogen‐recognition receptors and can activate a set of intracellular signaling cascades to initiate a profound antimicrobial ...
Xian-Ming, Chen, Steven P, O'Hara, Nicholas F, LaRusso   +2 more
openaire   +2 more sources

Calendário vacinal na infância e adolescência: avaliando diferentes propostas Vaccination schedule for childhood and adolescence: comparing recommendations

Jornal de Pediatria, 2006
OBJETIVOS: Apresentar os critérios utilizados para elaboração de um calendário de vacinação na infância e adolescência, comparando recomendações de instituições de referência em nível nacional e internacional FONTES DOS DADOS: Revisão da literatura ...
Ricardo Becker Feijó, Juarez Cunha, Lenita Simões Krebs   +2 more
doaj   +1 more source

Overdiagnosis of vaccine allergy: Skin testing and challenge at a public specialized unit (CRIE) in Rio de Janeiro, Brazil

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Vaccination is an extremely safe public health intervention, but rare IgE-mediated adverse events must be identified to avoid the risk of anaphylaxis in the event of reexposure.
Luciana Gomes Pedro Brandão, PhD, MSc, MD, Mari Tuyama, PhD, MSc, MD, Flávio de Carvalho, MSc, RN, Ananza Taina da Silva Santos, MSc, RN, Alberto dos Santos de Lemos, MSc, MD, Marcellus Dias da Costa, MSc, MD, Emersom Cicilini Mesquita, PhD, MSc, MD, José Cerbino-Neto, PhD, MSc, MD, Margareth Catoia Varela, MSc, Pedro Emmanuel Alvarenga Americano do Brasil, PhD, MSc, MD, Angélica Varela Rondon, MSc, MD   +10 more
doaj   +1 more source