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Synthesis of an immunoconjugate of camptothecin
Bioorganic & Medicinal Chemistry Letters, 2002The first immunoconjugate of camptothecin has been synthesized wherein the drug is attached to the tumor-recognizing antibody BR96 via a Cathepsin B cleavable linker. Endocytosis of the immunoconjugate upon binding to the tumor cell followed by enzymatic cleavage of the linker inside the endosome ensures tumor-specific release of the drug. In this way,
Michael A, Walker +4 more
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Intraperitoneal immunoconjugates.
Cancer research, 1990Intracavitary instillation of radioantibodies has been proposed as therapy for anatomically confined malignant disease. To evaluate this therapeutic strategy, a monoclonal antibody reactive with human transferrin receptor (7D3) was evaluated for localization in a human malignant mesothelioma transplanted i.p. in athymic nude mice.
T W, Griffin +7 more
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EGFR targeting for cancer therapy: Pharmacology and immunoconjugates with drugs and nanoparticles
International Journal of Pharmaceutics, 2021Jessica Roberta Pereira Martins +2 more
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Targeted Therapy of Cancer: New Prospects for Antibodies and Immunoconjugates
Ca-A Cancer Journal for Clinicians, 2006David M Goldenberg, R M Sharkey
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The development of immunoconjugates for targeted cancer therapy
Nature Reviews Clinical Oncology, 2014Louis Weiner, Weiner Louis M
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Immunoconjugates for Osteosarcoma Therapy: Preclinical Experiences and Future Perspectives
Biomedicines, 2018Andrea Bolognesi +2 more
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