Results 101 to 110 of about 8,578 (238)

p-SCN-Bn-DOTA-Trastuzumab immunoconjugates and vibrational spectroscopy examination [PDF]

open access: yes, 2019
Introduction: Attenuated total reflectance-infrared (ATR-IR) and Raman spectroscopy, as vibrational techniques, provide reliable molecular structure information and are significant for determination of any of changes in the secondary structure.
Janevik-Ivanovska, Emilija   +3 more
core  

immunoconjugate

open access: yes
Citation: 'immunoconjugate' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13279 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

A Reflection on the Evolution of Antibody‐Based Therapies in Oncology: Trastuzumab as an Exemplar—Commentary on Dijkers et al.

open access: yes
Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1577-1587, June 2025.
Sarah A. Holstein
wiley   +1 more source

Cell death triggered by alpha-emitting 213Bi-immunoconjugates in HSC45-M2 gastric cancer cells is different from apoptotic cell death.

open access: yes, 2005
PURPOSE: Radioimmunotherapy with alpha-particle-emitting nuclides, such as 213Bi, is a promising concept for the elimination of small tumour nodules or single disseminated tumour cells.
Seidl, C;Schröck, H;Seidenschwang, S;Beck, R;Schmid, E;Abend, M;Becker, KF;Apostolidis, C;Nikula, TK;Kremmer, E;Schwaiger, M;Senekowitsch-Schmidtke, R
core   +1 more source

A New Type of Modified Brassinosteroids for Enzyme-linked Immunosorbent Assay

open access: yesNatural Product Communications, 2008
New modified brassinosteroids (BS) with a full set of specific functional groups and with an additional one at C-26 have been synthesized and used as haptens for enzyme-linked immunosorbent assay. The haptens were conjugated to bovine serum albumin (BSA)
Vladimir Khripach   +9 more
doaj   +1 more source

Rapid Generation of In Vitro Multicellular Spheroids for the Study of Monoclonal Antibody Therapy

open access: yesJournal of Cancer, 2011
Tumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates and are difficult to study in vitro. Cells cultured as monolayers typically exhibit less resistance to therapy than those grown in vivo.
Yen T. Phung, Dario Barbone, V. Courtney Broaddus, Mitchell Ho
doaj  

Evaluation of non-radioactive lutetium- and yttrium-labeled immunoconjugates of rituximab - a vibrational spectroscopy study

open access: yes, 2015
Fourier Transform Infrared (FT-IR) and Raman Spectroscopy were used to study the molecular structure of the recombinant monoclonal antibody and anti-CD20-conjugates which are intended to be used as anti-cancer therapeutic agents.
Janevik-Ivanovska, Emilija   +5 more
core  

Physico-chemical assessment of labeled freeze dried kits of trastuzumab-immunoconjugates significant for breast cancer therapy [PDF]

open access: yes, 2018
Introduction: Monoclonal antibodies appears as an important therapeutic agents for cancer treatment and have shown high complexity in the manner of action and their biological properties.
Janevik-Ivanovska, Emilija   +4 more
core  

Cytotoxicity of 213Bi- and 225Ac-Immunoconjugates

open access: yes, 1996
The paper describes in vitro cytotoxicity experiments with 213-Bi- and 225-Ac-immunoconjugates on the human epidermoid tumour cell line A431 using a blood group A-reactive murine IgG (2D11) as the specific antibody and MOPC 21 as the control antibody ...
DOORNMALEN A.V.   +3 more
core  

In vitro activity of immunoconjugates between cisplatin and an anti-CA125 monoclonal antibody on ovarian cancer cell lines

open access: yes, 1994
Cis-diammine dichloro platinum (II) (CDDP), is a highly potent antineoplastic agent that is used in the treatment of ovarian cancer. However, the clinical use of CDDP is restricted by its severe side effects.
Beck, E.   +5 more
core  

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