Results 81 to 90 of about 8,578 (238)
Hematological Oncology, Volume 43, Issue 4, July 2025.ABSTRACT Relapsed/refractory multiple myeloma (RRMM) patients with dialysis‐dependent renal impairment face limited therapeutic options due to exclusion from clinical trials, a lack of evidence‐based guidelines, and inferior outcomes. Bispecific antibodies targeting B‐cell maturation antigen (BCMA) have shown promise in RRMM treatment but remain ...
Michèle Hoffmann +7 more
wiley +1 more source
Individually Specified Drug Immunoconjugates in Cancer Treatment
The International Journal of Biological Markers, 1989 Forty-three patients with disseminated refractory malignancies each received an individually-specified combination of either Adriamycin (24 patients) or mitomycin-C (19 patients) conjugated murine monoclonal antibodies. Tumors were typed using a panel of
R.K. Oldham +6 more
doaj +1 more source
Deconstructing the Thymic Microenvironment Through Genesis to Senescence
Immunological Reviews, Volume 332, Issue 1, July 2025.ABSTRACT The thymus is essential for adaptive immunity, orchestrating the differentiation of hematopoietic progenitors into various T‐cell lineages. Thymic epithelial cells (TECs) impart this unique function by mediating the major checkpoints in T‐cell differentiation while also imposing stringent tolerance processes required to prevent autoimmunity ...
Michael D'Andrea +2 more
wiley +1 more source
Freeze dried kit formulation of trastuzumab-immunoconjugates
, 2017 Trastuzumab is a humanized anti-HER2 monoclonal antibody used for therapy of metastatic breast cancer. Conjugated antibodies with toxins, drugs and radionuclides, provide high hope for development of cancer-specific cytotoxic reagents. The formulation of
Janevik-Ivanovska, Emilija +3 more
core
From Desferrioxamine B Umpolung to an Enantiopure Bifunctional Chelator for 89Zr‐immunoPET
Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.Functional group transformations were performed at the pendent amine residue of desferrioxamine B (DFO), the commercial siderophore used in various medical applications, including iron decorporation, antibiotic development, and molecular imaging.
Laurie Zujew +2 more
wiley +1 more source
Selection of an Anti-CD20, Single-Chain Antibody by Phage ELISA on Fixed Cells
BioTechniques, 1999 Cloning the correct genes that code for antibody-variable domains from hybridomas is often complicated by the presence of several immunoglobulin transcripts, some of them arising from a myeloma cell line.
Stefanie Schmidt +3 more
doaj +1 more source
Beyond Conventional Approaches: The Revolutionary Role of Nanoparticles in Breast Cancer
MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.This review explores integrated approach of nanotechnology to breast cancer diagnosis and treatment. We highlight imaging techniques for tumor detection and biomarker analysis in biological samples for early diagnosis. Advanced therapies, including targeted drug delivery and antibody‐drug conjugates, enable precise medication transport to cancer cells,
Mohan Liu +7 more
wiley +1 more source
Preparation and in vitro cytotoxic evaluation of taxol immunoconjugates
, 2007 463-468The taxol (paclitaxel) immunoconjugates prepared by derivatizing the taxol at two positions and linking the Mab CIBCNSH3 against EGF receptors were tested for in vitro cytotoxicity.
Ganesh, S +5 more
core
Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Anna Galstyan +20 more
doaj +1 more source
OncoTarget, 2014 In spite of development of molecular therapeutics, multiple myeloma (MM) is fatal in most cases. CD38 is a promising target for selective treatment of MM.
K. Teiluf +15 more
semanticscholar +1 more source