Results 81 to 90 of about 6,305 (206)
Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
Nature Communications, 2019 Brain glioma treatment with checkpoint inhibitor antibodies to cytotoxic T-lymphocyte-associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) was largely unsuccessful due to their inability to cross blood–brain barrier (BBB).
Anna Galstyan +20 more
doaj +1 more source
Toxins, 2019 Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells.
Javier Ruiz-de-la-Herrán +4 more
doaj +1 more source
p-SCN-Bn-DOTA-Trastuzumab immunoconjugates and vibrational spectroscopy examination [PDF]
, 2019 Introduction: Attenuated total reflectance-infrared (ATR-IR) and Raman spectroscopy, as vibrational techniques, provide reliable molecular structure information and are significant for determination of any of changes in the secondary structure.
Janevik-Ivanovska, Emilija +3 more
core +2 more sources
Examinations of the in-vitro-cytotoxicity of 213Bi-immunoconjugates
, 2006 Ziel der Arbeit war die Quantifizierung der Zytotoxizität von Bi-213-Immunkonjugaten in vitro abhängig von der Bindung und Internalisierung an ein tumorzellspezifisches Antigen (delta9-E-Cadherin) mittels klonogenem Test und Analyse von ...
Seidenschwang, Sabine
core
A New Type of Modified Brassinosteroids for Enzyme-linked Immunosorbent Assay
Natural Product Communications, 2008 New modified brassinosteroids (BS) with a full set of specific functional groups and with an additional one at C-26 have been synthesized and used as haptens for enzyme-linked immunosorbent assay. The haptens were conjugated to bovine serum albumin (BSA)
Vladimir Khripach +9 more
doaj +1 more source
, 1996 The anthracycline doxorubicin (DOX) is one of the most effective drugs for the treatment of small-cell lung cancer (SCLC), but its clinical application is limited by unspecific side-effects like cardiotoxicity.
Zangemeister-Wittke, U. +5 more
core +1 more source
Rapid Generation of In Vitro Multicellular Spheroids for the Study of Monoclonal Antibody Therapy
Journal of Cancer, 2011 Tumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates and are difficult to study in vitro. Cells cultured as monolayers typically exhibit less resistance to therapy than those grown in vivo.
Yen T. Phung, Dario Barbone, V. Courtney Broaddus, Mitchell Ho
doaj
International Journal of Nanomedicine, 2021 Zixuan Ye,1,* Yue Zhang,1,* Yuanfen Liu,2,* Yanyan Liu,1 Jiasheng Tu,1 Yan Shen1 1Department of Pharmaceutics, State Key Laboratory of Nature Medicines, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Jiangsu Health ...
Ye Z +5 more
doaj
, 2016 Immunoconjugates of monoclonal antibody BR96 and Doxorubicin have been prepared using a novel series of branched hydrazone linkers. Since each linker bound to the mAb carries two DOX molecules, the DOX/mAb molar ratios of these conjugates were ...
Shirley J. Lasch (2944650) +7 more
core +1 more source
Cytotoxicity of 213Bi- and 225Ac-Immunoconjugates
, 1996 The paper describes in vitro cytotoxicity experiments with 213-Bi- and 225-Ac-immunoconjugates on the human epidermoid tumour cell line A431 using a blood group A-reactive murine IgG (2D11) as the specific antibody and MOPC 21 as the control antibody ...
DOORNMALEN A.V. +3 more
core +1 more source