Results 61 to 70 of about 8,578 (238)

Affibody-beta-galactosidase immunoconjugates produced as soluble fusion proteins in the Escherichia coli cytosol

, 2003
Recombinant immunoconjugates constitute a novel class of immunoassay reagents produced by genetic fusion between an antigen recognizing moiety and a reporter enzyme or fluorescent protein, obviating the need for chemical coupling.
Wester, K., Ponten, F., Nygren, Per-Åke,, Ronnmark, J., Uhlen, M., Kampf, C., Asplund, A., Hoiden-Guthenberg, I.   +7 more
core   +1 more source

Impaired FADD/BID signaling mediates cross-resistance to immunotherapy in Multiple Myeloma

Communications Biology, 2023
The treatment landscape in multiple myeloma (MM) is shifting from genotoxic drugs to immunotherapies. Monoclonal antibodies, immunoconjugates, T-cell engaging antibodies and CART cells have been incorporated into routine treatment algorithms, resulting ...
Umair Munawar, Xiang Zhou, Sabrina Prommersberger, Silvia Nerreter, Cornelia Vogt, Maximilian J. Steinhardt, Marietta Truger, Julia Mersi, Eva Teufel, Seungbin Han, Larissa Haertle, Nicole Banholzer, Patrick Eiring, Sophia Danhof, Miguel Angel Navarro-Aguadero, Adrian Fernandez-Martin, Alejandra Ortiz-Ruiz, Santiago Barrio, Miguel Gallardo, Antonio Valeri, Eva Castellano, Peter Raab, Maximilian Rudert, Claudia Haferlach, Markus Sauer, Michael Hudecek, J. Martinez-Lopez, Johannes Waldschmidt, Hermann Einsele, Leo Rasche, K. Martin Kortüm   +30 more
doaj   +1 more source

A Multiepitope‐Based Lateral Flow Assay for Leprosy Antibodies

Analysis &Sensing, Volume 6, Issue 2, March 2026.
An innovative lateral flow assay for leprosy diagnosis is based on gold nanoparticles and synthetic Mycobacterium leprae epitopes conjugated to keyhole limpet hemocyanin protein to enhance antibody detection. This strategy provides a rapid, accurate, and low‐cost approach for resource‐limited settings, enabling the early detection of infection. Leprosy
Cristiane Zocatelli‐Ribeiro, Camila dos Anjos Proença, Ana Carolina da Rosa Nogarolli, Ana Fabiele Domakoski Trevisan, Thiago Neves Machado, João Carlos Degraf Muzzi, Larissa Magalhães Alvarenga, Juliana de Moura   +7 more
wiley   +1 more source

Site-specific modification of ED-B-targeting antibody using intein-fusion technology

BMC Biotechnology, 2011
Background A promising new approach in cancer therapy is the use of tumor specific antibodies coupled to cytotoxic agents. Currently these immunoconjugates are prepared by rather unspecific coupling chemistries, resulting in heterogeneous products.
Greven Simone, Bringmann Peter, Möhlmann Sina, Harrenga Axel   +3 more
doaj   +1 more source

The Squalene Oil‐in‐Water Nanoemulsion Vaccine Carrier AddaVax Potentiates TLR‐Induced B‐Cell Responses

Cytometry Part A, Volume 109, Issue 3, Page 180-191, March 2026.
ABSTRACT For vaccination, the mechanisms of action of antigens and of immunostimulatory pathogen‐associated molecular pattern (PAMP) adjuvants are better understood than the roles of the depot, carrier, and other formulation‐related influences. Here, we carried out cytometric studies of vaccine formulations and the effect of adjuvant formulations on B ...
Egest J. Pone, Jiin Felgner, Jenny Hernandez‐Davies, D. Huw Davies   +3 more
wiley   +1 more source

Society for Maternal‐Fetal Medicine Consult Series #76: Cancer in pregnancy

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Approximately one in 1000 pregnancies is complicated by the diagnosis of cancer each year, and the incidence of cancer among reproductive‐age individuals is increasing. Management of a pregnant person with cancer can be complex and warrants a multidisciplinary approach to care.
Society for Maternal‐Fetal Medicine (SMFM), Moti Gulersen, Clarissa Bonanno, Justin S. Brandt, Stephanie Pierce, Elyce H. Cardonick, SMFM Publications Committee   +6 more
wiley   +1 more source

Paving the Way for Reliable Alzheimer's Disease Blood Diagnosis by Quadruple Electrochemical Immunosensing

ChemElectroChem, 2022
Alzheimer's disease (AD), the most common neurodegenerative disorder, demands new cost‐effective and easy‐to‐use strategies for its reliable detection, mainly in the preclinical stages.
Alejandro Valverde, José M. Gordón Pidal, Ana Montero‐Calle, Beatriz Arévalo, Dr. Verónica Serafín, Dr. Miguel Calero, Dr. María Moreno‐Guzmán, Dr. Miguel Ángel López, Prof. Alberto Escarpa, Prof. Paloma Yáñez‐Sedeño, Dr. Rodrigo Barderas, Dr. Susana Campuzano, Prof. José M. Pingarrón   +12 more
doaj   +1 more source

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source

Antibody-Drug Conjugates as a Potential a Systemic Treatment Strategy for Brain Metastases in Cases of Solid Tumors

Journal of Oncological Sciences
Large molecular antibody-drug conjugates (ADCs) are able to easily access the site of metastasis in the brain due to the edematous structure of brain metastases, facilitating considerably high concentrations of the cytotoxic component of these ADCs in ...
Didem DİVRİKLİOĞLU, İsmail BAYRAKÇI, Erkan ÖZCAN, İrfan ÇİÇİN   +3 more
doaj   +1 more source

SYNTHESIS OF 25-HYDROXYVITAMIN D3 CONJUGATE WITH KEYHOLE LIMPET HEMOCYANIN AND OBTAINING OF IMMUNE SERA [PDF]

Biotechnologia Acta, 2015
The study was aimed at obtaining polyclonal antibodies that recognize 25-Hydroxyvitamin D3, for their further specifications and applications in immunochemical test systems of 25-Hydroxyvitamin D3, determination in blood serum.
А. O. Mazanova, I. O. Shymanskyy, D. M. Petukhov, L. B. Drobot, M. M. Veliky, S. V. Komisarenko   +5 more
doaj   +1 more source