Results 61 to 70 of about 5,209 (179)

Selection of an Anti-CD20, Single-Chain Antibody by Phage ELISA on Fixed Cells

BioTechniques, 1999
Cloning the correct genes that code for antibody-variable domains from hybridomas is often complicated by the presence of several immunoglobulin transcripts, some of them arising from a myeloma cell line.
Stefanie Schmidt, Michael Braunagel, Timo Kürschner, Melvyn Little   +3 more
doaj   +1 more source

Elranatamab for Relapsed/Refractory Multiple Myeloma With Severe Renal Impairment Requiring Hemodialysis

Hematological Oncology, Volume 43, Issue 4, July 2025.
ABSTRACT Relapsed/refractory multiple myeloma (RRMM) patients with dialysis‐dependent renal impairment face limited therapeutic options due to exclusion from clinical trials, a lack of evidence‐based guidelines, and inferior outcomes. Bispecific antibodies targeting B‐cell maturation antigen (BCMA) have shown promise in RRMM treatment but remain ...
Michèle Hoffmann, Barbara Jeker, Uyen Huynh‐Do, Yara Banz, Jeanne Godau, Elisabeth Weber, Ulrike Bacher, Thomas Pabst   +7 more
wiley   +1 more source

Author Correction: Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Anna Galstyan, Janet L. Markman, Ekaterina S. Shatalova, Antonella Chiechi, Alan J. Korman, Rameshwar Patil, Dmytro Klymyshyn, Warren G. Tourtellotte, Liron L. Israel, Oliver Braubach, Vladimir A. Ljubimov, Leila A. Mashouf, Arshia Ramesh, Zachary B. Grodzinski, Manuel L. Penichet, Keith L. Black, Eggehard Holler, Tao Sun, Hui Ding, Alexander V. Ljubimov, Julia Y. Ljubimova   +20 more
doaj   +1 more source

CD74 in kidney disease

Frontiers in Immunology, 2015
CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT/MIF-2).
Lara eValiño-Rivas, Ciro eBaeza-Bermejillo, Laura eGonzalez-Lafuente, Ana eSanz, Alberto eOrtiz, Alberto eOrtiz, Alberto eOrtiz, Maria D Sanchez-Niño   +7 more
doaj   +1 more source

Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

Nature Communications, 2019
Brain glioma treatment with checkpoint inhibitor antibodies to cytotoxic T-lymphocyte-associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) was largely unsuccessful due to their inability to cross blood–brain barrier (BBB).
Anna Galstyan, Janet L. Markman, Ekaterina S. Shatalova, Antonella Chiechi, Alan J. Korman, Rameshwar Patil, Dmytro Klymyshyn, Warren G. Tourtellotte, Liron L. Israel, Oliver Braubach, Vladimir A. Ljubimov, Leila A. Mashouf, Arshia Ramesh, Zachary B. Grodzinski, Manuel L. Penichet, Keith L. Black, Eggehard Holler, Tao Sun, Hui Ding, Alexander V. Ljubimov, Julia Y. Ljubimova   +20 more
doaj   +1 more source

Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins

Toxins, 2019
Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells.
Javier Ruiz-de-la-Herrán, Jaime Tomé-Amat, Rodrigo Lázaro-Gorines, José G. Gavilanes, Javier Lacadena   +4 more
doaj   +1 more source

A New Type of Modified Brassinosteroids for Enzyme-linked Immunosorbent Assay

Natural Product Communications, 2008
New modified brassinosteroids (BS) with a full set of specific functional groups and with an additional one at C-26 have been synthesized and used as haptens for enzyme-linked immunosorbent assay. The haptens were conjugated to bovine serum albumin (BSA)
Vladimir Khripach, Vladimir Zhabinskii, Alexey Antonchick, Raissa Litvinovskaya, Svetlana Drach, Oleg Sviridov, Andrey Pryadko, Tatyana Novik, Vitaliy Matveentsev, Bernd Schneider   +9 more
doaj   +1 more source

Rapid Generation of In Vitro Multicellular Spheroids for the Study of Monoclonal Antibody Therapy

Journal of Cancer, 2011
Tumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates and are difficult to study in vitro. Cells cultured as monolayers typically exhibit less resistance to therapy than those grown in vivo.
Yen T. Phung, Dario Barbone, V. Courtney Broaddus, Mitchell Ho
doaj  

EGFR Targeted Cetuximab-Valine-Citrulline (vc)-Doxorubicin Immunoconjugates- Loaded Bovine Serum Albumin (BSA) Nanoparticles for Colorectal Tumor Therapy

International Journal of Nanomedicine, 2021
Zixuan Ye,1,* Yue Zhang,1,* Yuanfen Liu,2,* Yanyan Liu,1 Jiasheng Tu,1 Yan Shen1 1Department of Pharmaceutics, State Key Laboratory of Nature Medicines, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Jiangsu Health ...
Ye Z, Zhang Y, Liu Y, Liu Y, Tu J, Shen Y   +5 more
doaj  

Immunoconjugates in cervical cancer: a bibliometric and thematic mapping analysis of global research trends, 2015-2024. [PDF]

Front Oncol
Wang X, Xiong D, Cui S, Duan B, Ding G, Huang Y, Wang Q.   +6 more
europepmc   +1 more source