Results 51 to 60 of about 8,578 (238)

Treatment strategies for cisplatin-ineligible metastatic bladder cancer: Emerging therapies and future perspectives [PDF]

Investigative and Clinical Urology
Recently, the combination of enfortumab vedotin and pembrolizumab has been recommended as the preferred first-line therapy for metastatic or locally advanced urothelial carcinoma owing to its substantial survival benefits.
Kyung Hwan Kim, Do Thanh Truc Phan, Hong Koo Ha, Eui Hyun Jung, Geehyun Song, Ho Kyung Seo   +5 more
doaj   +1 more source

Cytotoxicity of Selenium Immunoconjugates against Triple Negative Breast Cancer Cells

International Journal of Molecular Sciences, 2018
Within the subtypes of breast cancer, those identified as triple negative for expression of estrogen receptor α (ESR1), progesterone receptor (PR) and human epidermal growth factor 2 (HER2), account for 10–20% of breast cancers, yet result in 30% of ...
Soni Khandelwal, M. Boylan, J. Spallholz, L. Gollahon   +3 more
semanticscholar   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

HER1-targeted 86Y-panitumumab possesses superior targeting characteristics than 86Y-cetuximab for PET imaging of human malignant mesothelioma tumors xenografts. [PDF]

PLoS ONE, 2011
Malignant mesothelioma (MM), a rare form of cancer is often associated with previous exposure to fibrous minerals, such as asbestos. Asbestos exposure increases HER1-activity and expression in pre-clinical models.
Tapan K Nayak, Kayhan Garmestani, Diane E Milenic, Kwamena E Baidoo, Martin W Brechbiel   +4 more
doaj   +1 more source

The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. [PDF]

PLoS ONE, 2011
Tumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates. Tumor microenvironments, however, are difficult to study in vitro. Cells cultured as monolayers exhibit less resistance to therapy than those grown in
Xinran Xiang, Yen Phung, Mingqian Feng, Kunio Nagashima, Jingli Zhang, V Courtney Broaddus, Raffit Hassan, David Fitzgerald, Mitchell Ho   +8 more
doaj   +1 more source

“Click-to-Clear”: A Strategy to Minimize Radioactivity from the Blood Pool Utilizing Staudinger Ligation

Pharmaceutics, 2023
The availability of several bioorthogonal reactions that can proceed selectively and efficiently under physiologically relevant conditions has garnered the interest of biochemists and organic chemists alike. Bioorthogonal cleavage reactions represent the
Nisarg Soni, Swarbhanu Sarkar, Abhinav Bhise, Yeong Su Ha, Wonchoul Park, A-Ram Yu, Virendra Kumar, Jeong Eun Lim, Young-Ran Yoon, Jeongsoo Yoo   +9 more
doaj   +1 more source

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

Defining the tumor microenvironment of non‐small cell lung cancer

Immunology &Cell Biology, Volume 104, Issue 5, Page 499-518, May‐June 2026.
The tumor microenvironment (TME) in non‐small cell lung cancer is highly heterogeneous, both at a patient level and tumor microenvironment resolution. Defining the tumor microenvironment from patient‐responders and non‐responders will aid in the development of targeted therapeutics specific for each individual patient.
Kidane Siele Embaye, Tony Blick, Vahid Yaghoubi Naei, Ken O'Byrne, Brett G. M. Hughes, Arutha Kulasinghe   +5 more
wiley   +1 more source

Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components

Toxins, 2011
Immunotoxins and antibody-drug conjugates are protein-based drugs combining a target-specific binding domain with a cytotoxic domain. Such compounds are potentially therapeutic against diseases including cancer, and several clinical trials have shown ...
Luigi Cattel, Paola Brusa, Franco Dosio
doaj   +1 more source

Melatonin Counteracts Mechanical Unloading‐Induced Bone Loss Through YTHDF3‐Mediated m6A Modification of Dapk2 mRNA

Journal of Pineal Research, Volume 78, Issue 3, May 2026.
ABSTRACT Disuse osteoporosis, a consequence of prolonged mechanical unloading, is characterized by bone loss and elevated fracture susceptibility. Although melatonin exhibits bone‑anabolic properties, its mechanistic role in the context of mechanical unloading remains elusive.
Quan Sun, Liqun Xu, Zhikui Li, Junfei Zhang, Xiran Zhao, Lijun Zhang, Xiaoyan Zhang, Jiangdong Zhao, Yingjun Tan, Luyao Wang, Ge Zhang, Zebing Hu, Shu Zhang, Fei Shi   +13 more
wiley   +1 more source