Results 51 to 60 of about 6,305 (206)

Melatonin Counteracts Mechanical Unloading‐Induced Bone Loss Through YTHDF3‐Mediated m6A Modification of Dapk2 mRNA

Journal of Pineal Research, Volume 78, Issue 3, May 2026.
ABSTRACT Disuse osteoporosis, a consequence of prolonged mechanical unloading, is characterized by bone loss and elevated fracture susceptibility. Although melatonin exhibits bone‑anabolic properties, its mechanistic role in the context of mechanical unloading remains elusive.
Quan Sun, Liqun Xu, Zhikui Li, Junfei Zhang, Xiran Zhao, Lijun Zhang, Xiaoyan Zhang, Jiangdong Zhao, Yingjun Tan, Luyao Wang, Ge Zhang, Zebing Hu, Shu Zhang, Fei Shi   +13 more
wiley   +1 more source

A Multiepitope‐Based Lateral Flow Assay for Leprosy Antibodies

Analysis &Sensing, Volume 6, Issue 2, March 2026.
An innovative lateral flow assay for leprosy diagnosis is based on gold nanoparticles and synthetic Mycobacterium leprae epitopes conjugated to keyhole limpet hemocyanin protein to enhance antibody detection. This strategy provides a rapid, accurate, and low‐cost approach for resource‐limited settings, enabling the early detection of infection. Leprosy
Cristiane Zocatelli‐Ribeiro, Camila dos Anjos Proença, Ana Carolina da Rosa Nogarolli, Ana Fabiele Domakoski Trevisan, Thiago Neves Machado, João Carlos Degraf Muzzi, Larissa Magalhães Alvarenga, Juliana de Moura   +7 more
wiley   +1 more source

Antibody-Drug Conjugates as a Potential a Systemic Treatment Strategy for Brain Metastases in Cases of Solid Tumors

Journal of Oncological Sciences
Large molecular antibody-drug conjugates (ADCs) are able to easily access the site of metastasis in the brain due to the edematous structure of brain metastases, facilitating considerably high concentrations of the cytotoxic component of these ADCs in ...
Didem DİVRİKLİOĞLU, İsmail BAYRAKÇI, Erkan ÖZCAN, İrfan ÇİÇİN   +3 more
doaj   +1 more source

SYNTHESIS OF 25-HYDROXYVITAMIN D3 CONJUGATE WITH KEYHOLE LIMPET HEMOCYANIN AND OBTAINING OF IMMUNE SERA [PDF]

Biotechnologia Acta, 2015
The study was aimed at obtaining polyclonal antibodies that recognize 25-Hydroxyvitamin D3, for their further specifications and applications in immunochemical test systems of 25-Hydroxyvitamin D3, determination in blood serum.
А. O. Mazanova, I. O. Shymanskyy, D. M. Petukhov, L. B. Drobot, M. M. Veliky, S. V. Komisarenko   +5 more
doaj   +1 more source

The Squalene Oil‐in‐Water Nanoemulsion Vaccine Carrier AddaVax Potentiates TLR‐Induced B‐Cell Responses

Cytometry Part A, Volume 109, Issue 3, Page 180-191, March 2026.
ABSTRACT For vaccination, the mechanisms of action of antigens and of immunostimulatory pathogen‐associated molecular pattern (PAMP) adjuvants are better understood than the roles of the depot, carrier, and other formulation‐related influences. Here, we carried out cytometric studies of vaccine formulations and the effect of adjuvant formulations on B ...
Egest J. Pone, Jiin Felgner, Jenny Hernandez‐Davies, D. Huw Davies   +3 more
wiley   +1 more source

Affibody-beta-galactosidase immunoconjugates produced as soluble fusion proteins in the Escherichia coli cytosol

, 2003
Recombinant immunoconjugates constitute a novel class of immunoassay reagents produced by genetic fusion between an antigen recognizing moiety and a reporter enzyme or fluorescent protein, obviating the need for chemical coupling.
Wester, K., Ponten, F., Nygren, Per-Åke,, Ronnmark, J., Uhlen, M., Kampf, C., Asplund, A., Hoiden-Guthenberg, I.   +7 more
core   +1 more source

Evaluation of non-radioactive lutetium- and yttrium-labeled immunoconjugates of rituximab - a vibrational spectroscopy study [PDF]

, 2015
Fourier Transform Infrared (FT-IR) and Raman Spectroscopy were used to study the molecular structure of the recombinant monoclonal antibody and anti-CD20-conjugates which are intended to be used as anti-cancer therapeutic agents.
Janevik-Ivanovska, Emilija, Gjorgieva Ackova, Darinka, Smilkov, Katarina, Stafilov, Trajče, Arsova-Sarafinovska, Zorica, Makreski, Petre   +5 more
core   +2 more sources

Society for Maternal‐Fetal Medicine Consult Series #76: Cancer in pregnancy

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Approximately one in 1000 pregnancies is complicated by the diagnosis of cancer each year, and the incidence of cancer among reproductive‐age individuals is increasing. Management of a pregnant person with cancer can be complex and warrants a multidisciplinary approach to care.
Society for Maternal‐Fetal Medicine (SMFM), Moti Gulersen, Clarissa Bonanno, Justin S. Brandt, Stephanie Pierce, Elyce H. Cardonick, SMFM Publications Committee   +6 more
wiley   +1 more source

Synthesis and biological evaluation of novel drug-monoclonal anti-carcinoembryonic antigen antibody immunoconjugates

, 1994
The objective of this project was to produce novel drug-monoclonal antibody immunoconjugates for site specific drug delivery. The model in these studies consisted of a target, the tumor associated carcinoembryonic antigen (CEA) expressed by a wide range ...
Lau, Achilles K. M.
core   +1 more source

Identifying Distinct Molecular Subtypes and Establishing a Prognostic Framework for DLBCL Patients via Multiomics Analysis and Machine Learning Approaches

Human Mutation, Volume 2026, Issue 1, 2026.
Diffuse large B‐cell lymphoma (DLBCL) is characterized by profound heterogeneity that underpins varied clinical outcomes. To decipher this complexity, we performed an integrated single‐cell and genomic analysis. Using scRNA‐seq data (GSE182434), we identified six distinct malignant B‐cell subclusters (MB1‐MB6) within the DLBCL ecosystem.
Hongyu Shen, Jinbo Lu, Qi Yan, Jinjiang Chou, Xiao Liang, Weifei Fan, Lei Fan, Miklos Sahin -Toth   +7 more
wiley   +1 more source