Results 31 to 40 of about 6,305 (206)

Design and Simple Assembly of Gold Nanostar Bioconjugates for Surface-Enhanced Raman Spectroscopy Immunoassays

Nanomaterials, 2019
Immunoassays using Surface-Enhanced Raman Spectroscopy are especially interesting on account not only of their increased sensitivity, but also due to its easy translation to point-of-care formats.
Maria João Oliveira, Miguel P. de Almeida, Daniela Nunes, Elvira Fortunato, Rodrigo Martins, Eulália Pereira, Hugh J. Byrne, Hugo Águas, Ricardo Franco   +8 more
doaj   +1 more source

Advancements in non-small cell lung cancer treatment: from early to advanced stages

Oncology in Clinical Practice
Over the past years, tremendous progress has been made in the treatment available for non-small cell lung cancer patients (NSCLC), both in the early and advanced stages of the disease.
Adam Płużański, Aleksandra Piórek
doaj   +1 more source

Treatment strategies for cisplatin-ineligible metastatic bladder cancer: Emerging therapies and future perspectives [PDF]

Investigative and Clinical Urology
Recently, the combination of enfortumab vedotin and pembrolizumab has been recommended as the preferred first-line therapy for metastatic or locally advanced urothelial carcinoma owing to its substantial survival benefits.
Kyung Hwan Kim, Do Thanh Truc Phan, Hong Koo Ha, Eui Hyun Jung, Geehyun Song, Ho Kyung Seo   +5 more
doaj   +1 more source

Alpha-particle emitting 213Bi-anti-EGFR immunoconjugates eradicate tumor cells independent of oxygenation. [PDF]

PLoS ONE, 2013
Hypoxia is a central problem in tumor treatment because hypoxic cells are less sensitive to chemo- and radiotherapy than normoxic cells. Radioresistance of hypoxic tumor cells is due to reduced sensitivity towards low Linear Energy Transfer (LET ...
Christian Wulbrand, Christof Seidl, Florian C Gaertner, Frank Bruchertseifer, Alfred Morgenstern, Markus Essler, Reingard Senekowitsch-Schmidtke   +6 more
doaj   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

Synthesis and biodistribution of immunoconjugates of a human IgM and polymeric drug carriers [PDF]

, 1992
The synthesis and purification of radiolabelled immunoconjugates, composed of a human IgM monoclonal antibody directed against an intracellular tumour-associated antigen and either poly (alpha-L-glutamic acid) (PGA) or poly[N5-(2-hydroxyethyl)-L ...
Feijen, J., Loeffen, P., Hoes, C.J.T., Bos, E.S., Kaspersen, F., Grootoonk, J., Boon, P.J., Winters, M., Anderson, James M., Schlachter, I.   +9 more
core   +2 more sources

HER1-targeted 86Y-panitumumab possesses superior targeting characteristics than 86Y-cetuximab for PET imaging of human malignant mesothelioma tumors xenografts. [PDF]

PLoS ONE, 2011
Malignant mesothelioma (MM), a rare form of cancer is often associated with previous exposure to fibrous minerals, such as asbestos. Asbestos exposure increases HER1-activity and expression in pre-clinical models.
Tapan K Nayak, Kayhan Garmestani, Diane E Milenic, Kwamena E Baidoo, Martin W Brechbiel   +4 more
doaj   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. [PDF]

PLoS ONE, 2011
Tumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates. Tumor microenvironments, however, are difficult to study in vitro. Cells cultured as monolayers exhibit less resistance to therapy than those grown in
Xinran Xiang, Yen Phung, Mingqian Feng, Kunio Nagashima, Jingli Zhang, V Courtney Broaddus, Raffit Hassan, David Fitzgerald, Mitchell Ho   +8 more
doaj   +1 more source

“Click-to-Clear”: A Strategy to Minimize Radioactivity from the Blood Pool Utilizing Staudinger Ligation

Pharmaceutics, 2023
The availability of several bioorthogonal reactions that can proceed selectively and efficiently under physiologically relevant conditions has garnered the interest of biochemists and organic chemists alike. Bioorthogonal cleavage reactions represent the
Nisarg Soni, Swarbhanu Sarkar, Abhinav Bhise, Yeong Su Ha, Wonchoul Park, A-Ram Yu, Virendra Kumar, Jeong Eun Lim, Young-Ran Yoon, Jeongsoo Yoo   +9 more
doaj   +1 more source