Results 31 to 40 of about 5,209 (179)
HER1-targeted 86Y-panitumumab possesses superior targeting characteristics than 86Y-cetuximab for PET imaging of human malignant mesothelioma tumors xenografts. [PDF]
PLoS ONE, 2011 Malignant mesothelioma (MM), a rare form of cancer is often associated with previous exposure to fibrous minerals, such as asbestos. Asbestos exposure increases HER1-activity and expression in pre-clinical models.
Tapan K Nayak +4 more
doaj +1 more source
VIEW, EarlyView.Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf +5 more
wiley +1 more source
The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. [PDF]
PLoS ONE, 2011 Tumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates. Tumor microenvironments, however, are difficult to study in vitro. Cells cultured as monolayers exhibit less resistance to therapy than those grown in
Xinran Xiang +8 more
doaj +1 more source
Pharmaceutics, 2023 The availability of several bioorthogonal reactions that can proceed selectively and efficiently under physiologically relevant conditions has garnered the interest of biochemists and organic chemists alike. Bioorthogonal cleavage reactions represent the
Nisarg Soni +9 more
doaj +1 more source
Advanced Materials Technologies, Volume 11, Issue 13, 8 July 2026.This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane +4 more
wiley +1 more source
Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components
Toxins, 2011 Immunotoxins and antibody-drug conjugates are protein-based drugs combining a target-specific binding domain with a cytotoxic domain. Such compounds are potentially therapeutic against diseases including cancer, and several clinical trials have shown ...
Luigi Cattel, Paola Brusa, Franco Dosio
doaj +1 more source
Nanobodies: A Promising Toolkit for Diagnostic Applications
SmartMat, Volume 7, Issue 3, June 2026.This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu +11 more
wiley +1 more source
Impaired FADD/BID signaling mediates cross-resistance to immunotherapy in Multiple Myeloma
Communications Biology, 2023 The treatment landscape in multiple myeloma (MM) is shifting from genotoxic drugs to immunotherapies. Monoclonal antibodies, immunoconjugates, T-cell engaging antibodies and CART cells have been incorporated into routine treatment algorithms, resulting ...
Umair Munawar +30 more
doaj +1 more source
Defining the tumor microenvironment of non‐small cell lung cancer
Immunology &Cell Biology, Volume 104, Issue 5, Page 499-518, May‐June 2026.The tumor microenvironment (TME) in non‐small cell lung cancer is highly heterogeneous, both at a patient level and tumor microenvironment resolution. Defining the tumor microenvironment from patient‐responders and non‐responders will aid in the development of targeted therapeutics specific for each individual patient.
Kidane Siele Embaye +5 more
wiley +1 more source
Site-specific modification of ED-B-targeting antibody using intein-fusion technology
BMC Biotechnology, 2011 Background A promising new approach in cancer therapy is the use of tumor specific antibodies coupled to cytotoxic agents. Currently these immunoconjugates are prepared by rather unspecific coupling chemistries, resulting in heterogeneous products.
Greven Simone +3 more
doaj +1 more source