FHR4‐based immunoconjugates direct complement‐dependent cytotoxicity and phagocytosis towards HER2‐positive cancer cells [PDF]
Molecular Oncology, 2019 Directing selective complement activation towards tumour cells is an attractive strategy to promote their elimination. In the present work, we have generated heteromultimeric immunoconjugates that selectively activate the complement alternative pathway ...
Carole Seguin‐Devaux +8 more
doaj +2 more sources
Decoding the Factor H-Related Proteins: Gatekeepers of Complement Dysregulation in AMD. [PDF]
Eur J ImmunolThis review will explore the role of the factor H‐related (FHR) proteins in age‐related macular degeneration (AMD), their accumulation in the outer blood/retinal barrier, and how they may contribute to barrier dysfunction and inflammation. ABSTRACT Age‐related macular degeneration (AMD) is the third most common form of blindness in the Western world ...
Tang J, Zgoda N, Clark SJ.
europepmc +2 more sources
Analytical approaches for assessing immunoconjugates integrity and characterization prior to radiolabeling [PDF]
, 2023 Immunoconjugates, which have highly specific targeting towards certain antigens, are molecules that are built from three parts: an antibody, a therapeutic payload, and a linker between them.
Janevik-Ivanovska, Emilija +2 more
core +2 more sources
Development of radiopharmaceuticals for targeted alpha therapy: Where do we stand?
Frontiers in Medicine, 2022 Targeted alpha therapy is an oncological treatment, where cytotoxic doses of alpha radiation are locally delivered to tumor cells, while the surrounding healthy tissue is minimally affected.
Roger M. Pallares +2 more
doaj +1 more source
Comparison of HER2-Targeted Antibodies for Fluorescence-Guided Surgery in Breast Cancer
Molecular Imaging, 2021 Background. Although therapeutic advances have led to enhanced survival in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, detection of residual disease remains challenging.
Solmaz AghaAmiri +8 more
doaj +1 more source
Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages. [PDF]
PLoS ONE, 2011 Sialoadhesin is exclusively expressed on specific subpopulations of macrophages. Since sialoadhesin-positive macrophages are involved in inflammatory autoimmune diseases, such as multiple sclerosis, and potentially in the generation of immune responses ...
Peter L Delputte +9 more
doaj +1 more source
Preparation and characterization of immunoconjugates as an initial step for targeted alpha therapy [PDF]
, 2023 The basic principle of targeted alpha therapy (TAT) is that the alpha-emitting radionuclide is attached to specifically designed biomolecules, formulated as conjugates from antibodies, peptides and other small molecules. The design and characterization
Gaschet, Joëlle +5 more
core +2 more sources
Freeze dried kit formulation of trastuzumab-immunoconjugates [PDF]
, 2017 Trastuzumab is a humanized anti-HER2 monoclonal antibody used for therapy of metastatic breast cancer. Conjugated antibodies with toxins, drugs and radionuclides, provide high hope for development of cancer-specific cytotoxic reagents. The formulation of
Janevik-Ivanovska, Emilija +3 more
core +2 more sources
Site-Specifically Labeled Immunoconjugates for Molecular Imaging—Part 1: Cysteine Residues and Glycans [PDF]
, 2016 Due to their remarkable selectivity and specificity for cancer biomarkers, immunoconjugates have emerged as extremely promising vectors for the delivery of diagnostic radioisotopes and fluorophores to malignant tissues.
Adumeau, Pierre +7 more
core +3 more sources
Management of HER2-Low Metastatic Breast Cancer: A Comprehensive Statement by an Expert Group from the Middle East and Africa Region [PDF]
Middle East Journal of CancerApproximately 50 to 67% of breast cancers (BCs), traditionally categorized as human epidermal growth factor receptor 2 (HER2)-negative, but demonstrating low HER2 expression, are now being defined as a new HER2-low subset or HER2-low category of BC.
Shaheenah Dawood +9 more
doaj +1 more source