Decoding the Factor H-Related Proteins: Gatekeepers of Complement Dysregulation in AMD. [PDF]
Eur J ImmunolThis review will explore the role of the factor H‐related (FHR) proteins in age‐related macular degeneration (AMD), their accumulation in the outer blood/retinal barrier, and how they may contribute to barrier dysfunction and inflammation. ABSTRACT Age‐related macular degeneration (AMD) is the third most common form of blindness in the Western world ...
Tang J, Zgoda N, Clark SJ.
europepmc +2 more sources
Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages. [PDF]
PLoS ONE, 2011 Sialoadhesin is exclusively expressed on specific subpopulations of macrophages. Since sialoadhesin-positive macrophages are involved in inflammatory autoimmune diseases, such as multiple sclerosis, and potentially in the generation of immune responses ...
Peter L Delputte +9 more
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Emerging Advances in Nanomedicine for Targeted Cancer Photoimmunotherapy and Photo-Immunometabolic Therapy. [PDF]
Wiley Interdiscip Rev Nanomed NanobiotechnolSchematic representation of nanoparticle‐mediated photothermal therapy (PTT) inducing anti‐tumor immune responses. Nanoparticles are administered to a tumor‐bearing mouse and accumulate at the tumor site. Upon laser irradiation, the nanoparticles generate reactive oxygen species (ROS) within cancer cells, leading to cellular apoptosis.
Chota A +3 more
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Frontiers in Pharmacology, 2022 Immune checkpoint mechanisms are important molecular cell systems that maintain tolerance toward autoantigens in order to prevent immunity-mediated accidental damage.
Andrea Zanello +4 more
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Management of HER2-Low Metastatic Breast Cancer: A Comprehensive Statement by an Expert Group from the Middle East and Africa Region [PDF]
Middle East Journal of CancerApproximately 50 to 67% of breast cancers (BCs), traditionally categorized as human epidermal growth factor receptor 2 (HER2)-negative, but demonstrating low HER2 expression, are now being defined as a new HER2-low subset or HER2-low category of BC.
Shaheenah Dawood +9 more
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Antibody-Drug Conjugates: Functional Principles and Applications in Oncology and Beyond
Vaccines, 2021 In the era of precision medicine, antibody-based therapeutics are rapidly enriched with emerging advances and new proof-of-concept formats. In this context, antibody-drug conjugates (ADCs) have evolved to merge the high selectivity and specificity of ...
Charalampos Theocharopoulos +4 more
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Antibody-drug conjugates in treating older patients suffering from cancer: what is the real value?
Human Vaccines & Immunotherapeutics, 2021 Immunotherapeutic drugs and target therapies have represented an epochal change in treating cancer patients. They represent an attractive option in oncologists’ armamentarium, particularly if we consider the optimal balance between efficacy and toxicity.
Gianluca Perego +3 more
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Electrochemical Immunosensing of ST2: A Checkpoint Target in Cancer Diseases
Biosensors, 2021 A magnetic beads (MB)-involved amperometric immunosensor for the determination of ST2, a member of the IL1 receptor family, is reported in this work.
Rebeca M. Torrente-Rodríguez +8 more
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Molecular Oncology, 2019 Directing selective complement activation towards tumour cells is an attractive strategy to promote their elimination. In the present work, we have generated heteromultimeric immunoconjugates that selectively activate the complement alternative pathway ...
Carole Seguin‐Devaux +8 more
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DOTA-functionalized polylysine: a high number of DOTA chelates positively influences the biodistribution of enzymatic conjugated anti-tumor antibody chCE7agl. [PDF]
PLoS ONE, 2013 Site-specific enzymatic reactions with microbial transglutaminase (mTGase) lead to a homogenous species of immunoconjugates with a defined ligand/antibody ratio.
Jürgen Grünberg +6 more
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