Results 11 to 20 of about 8,578 (238)

Alpha-particle emitting 213Bi-anti-EGFR immunoconjugates eradicate tumor cells independent of oxygenation. [PDF]

PLoS ONE, 2013
Hypoxia is a central problem in tumor treatment because hypoxic cells are less sensitive to chemo- and radiotherapy than normoxic cells. Radioresistance of hypoxic tumor cells is due to reduced sensitivity towards low Linear Energy Transfer (LET ...
Christian Wulbrand, Christof Seidl, Florian C Gaertner, Frank Bruchertseifer, Alfred Morgenstern, Markus Essler, Reingard Senekowitsch-Schmidtke   +6 more
doaj   +6 more sources

Soluble CD4 and low molecular weight CD4-mimetic compounds sensitize cells to be killed by anti-HIV cytotoxic immunoconjugates

Journal of Virology, 2023
The reservoir of HIV-infected cells that persist in the face of effective anti-retroviral therapy (ART) is the barrier to curing HIV infection. These long-lived CD4+ cells carry a functional provirus that can become activated upon immune stimulation ...
Seth H. Pincus, Megan Stackhouse, Connie Watt, Kelli Ober, Frances M. Cole, Hung-Ching Chen, Amos B. Smith III, Tami R. Peters   +7 more
semanticscholar   +2 more sources

Site-Specifically Labeled Immunoconjugates for Molecular Imaging—Part 1: Cysteine Residues and Glycans [PDF]

Molecular Imaging and Biology, 2016
Due to their remarkable selectivity and specificity for cancer biomarkers, immunoconjugates have emerged as extremely promising vectors for the delivery of diagnostic radioisotopes and fluorophores to malignant tissues.
Pierre Adumeau, Sai Kiran Sharma, Colleen Brent, Brian M. Zeglis   +3 more
semanticscholar   +2 more sources

Site-Specific, Platform-Based Conjugation Strategy for the Synthesis of Dual-Labeled Immunoconjugates for Bimodal PET/NIRF Imaging of HER2-Positive Tumors.

Bioconjugate chemistry, 2022
Because positron emission tomography (PET) and optical imaging are very complementary, the combination of these two imaging modalities is very enticing in the oncology field.
Pierre Adumeau, R. Raavé, Milou Boswinkel, S. Heskamp, H. Wessels, A. V. van Gool, M. Moreau, C. Bernhard, Laurène Da Costa, V. Goncalves, F. Denat   +10 more
semanticscholar   +2 more sources

EGFR Targeted Cetuximab-Valine-Citrulline (vc)-Doxorubicin Immunoconjugates- Loaded Bovine Serum Albumin (BSA) Nanoparticles for Colorectal Tumor Therapy

International Journal of Nanomedicine, 2021
Zixuan Ye,1,* Yue Zhang,1,* Yuanfen Liu,2,* Yanyan Liu,1 Jiasheng Tu,1 Yan Shen1 1Department of Pharmaceutics, State Key Laboratory of Nature Medicines, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Jiangsu Health ...
Ye Z, Zhang Y, Liu Y, Liu Y, Tu J, Shen Y   +5 more
doaj   +2 more sources

Emerging Advances in Nanomedicine for Targeted Cancer Photoimmunotherapy and Photo-Immunometabolic Therapy. [PDF]

Wiley Interdiscip Rev Nanomed Nanobiotechnol
Schematic representation of nanoparticle‐mediated photothermal therapy (PTT) inducing anti‐tumor immune responses. Nanoparticles are administered to a tumor‐bearing mouse and accumulate at the tumor site. Upon laser irradiation, the nanoparticles generate reactive oxygen species (ROS) within cancer cells, leading to cellular apoptosis.
Chota A, Sarbadhikary P, Abrahamse H, George BP.   +3 more
europepmc   +2 more sources

Therapeutic Antibody-Like Immunoconjugates against Tissue Factor with the Potential to Treat Angiogenesis-Dependent as Well as Macrophage-Associated Human Diseases

Antibodies, 2018
Accumulating evidence suggests that tissue factor (TF) is selectively expressed in pathological angiogenesis-dependent as well as macrophage-associated human diseases.
Zhiwei Hu
doaj   +2 more sources

Immunoconjugates in the management of hairy cell leukemia [PDF]

Best Practice & Research Clinical Haematology, 2015
Hairy cell leukemia (HCL) is an indolent B-cell malignancy effectively treated but not often cured by purine analog therapy; after multiple courses of purine analogs, patients can become purine analog resistant and in need of alternative therapies ...
R. Kreitman, I. Pastan
semanticscholar   +3 more sources

Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin

ACS Omega, 2018
Fentanyl and its derivatives have become pervasive contaminants in the U.S. heroin supply. Previously, we reported a proof-of-concept vaccine designed to combat against heroin contaminated with fentanyl.
Candy S. Hwang, Lauren C. Smith, Yoshihiro Natori, Beverly Ellis, Bin Zhou, Kim D. Janda   +5 more
doaj   +2 more sources

Characterization of the increased cytotoxicity of gelonin anti-T cell immunoconjugates compared with ricin A chain immunoconjugates [PDF]

Clinical and Experimental Immunology, 1994
SUMMARYRibosomal inactivating proteins such as gelonin (Gel) and ricin A chain (RTA) conjugated to MoAbs bind to specific target cells, and upon internalization inhibit protein synthesis, ultimately resulting in cell death. We report here that Gel anti-T cell MoAb conjugates are more cytotoxic than RTA conjugates when tested against human peripheral ...
D M, Fishwild, H M, Wu, S F, Carroll, S L, Bernhard   +3 more
openaire   +3 more sources