Results 21 to 30 of about 5,209 (179)

Evaluation of immunoconjugates of non-radioactive lutetium- and yttrium-rituximab – a vibrational spectroscopy study

Macedonian Journal of Chemistry and Chemical Engineering, 2015
Fourier Transform Infrared (FT-IR) and Raman spectroscopy were used to study the molecular structure of the recombinant monoclonal antibody and anti-CD20-conjugates which are intended to be used as anti-cancer therapeutic agents.
Darinka Gjorgieva Ackova, Katarina Smilkov, Emilija Janevik-Ivanovska, Trajče Stafilov, Zorica Arsova-Sarafinovska, Petre Makreski   +5 more
doaj   +1 more source

Humanization, Radiolabeling and Biodistribution Studies of an IgG₁-Type Antibody Targeting Uncomplexed PSA for Theranostic Applications

Pharmaceuticals, 2021
Metastatic castration-resistant prostate cancer is today incurable. Conventional imaging methods have limited detection, affecting their ability to give an accurate outcome prognosis, and current therapies for metastatic prostate cancer are insufficient.
Joanna Strand, Kjell Sjöström, Urpo J. Lamminmaki, Oskar Vilhelmsson Timmermand, Sven-Erik Strand, Thuy A. Tran   +5 more
doaj   +1 more source

Cytotoxicity Effect of Quinoin, Type 1 Ribosome-Inactivating Protein from Quinoa Seeds, on Glioblastoma Cells

Toxins, 2021
Ribosome-inactivating proteins (RIPs) are found in several edible plants and are well characterized. Many studies highlight their use in cancer therapy, alone or as immunoconjugates, linked to monoclonal antibodies directed against target cancer cells ...
Rossella Rotondo, Sara Ragucci, Salvatore Castaldo, Maria Antonietta Oliva, Nicola Landi, Paolo V. Pedone, Antonietta Arcella, Antimo Di Maro   +7 more
doaj   +1 more source

Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy

Toxins, 2011
Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death.
Andrea Bolognesi, Massimo Bortolotti, Manuela Pedrazzi, Letizia Polito   +3 more
doaj   +1 more source

UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer

Molecules, 2020
Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells.
Evgenii L. Guryev, Anita S. Smyshlyaeva, Natalia Y. Shilyagina, Evgeniya A. Sokolova, Samah Shanwar, Alexey B. Kostyuk, Alexander V. Lyubeshkin, Alexey A. Schulga, Elena V. Konovalova, Quan Lin, Indrajit Roy, Irina V. Balalaeva, Sergey M. Deyev, Andrei V. Zvyagin   +13 more
doaj   +1 more source

Design and Simple Assembly of Gold Nanostar Bioconjugates for Surface-Enhanced Raman Spectroscopy Immunoassays

Nanomaterials, 2019
Immunoassays using Surface-Enhanced Raman Spectroscopy are especially interesting on account not only of their increased sensitivity, but also due to its easy translation to point-of-care formats.
Maria João Oliveira, Miguel P. de Almeida, Daniela Nunes, Elvira Fortunato, Rodrigo Martins, Eulália Pereira, Hugh J. Byrne, Hugo Águas, Ricardo Franco   +8 more
doaj   +1 more source

Advancements in non-small cell lung cancer treatment: from early to advanced stages

Oncology in Clinical Practice
Over the past years, tremendous progress has been made in the treatment available for non-small cell lung cancer patients (NSCLC), both in the early and advanced stages of the disease.
Adam Płużański, Aleksandra Piórek
doaj   +1 more source

Treatment strategies for cisplatin-ineligible metastatic bladder cancer: Emerging therapies and future perspectives [PDF]

Investigative and Clinical Urology
Recently, the combination of enfortumab vedotin and pembrolizumab has been recommended as the preferred first-line therapy for metastatic or locally advanced urothelial carcinoma owing to its substantial survival benefits.
Kyung Hwan Kim, Do Thanh Truc Phan, Hong Koo Ha, Eui Hyun Jung, Geehyun Song, Ho Kyung Seo   +5 more
doaj   +1 more source

Alpha-particle emitting 213Bi-anti-EGFR immunoconjugates eradicate tumor cells independent of oxygenation. [PDF]

PLoS ONE, 2013
Hypoxia is a central problem in tumor treatment because hypoxic cells are less sensitive to chemo- and radiotherapy than normoxic cells. Radioresistance of hypoxic tumor cells is due to reduced sensitivity towards low Linear Energy Transfer (LET ...
Christian Wulbrand, Christof Seidl, Florian C Gaertner, Frank Bruchertseifer, Alfred Morgenstern, Markus Essler, Reingard Senekowitsch-Schmidtke   +6 more
doaj   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source