Results 21 to 30 of about 6,305 (206)
Antibody-Drug Conjugates: Functional Principles and Applications in Oncology and Beyond
Vaccines, 2021 In the era of precision medicine, antibody-based therapeutics are rapidly enriched with emerging advances and new proof-of-concept formats. In this context, antibody-drug conjugates (ADCs) have evolved to merge the high selectivity and specificity of ...
Charalampos Theocharopoulos +4 more
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Antibody-drug conjugates in treating older patients suffering from cancer: what is the real value?
Human Vaccines & Immunotherapeutics, 2021 Immunotherapeutic drugs and target therapies have represented an epochal change in treating cancer patients. They represent an attractive option in oncologists’ armamentarium, particularly if we consider the optimal balance between efficacy and toxicity.
Gianluca Perego +3 more
doaj +1 more source
Electrochemical Immunosensing of ST2: A Checkpoint Target in Cancer Diseases
Biosensors, 2021 A magnetic beads (MB)-involved amperometric immunosensor for the determination of ST2, a member of the IL1 receptor family, is reported in this work.
Rebeca M. Torrente-Rodríguez +8 more
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Emerging Advances in Nanomedicine for Targeted Cancer Photoimmunotherapy and Photo-Immunometabolic Therapy. [PDF]
Wiley Interdiscip Rev Nanomed NanobiotechnolSchematic representation of nanoparticle‐mediated photothermal therapy (PTT) inducing anti‐tumor immune responses. Nanoparticles are administered to a tumor‐bearing mouse and accumulate at the tumor site. Upon laser irradiation, the nanoparticles generate reactive oxygen species (ROS) within cancer cells, leading to cellular apoptosis.
Chota A +3 more
europepmc +2 more sources
DOTA-functionalized polylysine: a high number of DOTA chelates positively influences the biodistribution of enzymatic conjugated anti-tumor antibody chCE7agl. [PDF]
PLoS ONE, 2013 Site-specific enzymatic reactions with microbial transglutaminase (mTGase) lead to a homogenous species of immunoconjugates with a defined ligand/antibody ratio.
Jürgen Grünberg +6 more
doaj +1 more source
Macedonian Journal of Chemistry and Chemical Engineering, 2015 Fourier Transform Infrared (FT-IR) and Raman spectroscopy were used to study the molecular structure of the recombinant monoclonal antibody and anti-CD20-conjugates which are intended to be used as anti-cancer therapeutic agents.
Darinka Gjorgieva Ackova +5 more
doaj +1 more source
Pharmaceuticals, 2021 Metastatic castration-resistant prostate cancer is today incurable. Conventional imaging methods have limited detection, affecting their ability to give an accurate outcome prognosis, and current therapies for metastatic prostate cancer are insufficient.
Joanna Strand +5 more
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Toxins, 2021 Ribosome-inactivating proteins (RIPs) are found in several edible plants and are well characterized. Many studies highlight their use in cancer therapy, alone or as immunoconjugates, linked to monoclonal antibodies directed against target cancer cells ...
Rossella Rotondo +7 more
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Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy
Toxins, 2011 Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death.
Andrea Bolognesi +3 more
doaj +1 more source
UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer
Molecules, 2020 Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells.
Evgenii L. Guryev +13 more
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