Results 41 to 50 of about 6,305 (206)

Dynamic Single‐Binding Event Profiling With on‐Chip Microlenses for Wash‐Free Digital Biosensing

Advanced Science, Volume 13, Issue 46, 17 August 2026.
A microlens‐enhanced platform enables real‐time tracking and digital counting of single‐binding events using conventional bright‐field microscopy. Amplified scattering signals from gold nanoparticle labels and kinetic signature analysis allow wash‐free discrimination between specific and nonspecific interactions, while providing kinetic and mechanistic
Tingting Zhan, Lianyu Lu, Guoqiang Gu, Pengcheng Zhang, Jienan Shen, Xiaotian Tan, Wei Ye, Shi Hu, Yi Zhang, Hao Yu, Shaoqin Liu, Hairong Zheng, Hui Yang   +12 more
wiley   +1 more source

Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components

Toxins, 2011
Immunotoxins and antibody-drug conjugates are protein-based drugs combining a target-specific binding domain with a cytotoxic domain. Such compounds are potentially therapeutic against diseases including cancer, and several clinical trials have shown ...
Luigi Cattel, Paola Brusa, Franco Dosio
doaj   +1 more source

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, Volume 11, Issue 13, 8 July 2026.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source

Synthesis and biological evaluation of immunoconjugates of adriamycin and a human IgM linked by poly[N5-(2-hydroxyethyl)-l-glutamine [PDF]

, 1996
The synthesis and purification of radiolabelled immunoconjugates, composed of a human IgM monoclonal antibody (IgM 16.88) directed against an intracellular tumour-associated antigen, the drug carrier poly[N5-(2-hydroxyethyl)--glutamine] (PHEG) and the ...
Feijen, J., Hoes, C.J.T., E.S. Bos, Kaspersen, F., E. van der Struik, Grootoonk, J., Schlachter, I., van Doornmalen, A., M. Ankoné, J. Feijen, van der Struik, E., I. Schlachter, Pham, D., de Man, A., Boon, P.J., van Ettekoven, A., F. Kaspersen, P.J. Boon, A. de Man, Bos, E.S., D. Pham, C.J.T. Hoes, Ankoné, M., A. van Doornmalen, A. van Ettekoven, J. Grootoonk   +25 more
core   +2 more sources

Impaired FADD/BID signaling mediates cross-resistance to immunotherapy in Multiple Myeloma

Communications Biology, 2023
The treatment landscape in multiple myeloma (MM) is shifting from genotoxic drugs to immunotherapies. Monoclonal antibodies, immunoconjugates, T-cell engaging antibodies and CART cells have been incorporated into routine treatment algorithms, resulting ...
Umair Munawar, Xiang Zhou, Sabrina Prommersberger, Silvia Nerreter, Cornelia Vogt, Maximilian J. Steinhardt, Marietta Truger, Julia Mersi, Eva Teufel, Seungbin Han, Larissa Haertle, Nicole Banholzer, Patrick Eiring, Sophia Danhof, Miguel Angel Navarro-Aguadero, Adrian Fernandez-Martin, Alejandra Ortiz-Ruiz, Santiago Barrio, Miguel Gallardo, Antonio Valeri, Eva Castellano, Peter Raab, Maximilian Rudert, Claudia Haferlach, Markus Sauer, Michael Hudecek, J. Martinez-Lopez, Johannes Waldschmidt, Hermann Einsele, Leo Rasche, K. Martin Kortüm   +30 more
doaj   +1 more source

Site-specific modification of ED-B-targeting antibody using intein-fusion technology

BMC Biotechnology, 2011
Background A promising new approach in cancer therapy is the use of tumor specific antibodies coupled to cytotoxic agents. Currently these immunoconjugates are prepared by rather unspecific coupling chemistries, resulting in heterogeneous products.
Greven Simone, Bringmann Peter, Möhlmann Sina, Harrenga Axel   +3 more
doaj   +1 more source

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

Defining the tumor microenvironment of non‐small cell lung cancer

Immunology &Cell Biology, Volume 104, Issue 5, Page 499-518, May‐June 2026.
The tumor microenvironment (TME) in non‐small cell lung cancer is highly heterogeneous, both at a patient level and tumor microenvironment resolution. Defining the tumor microenvironment from patient‐responders and non‐responders will aid in the development of targeted therapeutics specific for each individual patient.
Kidane Siele Embaye, Tony Blick, Vahid Yaghoubi Naei, Ken O'Byrne, Brett G. M. Hughes, Arutha Kulasinghe   +5 more
wiley   +1 more source

Cell Internalization Studies of Gadofullerene-(ZME-018) Immunoconjugates into A375m Melanoma Cells [PDF]

, 2011
Fullerene (C60)-monoclonal antibody (mAb) immunoconjugates have been determined to internalize into target cells using water-soluble Gd3+ ion-filled metallofullerenes (Gd@C60[OH]x). Two separate conjugations of Gd@C60(OH)x with the antibody ZME-018 and a
Wilson, Lon J., Marks, John W., Bolskar, Robert D., Berger, Christopher Scott, Rosenblum, Michael G.   +4 more
core   +1 more source

Paving the Way for Reliable Alzheimer's Disease Blood Diagnosis by Quadruple Electrochemical Immunosensing

ChemElectroChem, 2022
Alzheimer's disease (AD), the most common neurodegenerative disorder, demands new cost‐effective and easy‐to‐use strategies for its reliable detection, mainly in the preclinical stages.
Alejandro Valverde, José M. Gordón Pidal, Ana Montero‐Calle, Beatriz Arévalo, Dr. Verónica Serafín, Dr. Miguel Calero, Dr. María Moreno‐Guzmán, Dr. Miguel Ángel López, Prof. Alberto Escarpa, Prof. Paloma Yáñez‐Sedeño, Dr. Rodrigo Barderas, Dr. Susana Campuzano, Prof. José M. Pingarrón   +12 more
doaj   +1 more source