Results 41 to 50 of about 5,209 (179)

Melatonin Counteracts Mechanical Unloading‐Induced Bone Loss Through YTHDF3‐Mediated m6A Modification of Dapk2 mRNA

Journal of Pineal Research, Volume 78, Issue 3, May 2026.
ABSTRACT Disuse osteoporosis, a consequence of prolonged mechanical unloading, is characterized by bone loss and elevated fracture susceptibility. Although melatonin exhibits bone‑anabolic properties, its mechanistic role in the context of mechanical unloading remains elusive.
Quan Sun, Liqun Xu, Zhikui Li, Junfei Zhang, Xiran Zhao, Lijun Zhang, Xiaoyan Zhang, Jiangdong Zhao, Yingjun Tan, Luyao Wang, Ge Zhang, Zebing Hu, Shu Zhang, Fei Shi   +13 more
wiley   +1 more source

A Multiepitope‐Based Lateral Flow Assay for Leprosy Antibodies

Analysis &Sensing, Volume 6, Issue 2, March 2026.
An innovative lateral flow assay for leprosy diagnosis is based on gold nanoparticles and synthetic Mycobacterium leprae epitopes conjugated to keyhole limpet hemocyanin protein to enhance antibody detection. This strategy provides a rapid, accurate, and low‐cost approach for resource‐limited settings, enabling the early detection of infection. Leprosy
Cristiane Zocatelli‐Ribeiro, Camila dos Anjos Proença, Ana Carolina da Rosa Nogarolli, Ana Fabiele Domakoski Trevisan, Thiago Neves Machado, João Carlos Degraf Muzzi, Larissa Magalhães Alvarenga, Juliana de Moura   +7 more
wiley   +1 more source

Paving the Way for Reliable Alzheimer's Disease Blood Diagnosis by Quadruple Electrochemical Immunosensing

ChemElectroChem, 2022
Alzheimer's disease (AD), the most common neurodegenerative disorder, demands new cost‐effective and easy‐to‐use strategies for its reliable detection, mainly in the preclinical stages.
Alejandro Valverde, José M. Gordón Pidal, Ana Montero‐Calle, Beatriz Arévalo, Dr. Verónica Serafín, Dr. Miguel Calero, Dr. María Moreno‐Guzmán, Dr. Miguel Ángel López, Prof. Alberto Escarpa, Prof. Paloma Yáñez‐Sedeño, Dr. Rodrigo Barderas, Dr. Susana Campuzano, Prof. José M. Pingarrón   +12 more
doaj   +1 more source

The Squalene Oil‐in‐Water Nanoemulsion Vaccine Carrier AddaVax Potentiates TLR‐Induced B‐Cell Responses

Cytometry Part A, Volume 109, Issue 3, Page 180-191, March 2026.
ABSTRACT For vaccination, the mechanisms of action of antigens and of immunostimulatory pathogen‐associated molecular pattern (PAMP) adjuvants are better understood than the roles of the depot, carrier, and other formulation‐related influences. Here, we carried out cytometric studies of vaccine formulations and the effect of adjuvant formulations on B ...
Egest J. Pone, Jiin Felgner, Jenny Hernandez‐Davies, D. Huw Davies   +3 more
wiley   +1 more source

Society for Maternal‐Fetal Medicine Consult Series #76: Cancer in pregnancy

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Approximately one in 1000 pregnancies is complicated by the diagnosis of cancer each year, and the incidence of cancer among reproductive‐age individuals is increasing. Management of a pregnant person with cancer can be complex and warrants a multidisciplinary approach to care.
Society for Maternal‐Fetal Medicine (SMFM), Moti Gulersen, Clarissa Bonanno, Justin S. Brandt, Stephanie Pierce, Elyce H. Cardonick, SMFM Publications Committee   +6 more
wiley   +1 more source

Antibody-Drug Conjugates as a Potential a Systemic Treatment Strategy for Brain Metastases in Cases of Solid Tumors

Journal of Oncological Sciences
Large molecular antibody-drug conjugates (ADCs) are able to easily access the site of metastasis in the brain due to the edematous structure of brain metastases, facilitating considerably high concentrations of the cytotoxic component of these ADCs in ...
Didem DİVRİKLİOĞLU, İsmail BAYRAKÇI, Erkan ÖZCAN, İrfan ÇİÇİN   +3 more
doaj   +1 more source

SYNTHESIS OF 25-HYDROXYVITAMIN D3 CONJUGATE WITH KEYHOLE LIMPET HEMOCYANIN AND OBTAINING OF IMMUNE SERA [PDF]

Biotechnologia Acta, 2015
The study was aimed at obtaining polyclonal antibodies that recognize 25-Hydroxyvitamin D3, for their further specifications and applications in immunochemical test systems of 25-Hydroxyvitamin D3, determination in blood serum.
А. O. Mazanova, I. O. Shymanskyy, D. M. Petukhov, L. B. Drobot, M. M. Veliky, S. V. Komisarenko   +5 more
doaj   +1 more source

Identifying Distinct Molecular Subtypes and Establishing a Prognostic Framework for DLBCL Patients via Multiomics Analysis and Machine Learning Approaches

Human Mutation, Volume 2026, Issue 1, 2026.
Diffuse large B‐cell lymphoma (DLBCL) is characterized by profound heterogeneity that underpins varied clinical outcomes. To decipher this complexity, we performed an integrated single‐cell and genomic analysis. Using scRNA‐seq data (GSE182434), we identified six distinct malignant B‐cell subclusters (MB1‐MB6) within the DLBCL ecosystem.
Hongyu Shen, Jinbo Lu, Qi Yan, Jinjiang Chou, Xiao Liang, Weifei Fan, Lei Fan, Miklos Sahin -Toth   +7 more
wiley   +1 more source

An Overview of Emerging Trends in Targeted Therapy of Triple‐Negative Breast Cancer

International Journal of Breast Cancer, Volume 2026, Issue 1, 2026.
Triple‐negative breast cancer (TNBC) is a biologically diverse, highly aggressive class of breast cancer defined by the absence of estrogen, progesterone, and HER2 receptors. It accounts for approximately 10%–20% of all invasive breast cancers, and disproportionately affects women of younger ages and from minority groups.
Anuj Kumar, Suresh Subramanian, V. Ganesh   +2 more
wiley   +1 more source

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source