Results 91 to 100 of about 6,305 (206)

Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata

, 1997
The present paper describes two immunoconjugates consisting of an anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb), named Mint5, covalently linked to the type 1 ribosome-inactivating proteins (RIPs) ocymoidine (Ocy) and pyramidatine
Di Loreto M., Di Massimo A. M., Polito L., Mele A., De Santis R., Pacilli A., Bolognesi A., Raucci G., D'Alatri L., Stirpe F.   +9 more
core   +1 more source

Enzymatic Cleavage of Peptide-Linked Radiolabels from Immunoconjugates

, 2016
We have incorporated peptides selected by combinatorial library [Peterson, J. J., and Meares, C. F. (1998) Bioconjugate Chem. 9, 618−626) into peptide-linked radiolabeled immunoconjugates of the form DOTA-peptide-antibody. Decapeptide linkers -GFQGVQFAGF-
Claude F. Meares (2083129), James J. Peterson (751252)   +1 more
core   +1 more source

Synthesis and Evaluation of Astatinated N‑[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates

, 2016
Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50–100 μm) of α particles, making the method suitable for treatment of disseminated occult ...
Holger Jensen (738329), Sture Lindegren (738320), Stig Palm (738328), Per Albertsson (613832), Sofia Svedhem (736928), Tom Bäck (1403161), Anna Gustafsson (257681), Emma Aneheim (738327)   +7 more
core   +1 more source

ase T1 based immunoconjugates: the role of intracellular trafficking in cytotoxic efficiency

, 2015
Toxins have been thoroughly studied for their use as therapeutic agents in search of an improvement in toxic efficiency together with a minimization of their undesired side effects.
Javier Lacadena, Álvaro Martínez‐del‐Pozo, Jaime Tomé‐Amat, Tomé-Amat, Jaime, Martínez Del Pozo, Álvaro, Javier Ruiz‐de‐la‐Herrán, Lacadena García-Gallo, Francisco Javier, José G. Gavilanes, Gavilanes, José G., Ruiz de la Herrán, Javier   +9 more
core   +1 more source

Development of Novel Immunoconjugates Activating NK Cells for Targeted Immunotherapy [PDF]

Background: NK cells are crucial effectors in the immune response against viral diseases and cancer. Specifically in HIV-1 and pancreatic ductal adenocarcinoma (PDAC), their functions are suppressed leading to impaired cytotoxicity towards the target. To
ROLIN, Camille Amélie
core  

Physico-chemical assessment of labeled freeze dried kits of trastuzumab-immunoconjugates significant for breast cancer therapy [PDF]

, 2018
Introduction: Monoclonal antibodies appears as an important therapeutic agents for cancer treatment and have shown high complexity in the manner of action and their biological properties.
Janevik-Ivanovska, Emilija, Ruskovska, Tatjana, Dzodic, Predrag, Arev, Marija, Makreski, Petre   +4 more
core  

In vitro activity of immunoconjugates between cisplatin and an anti-CA125 monoclonal antibody on ovarian cancer cell lines

, 1994
Cis-diammine dichloro platinum (II) (CDDP), is a highly potent antineoplastic agent that is used in the treatment of ovarian cancer. However, the clinical use of CDDP is restricted by its severe side effects.
Beck, E., Lang, N., Wildt, L., Hofmann, M., Bernhardt, Günther, Jäger, W.   +5 more
core  

Microscale Native Size Exclusion Chromatography High Resolution Mass Spectrometry for the Determination of the Chelator-To-Antibody Ratio of Immunoconjugates

Raw SEC-MS data of the following immunoconjugates: trastuzumab-N-suc-DFO, trastuzumab-mal-DFO, trastuzumab-TMTHSI-DFO, trastuzumab-NCS-DFO and ipilimumab-N-suc-DFO. Also included here are the tested buffer concentrations (200–1000 mM ammonium acetate) of
Supramolecular Separations (HIMS, FNWI), Gargano, Andrea, van der Zon, Annika   +2 more
core   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody-Based Imaging and Therapy. [PDF]

Adv Sci (Weinh)
Vivier D, Kple MG, Ariztia J, Leroux M, Moreau M, Claron M, Cheveau M, Laouafa A, Kownacka A, Petitot C, Simonet J, Dias AMM, Poty S, Truillet C, Collin B, Oudot A, Denat F.   +16 more
europepmc   +1 more source

Immunoconjugate [PDF]

, 2020
openaire   +1 more source