Results 91 to 100 of about 8,578 (238)
, 2016 Immunoconjugates of monoclonal antibody BR96 and Doxorubicin have been prepared using a novel series of branched hydrazone linkers. Since each linker bound to the mAb carries two DOX molecules, the DOX/mAb molar ratios of these conjugates were ...
Shirley J. Lasch (2944650) +7 more
core +1 more source
, 1994 The objective of this project was to produce novel drug-monoclonal antibody immunoconjugates for site specific drug delivery. The model in these studies consisted of a target, the tumor associated carcinoembryonic antigen (CEA) expressed by a wide range ...
Lau, Achilles K. M.
core
, 1997 The present paper describes two immunoconjugates consisting of an anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb), named Mint5, covalently linked to the type 1 ribosome-inactivating proteins (RIPs) ocymoidine (Ocy) and pyramidatine
Di Loreto M. +9 more
core +1 more source
Frontiers in Immunology, 2015 CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT/MIF-2).
Lara eValiño-Rivas +7 more
doaj +1 more source
Immunoconjugates: Lessons from animal models
Annals of Oncology, 1994 Monoclonal antibody-mediated cancer therapy has evolved through a challenging chain of problems and solutions. The very limited therapeutic success obtained with unarmed monoclonal antibodies has increased the interest in different antibody-based targeting strategies, and numerous preclinical and even clinical studies with immunoconjugates have now ...
S, Canevari +2 more
openaire +2 more sources
Preparation and examination of 177Lu- and 90Y-labeled immunoconjugates of Trastuzumab [PDF]
, 2019 Trastuzumab is a monoclonal antibody for treatment of HER2 positive breast cancer. Labelled antibody with lutetium-177 and yttrium-90 has been investigated as potential radiopharmaceutical agent for use in radioimmunotherapy.
Janevik-Ivanovska, Emilija +7 more
core
, 2016 Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50–100 μm) of α particles, making the method suitable for treatment of disseminated occult ...
Holger Jensen (738329) +7 more
core +1 more source
Enzymatic Cleavage of Peptide-Linked Radiolabels from Immunoconjugates
, 2016 We have incorporated peptides selected by combinatorial library [Peterson, J. J., and Meares, C. F. (1998) Bioconjugate Chem. 9, 618−626) into peptide-linked radiolabeled immunoconjugates of the form DOTA-peptide-antibody. Decapeptide linkers -GFQGVQFAGF-
Claude F. Meares (2083129) +1 more
core +1 more source
Examinations of the in-vitro-cytotoxicity of 213Bi-immunoconjugates
, 2006 Ziel der Arbeit war die Quantifizierung der Zytotoxizität von Bi-213-Immunkonjugaten in vitro abhängig von der Bindung und Internalisierung an ein tumorzellspezifisches Antigen (delta9-E-Cadherin) mittels klonogenem Test und Analyse von ...
Seidenschwang, Sabine
core
Toxins, 2019 Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells.
Javier Ruiz-de-la-Herrán +4 more
doaj +1 more source