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Radioimmunotherapy with Alpha-Particle-Emitting Immunoconjugates
Science, 1988Alpha particles are energetic short-range ions whose higher linear energy transfer produces extreme cytotoxicity. An α-particle-emitting radioimmunoconjugate consisting of a bismuth-212-labeled monoclonal immunoglobulin M specific for the murine T cell/neuroectodermal surface antigen Thy 1.2 was prepared.
R M, Macklis +8 more
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Intraperitoneal immunoconjugates.
Cancer research, 1990Intracavitary instillation of radioantibodies has been proposed as therapy for anatomically confined malignant disease. To evaluate this therapeutic strategy, a monoclonal antibody reactive with human transferrin receptor (7D3) was evaluated for localization in a human malignant mesothelioma transplanted i.p. in athymic nude mice.
T W, Griffin +7 more
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Immunoconjugate Anticancer Therapeutics
2009Immunoconjugate therapy has entered the mainstream of cancer management with the regulatory approval and the bench to bedside transition of three antibody conjugates for lymphoma and leukemia. A number of antibody conjugates of radionuclides, drugs, and protein toxins are in various stages of clinical development.
Serengulam V. Govindan +1 more
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Targeted Drug Delivery Using Immunoconjugates
Journal of Immunotherapy, 2011Antibody-drug conjugates (also known as "immunoconjugates") have only recently entered the arsenal of anticancer drugs, but the number of undergoing clinical trials including them is ever increasing and most therapeutic antibodies are now patented including their potential immunoconjugate derivatives.
PASQUETTO, MARIA VALENTINA +4 more
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Immunoconjugates: Current Status and Future Potential
Journal of Drug Targeting, 2002Whilst the concepts involved in immunoconjugates go back two centuries to the ideas of Ehrlich; it was only in the early 1980s that biotechnology gave us the tools to make pure immunoconjugates, in quantities sufficient for clinical studies [Garnett, M.C. (2002) "Targeted drug conjugates: principles and progress".
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Potential Use of Immunoconjugates for AIDS Therapy
AIDS Research and Human Retroviruses, 1992More than a dozen of hybrid proteins possessing reactivity with human immunodeficiency virus-type 1-(HIV-1) infected cells and cytotoxicity have been produced and studied by several groups. These proteins are prepared either by chemical cross-linking of a toxin and a carrier molecule or by expressing fused genes of the two moieties.
Y W, Kim, T W, Chang
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Stabilisation of immunoconjugates by trehalose
Biotechnology Letters, 2000Stable immunoconjugates were prepared in the presence of 400 mM trehalose. Their residual activity after freeze-drying, rehydration and incubation for 9 h at 40 °C was 35%. Freeze-dried conjugates containing 400 mM trehalose incubated at 40 °C for 4 days retained 80% of their original activity.
Maria Izabel Esteves +5 more
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Immunoconjugates of Carbon Nanostructures
2006For the first time, carbon nanostructures have been designed and synthesized to form immunoconjugates with monoclonal antibodies (mAb) for use in cell-targeted cancer diagnosis and therapy. The immunoconjugates are derived from various nanoscale carbon-based building blocks, specifically fullerenes (C60 ), gadofullerenes (M C60) and ultra-short carbon ...
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Tumour-targeted chemotherapy with immunoconjugates of calicheamicin
Expert Opinion on Biological Therapy, 2004Antibody-targeted chemotherapy is a therapeutic strategy in cancer therapy that involves a monoclonal antibody specific for a tumour-associated antigen, covalently linked via a suitable linker to a potent cytotoxic agent. Tumour-targeted delivery of a cytotoxic agent in the form of an immunoconjugate is expected to improve its antitumour activity and ...
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