Results 181 to 190 of about 130,186 (296)

Preanalytical variables affect predictive immunohistochemical biomarker testing in non–small cell lung carcinoma cytology specimens

open access: yesCancer Cytopathology, Volume 134, Issue 11, November 2026.
Abstract Background Several therapeutic targets for non–small cell lung carcinoma (NSCLC) rely on protein expression by immunohistochemistry (IHC). Most biomarkers are validated on formalin‐fixed, paraffin‐embedded (FFPE) tissue; however, cytologic specimens, including cell blocks (CBs), that are subject to preanalytical variables are increasingly used.
Saroja Devi Geetha   +3 more
wiley   +1 more source

Breast cancer-associated fibroblast-derived exosomal miR-1290 promotes triple-negative breast cancer cell proliferation. [PDF]

open access: yesSignal Transduct Target Ther
Lee J   +18 more
europepmc   +1 more source

Cell Blocks and the Milan System for Reporting Salivary Gland Cytopathology: A Meta‐Analysis

open access: yesDiagnostic Cytopathology, Volume 54, Issue 11, Page 829-836, November 2026.
ABSTRACT Background The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is a classification system first released in 2018. It provides a standardized categorization for salivary gland lesions. Cell blocks can be prepared from fine‐needle aspirations (FNAs) and can be utilized for the diagnostics of salivary gland lesions.
Aada Närhi   +3 more
wiley   +1 more source

Pathogenic Variants in HEPACAM Alter Protein Localization and Interactome in Astrocytes of the Developing Mouse Cortex

open access: yesGlia, Volume 74, Issue 11, November 2026.
Pathogenic variants alter hepaCAM protein distribution. Astrocyte‐specific hepaCAM TurboID reveals KCNQ2 as a new interaction partner. Pathogenic variants alter hepaCAM association with key transmembrane proteins. ABSTRACT Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy characterized by early‐onset macrocephaly,
Robert W. Lewis   +10 more
wiley   +1 more source

Cell Surface Markers Identify Astrocyte Subpopulations in the Adult Hippocampus With a Heterogeneous Response to Aging

open access: yesGlia, Volume 74, Issue 11, November 2026.
ATP1B2 and GLAST identify two astrocyte subpopulations in the hippocampus with distinct molecular signatures. Transcriptomic shifts during aging differ between both subpopulations. Aged ATP1B2+ astrocytes rewire their metabolism while double‐positive aged astrocytes display a reduced synaptogenic capability.
Lucía Casares‐Crespo   +6 more
wiley   +1 more source

FGF13 Alleviates the Aging Process in Mice by Regulating Astrocyte Function in the Medial Prefrontal Cortex via Phafin2 Signaling Pathway

open access: yesAging Cell, Volume 25, Issue 11, November 2026.
FGF13 is significantly downregulated in the aging brain, particularly in cortical astrocytes within the medial prefrontal cortex. Genetic knockdown of FGF13 in astrocytes accelerates aging phenotypes and impairs neurological function in mice, while its overexpression effectively delays cognitive decline.
Rui Zheng   +9 more
wiley   +1 more source

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