Results 201 to 210 of about 120,698 (291)

Polarized effects of adenosine on blood–brain barrier integrity: Tightening from the luminal and opening from the abluminal side

British Journal of Pharmacology, Volume 183, Issue 16, Page 4761-4777, August 2026.
Background and Purpose Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach The expression of adenosine receptors was measured by qRT‐PCR.
András Harazin, Gabriela Hurtado‐Alvarado, Lilla Barna, Arturo Contis‐Montes de Oca, Rocío Ruíz‐Manzano, Krisztián Laczi, András Kincses, Gergő Porkoláb, Gang Chen, Beatriz Gómez‐González, Mária A. Deli   +10 more
wiley   +1 more source

Cytochemical Characterization for Macrophages Engulf Cholesterol Crystals and Myeloperoxidase in Neutrophil Extracellular Traps (NETs) Sampled From Disrupted Aortic Plaques. [PDF]

J Histochem Cytochem
Iwa N, Noda H, Yutani C, Komatsu S, Takahashi S, Takewa M, Ohara T, Kodama K.   +7 more
europepmc   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Multiplex Cryoimmunostaining in Fine-Needle Aspiration Biopsies and Effusion Samples: Preliminary Results.

Acta Cytol
Miceska S, Kholová I, Kloboves Prevodnik V.   +2 more
europepmc   +1 more source

Evaluating the peripheral nervous system pathology of Alzheimer's disease utilizing a functional human NMJ microphysiological system. [PDF]

Alzheimers Dement
Kargazhanov A, Aiken R, Hawkins K, Lopez R, Nawaz A, Srivastava G, Miller C, Bogen W, Long C, Morgan D, Guo X, Hickman J.   +11 more
europepmc   +1 more source

CaV1.2 dynamics in native male arterial myocytes

The Journal of Physiology, Volume 604, Issue 15, Page 6302-6323, 1 August 2026.
Abstract figure legend Proposed model of microtubule‐dependent CaV1.2 reorganization in vascular disease. Schematic illustration of microtubule‐mediated delivery and stabilization of CaV1.2 channels into enlarged plasma membrane clusters in response to Ang II or hyperglycaemia, promoting cooperative gating and enhanced Ca2+ influx. Abstract L‐type CaV1.
Miguel Martin‐Aragon Baudel, Hannah Voorhees, Arsalan U. Syed, Maryann K. Ferrara, Mary Horne, Johannes W. Hell, Luis F. Santana, Rose E. Dixon, Madeline Nieves‐Cintron, Manuel F. Navedo   +9 more
wiley   +1 more source

Fabrication and characterization of 3D-printed polyacrylonitrile scaffolds for the neural differentiation of mesenchymal stem cells via exosomes. [PDF]

J Biol Eng
Hoveizi E, Sayahi M.
europepmc   +1 more source

Gut‐Derived Sodium Butyrate Attenuates Liver Fibrosis by Inhibiting Aerobic Glycolysis via the HDAC3/c‐Myc Signaling Axis

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
This study explores the molecular mechanisms by which NaB ameliorates liver fibrosis from the perspectives of the gut–liver axis and metabolic reprogramming. In vivo and in vitro experiments demonstrate that gut‐derived NaB may alleviate liver injury and fibrosis by inhibiting hepatic stellate cell activation and aerobic glycolysis through the HDAC3/c ...
Yong Sun, Huayue Wu, Yutong Zhou, Pengsheng Yin, Long Wu, Haiyang Li, Shi Zuo, Zhe Yang, Kun Cao   +8 more
wiley   +1 more source

Cytology at the crossroads: Safeguarding equity in the molecular era. [PDF]

Cytojournal
Díaz Del Arco C.
europepmc   +1 more source

FGFR Inhibitor AZD4547 Disrupts Inflammatory CAF Crosstalk With Cancer Cells and Macrophages and Attenuates Metastasis in Pancreatic Cancer

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
This study demonstrates that FGFR‐targeted inhibition by AZD4547 in inflammatory cancer‐associated fibroblasts (iCAFs) intervenes into the tumor–stroma crosstalk. AZD4547 blocks IL‐1α–induced differentiation of pancreatic stellate cells into iCAFs, impairing iCAF‐driven tumor cell differentiation, migration, and M2 macrophage polarization. Consequently,
Ahmed M. R. H. Mostafa, Ahmed G. Hemdan, Franck Assayag, Jai Prakash   +3 more
wiley   +1 more source