Results 201 to 210 of about 166,510 (294)

Proteasomal-dependent endothelial P2Y₆ receptor downregulation as an adaptive mechanism limiting monocyte adhesion during intestinal schistosomiasis. [PDF]

Purinergic Signal
Oliveira NF, Monteiro MMLV, Crepaldi LD, Coutinho-Silva R, Savio LEB, Silva CLM.   +5 more
europepmc   +1 more source

SYK Signalling in NLRP3 Inflammasome‐Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG

European Journal of Immunology, Volume 56, Issue 5, May 2026.
IC‐mediated inflammatory response—the NLRP3 inflammasome activation, cytokine secretion, and antigen presentation depend on SYK signalling pathways in primary murine microglia. ABSTRACT Viral infections might trigger systemic inflammatory responses characterised by inflammasome activation and cytokine release, driven by immune complex (IC) formation ...
Kristina Mašalaitė, Milda Norkienė, Aurelija Žvirblienė, Asta Lučiūnaitė   +3 more
wiley   +1 more source

5-HT1B receptor agonists promote Schwann cell myelination. [PDF]

PLoS One
Kobayashi-Ujiie Y, Hiraki-Kamon K, Wakatsuki S, Araki T.   +3 more
europepmc   +1 more source

The Ubiquitin Ligase Zinc Finger SWIM Domain‐Containing Protein 8 Regulates Oligodendrocyte Development Through the Argonaute2/MicroRNA‐7 Axis

Glia, Volume 74, Issue 5, May 2026.
ZSWIM8, an E3 ubiquitin ligase that broadly targets IDR‐rich proteins, drives MiR‐7‐dependent AGO2 degradation and the turnover of many RBPs. Loss of ZSWIM8 leads to MiR‐7 accumulation in oligodendrocyte progenitor cells and myelination defects in the developing brain. ABSTRACT Proteostasis of proteins with intrinsically disordered regions (IDRs) is of
Jing Lei, Siming Zhong, Rong Fan, Xin Shu, Guan Wang, Jiansheng Guo, Shuting Xue, Luqian Zheng, Aiming Ren, Junfang Ji, Bing Yang, Shumin Duan, Zhiping Wang, Xing Guo   +13 more
wiley   +1 more source

Enigmatic Role of IL-31 in the Itch and Inflammation of Vernal Keratoconjunctivitis. [PDF]

Juntendo Med J
Okamoto M, Tominaga M, Mashimo K, Usui-Ouchi A, Ebihara N.   +4 more
europepmc   +1 more source

A Cationic Block Co‐Polymer for Gene Delivery in the Posterior Segment of the Eye

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
ABSTRACT Diseases of the back of the eye such as neovascular age‐related macular degeneration (nAMD) are vision threatening and treatment is burdensome for patients, often requiring ocular injections every other month. Injection risks and logistics lower patient compliance; however, even patients receiving optimal treatment can deteriorate.
Amber Monteiro, Odunayo O. Mugisho, Antonio de Souza, Lina Liu, Yosra Agban, Priyanka Agarwal, Avik Shome, Ilva D. Rupenthal, Heather Sheardown   +8 more
wiley   +1 more source

Orexin-A Inhibits Lipopolysaccharide-Induced Cell Migration in Cultured Mouse Astrocytes via Activation of Orexin 1 Receptor: Involvement of GABA Signaling. [PDF]

J Cell Biochem
Shin H, Choi SR, Kang DW, Lee H, Park J, Lee M, Bae M, Ryu Y, Kang SY, Chae CW, Kim HW.   +10 more
europepmc   +1 more source

Systemic Propagation of STING Signalling via Generation of Large Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Large extracellular vesicles (EVs) derived from tumour cells play important roles in tumour formation and progression. However, it remains unclear why malignant cells produce these EVs and how they act in vivo. We employ a well‐characterized Drosophila tumour model and demonstrate that large EV biogenesis from malignant cells is an ...
Jiae Lee, Annabel Vernon, Hyung Joon Park, Young V. Kwon   +3 more
wiley   +1 more source

Mitochondrial dynamics and function in neural differentiation: a systematic review. [PDF]

Eur J Med Res
Armat A, Pooladi A, Seyedoshohadaei SA, Moradveisi B, Khanyabzadeh M, Badri S, Rahimi Darehbagh R.   +6 more
europepmc   +1 more source

High‐Resolution Imaging Reveals Mitochondrial Protein Imbalance in Sperm of Oligoasthenospermic Men

Molecular Reproduction and Development, Volume 93, Issue 5, May 2026.
ABSTRACT Male infertility accounts for nearly half of global infertility cases and is often linked to poor sperm quality, such as oligospermia, asthenospermia, and teratospermia. Although the exact mechanisms remain unclear, mitochondria, which are critical for ATP production and reactive oxygen species generation during fertilization, are increasingly
Pauline Teixeira, Magalie Boguenet, Florence Pascaretti‐Grizon, Florence Manero, Solenn Plouzennec, Pierre‐Emmanuel Bouet, Pascal Reynier, Arnaud Chevrollier, Pascale May‐Panloup   +8 more
wiley   +1 more source