Results 191 to 200 of about 166,510 (294)

The Clinical Spectrum and Neurodevelopmental Pathogenesis of KPTN‐Related Disorder in a Mouse Model

Annals of Neurology, Volume 99, Issue 5, Page 1287-1302, May 2026.
Objective Pathogenic variants in Kaptin (KPTN) cause KPTN‐related disorder (KRD). KPTN modulates mTOR signaling activation within the KICSTOR complex in response to cellular amino acid levels. We define the clinical spectrum and investigate the developmental pathogenesis of KRD.
Lettie E. Rawlins, Philip H. Iffland II, John Page, Rebecca Z. Flessner, Soad M. Elziny, Irina Sbornova, Janice K. Babus, Sophie R. Bruckmeier, Ria Parikh, Merel Verhoeven, James Fasham, Joseph S. Leslie, Richard Caswell, Nishanka Ubeyratna, Olivia Wenger, Ethan M. Scott, John Schreiber, Steffen Syrbe, Annick Klabunde‐Cherwon, Martina Owens, Andrew H. Crosby, Emma L. Baple, Peter B. Crino, the KPTN Consortium, Andrea Seeley, Heather Rocha, Sabine Rudnick, Ulrich Schaatz, Tobias Haack, Eva Schwaibold, Caleb Bupp, Klaas Wierenga, John Schreiber, Thorkild Terkelsen, Sarina Kant, J. C. Herkert, Michael Wright, Boris Keren, Solveig Heide, Pamela Jackson, Pradeep Vasudevan, Helen Stewart, Perrine Charles, Andreas Hahn, Saskia Biskup, Inger‐Lise Mero, Martin Heier, Conny van Ravenswaaij‐Arts, Esther Nibbeling, Stephanie Efthymiou, Erum Afzal, Ian Ellis, Raza Maroofian, Almundher Al‐Maawali, David Coman, Anthony Morosini, Sajjad Biglari, Pooneh Nikuei, Saadet Mercimek‐Andrews, Prab Prabhakar, Raymond Louie, Kameryn Butler, Olivia Wenger, Ethan M. Scott, Andrea Seeley, Heather Rocha, Amber Begtrup, Sabine Rudnik, Ulrich Schatz, Tobias Haack, Eva Schwaibold, Caleb Bupp, Klaas Wierenga, John Schreiber, Thorkild Terkelsen, Sarina Kant, J. C. Herkert, Michael Wright, Boris Keren, Solveig Heide, Pamela Jackson, Pradeep Vasudevan, Helen Stewart, Perrine Charles, Andreas Hahn, Saskia Biskup, Inger‐Lise Mero, Martin Heier, Marijn Stokman, Conny van Ravenswaaij‐Arts, Esther Nibbeling, Stephanie Efthymiou, Erum Afzal, Kristina Zhelcheska, Henry Houlden, Ian Ellis, Reza Maroofian, Gholamreza Shariati, Hamid Galehdari, Almundher Al‐Maawali, Adila Al‐Kindi, Andrew Y. Shuen, Victoria Siu, Annick Klabunde‐Cherwon, Steffen Syrbe   +104 more
wiley   +1 more source

Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1

Annals of Neurology, Volume 99, Issue 5, Page 1173-1178, May 2026.
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan, Milo Fonville, Mabel Hoekstra, Rolf Fronczek, Joost Smolders, Dick F. Swaab   +5 more
wiley   +1 more source

Long-term survival of autologous adrenal medulla grafts in the great omentum of the rat [PDF]

, 1993
Gratzl, Manfred, Gratzl, Otmar, Mendelowitsch, Aminadav, Vereczkey, Csaba, Zhang, Tiang-Ming   +4 more
core   +1 more source

Modulatory Effect of Natural Antioxidants on Tissue Transglutaminase Levels in Olfactory Ensheathing Cells Exposed to Amyloid-β: Integrated Biochemical and Computational Analysis. [PDF]

Biofactors
Pellitteri R, Tomasella C, Chiacchio MA, Pappalardo M, Legnani L, Spatuzza M, Massaro A, Guccione S, Campisi A.   +8 more
europepmc   +1 more source

Tumor‐Immune‐On‐Chip to Evaluate Pathophysiological Feature of T Lymphocytes Expanded from Patient Tumors and Lymph Node Tissues

Cancer Medicine, Volume 15, Issue 5, May 2026.
3D Tumor‐Immune On‐Chip reveals patient‐derived tumor‐infiltrating lymphocytes (TILs) exhibit superior infiltration and cytotoxicity against colorectal cancer spheroids compared to lymph node T cells, providing a platform to study patient‐specific tumor‐immune interactions for developing personalized cancer immunotherapies.
Gyu‐Bon Cho, Hyun‐Joo Lee, You Jeong Heo, Jihoon Ko, Won‐Suk Lee, Sujin Hyung   +5 more
wiley   +1 more source

LPS-induced inflammation differentially affects endogenous Ca²⁺ activity in mouse and human iPSC-derived astrocytes. [PDF]

Mol Med
Müller FE, Ivanov F, Studt AC, Nitzsche I, Bahr FS, Krüger AL, Labus J, Singh G, Ponimaskin EG, Lenk K, Zeug A.   +10 more
europepmc   +1 more source

Shear Stress as a Driver of Retinal Müller Glia Survival and Fibrotic Reprogramming

Cell Biochemistry and Function, Volume 44, Issue 5, May 2026.
ABSTRACT The retina is highly influenced by mechanical cues such as intraocular fluid movement and blood flow, generating shear stress implicated in both retinal development and pathology. Müller glia, as retinal mechanosensors, are uniquely positioned to respond to such forces.
Laura Prieto‐López, Christian van Oterendorp, Elena Vecino, Xandra Pereiro   +3 more
wiley   +1 more source

Extracellular acidity and ATP modulate ion currents in human cumulus cells indicating possible roles as metabolic sensors of the follicular microenvironment. [PDF]

Physiol Rep
Biagini A, Gentile R, Corbucci C, Mariani M, Favilli A, Gerli S, Fioretti B.   +6 more
europepmc   +1 more source

High dopamine impairs early neuronal identity and morphology in human hippocampal progenitor cells. [PDF]

Front Cell Dev Biol
Ravji M, Mandal G, Batzu L, Thuret S.
europepmc   +1 more source

Phagocytic Mesothelial Cells in Pericardial Effusion Following Allogeneic Peripheral Blood Stem Cell Transplantation for Chronic Active Epstein–Barr Virus Infection: A Distinctive Cytomorphological and Immunocytochemical Case Study

Diagnostic Cytopathology, Volume 54, Issue 5, Page E136-E139, May 2026.
ABSTRACT Phagocytic activity of mesothelial cells is a rare phenomenon requiring careful differentiation from histiocytic hemophagocytosis to ensure appropriate patient management, as these phenomena could exhibit distinct clinical implications. In this study, we report a case of phagocytic mesothelial cells found in pericardial effusion that developed
Hidetoshi Satomi, Ayumi Ryu, Sei Murayama, Hiroya Kojima, Satoshi Tanada, Keiichiro Honma   +5 more
wiley   +1 more source