Results 211 to 220 of about 130,186 (296)

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Endothelial Nitric Oxide Synthase-Dependent Mechanism of Hydroxyurea-Induced S-Phase Arrest in Erythroid Cells. [PDF]

Antioxidants (Basel)
Dragojević T, Đikić D, Mojsilović S, Lazarević M, Milenković D, Ajtić OM, Živković E, Diklić M, Subotički T, Santibanez JF, Čokić VP, Vukotić M.   +11 more
europepmc   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Protocol for generating highly enriched sex-specific primary cortical astrocytes from individual mouse pups. [PDF]

STAR Protoc
Al-Jaf S, Ai EH, Wilson JA, Abd-Elrahman KS.   +3 more
europepmc   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, Volume 13, Issue 59, 23 October 2026.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Clusterin is enriched in plaque‐associated astrocytes and localizes to synapses in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION The clusterin gene (CLU) is a top genome‐wide association studies (GWAS) risk locus for Alzheimer's disease (AD) and elevated clusterin levels have been reported in AD biofluids and brain tissue. Despite growing interest in clusterin as a biomarker and therapeutic target, its cellular and subcellular localization in the human ...
Robert A. J. Byrne, Aurora Veteleanu, Hannah L. Cramp, Olivia G. Bacon, Kirsten L. Baillie, Matthew Bright, Rebekah S. Cooke, Gareth D. Fenn, Mariana Flores Castelán, Kok Yung Lee, Wioleta M. Zelek, B. Paul Morgan, Nikoleta Daskoulidou   +12 more
wiley   +1 more source

Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons. [PDF]

Aging Cell
Gerónimo-Olvera C, Scheeler SM, Aguirre CG, Vega-Hormazabal G, Garcia D, Wu L, Murad N, Schneider K, Wilson KA, Markov NT, Song S, Simons J, Gerencser AA, Parlan E, Mooney SD, Verdin E, Campisi J, Tracy TE, Furman D, Melov S, Ellerby LM.   +20 more
europepmc   +1 more source

Piezoelectric Nanocomposite Hydrogel for Wireless Neural Stimulation and Tissue Augmentation

Advanced NanoBiomed Research, Volume 6, Issue 10, October 2026.
A cell/tissue supporting piezoelectric hydrogel system (PZ‐gel) that incorporates ferroelectric, pyroelectric, and piezoelectric ceramic material barium titanate into an alginate/carboxymethyl chitosan hydrogel. The PZ‐gel can be sonoactivated for wireless neural cell and tissue stimulation, with the potential to be used as a stimulatory cell substrate
Mohammad Mohammadi, Eva Tomaskovic‐Crook, Peter C. Innis, Jeremy M. Crook   +3 more
wiley   +1 more source

Primary Human Papillomavirus Screening Versus Cytology for Detection of Cervical Intraepithelial Neoplasia Grade 2 or Higher in Poland: a Parallel-Group, Randomized Controlled Trial. [PDF]

Lancet Reg Health Eur
Nowakowski A, Macios A, Glinska P, Chmielewska A, Janik B, Jędrzejewska I, Klimiuk A, Chmielik E, Bobkiewicz P, Kapuśniak E, Podolski J, Prokurat E, Arbyn M, Kamiński MF.   +13 more
europepmc   +1 more source

Basal Marker ΔNp63α Is Enriched in Pancreatic Cancer Metastases but Not in Primary Tumors Post‐Chemotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Cancer cells within a single pancreatic ductal adenocarcinoma (PDAC) are most often heterogeneous in their expression of the basal or classical transcriptional program. Predominance of the basal subtype has been associated with poorer patient outcomes and increased resistance to chemotherapy.
Daniel H. Ryan, Yuuki Ohara, Michael J. Kruhlak, Xianyu Zhang, Miao Lin, Chin‐Hsien Tai, Christine Alewine   +6 more
wiley   +1 more source