Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Eight novel N‐phenylpyrazoline derivatives bearing chlorothiophene moieties were synthesized and evaluated for anticancer activity against T47D, MCF7, and WiDr cell lines. Compound 2g showed the strongest cytotoxicity against WiDr cells (IC50 = 19.63 µg/mL) with the highest selectivity index (665.88), highlighting its potential as a selective ...
Nikma Farismatur Riza +4 more
wiley +1 more source
Correction: Raeker et al. Reduced Retinal Pigment Epithelial Autophagy Due to Loss of Rab12 Prenylation in a Human iPSC-RPE Model of Choroideremia. <i>Cells</i> 2024, <i>13</i>, 1068. [PDF]
CellsRaeker MÖ +7 more
europepmc +1 more source
Physiological Postnatal Neurogenesis, Development, and Maturation in the Regenerable Retina
Journal of Comparative Neurology, Volume 534, Issue 10, October 2026.Retinal structural remodeling from hatchlings to preadults in axolotls involves neurogenesis, cell redistribution, increased expression of photopsins and connexins, and enhanced inhibitory regulation. The peripheral retina of young animals possesses more columnar undifferentiated cells, resembling the columnar DCX‐positive progenitor cells in the ...
Vivian Y. Pang +4 more
wiley +1 more source
Reduction of Microglial Reactivity by Cannabidiol: Preliminary Data Obtained in an Astrocyte-Microglia Co-Culture Model of Inflammation. [PDF]
Pharmaceuticals (Basel)Schönfelder L +5 more
europepmc +1 more source
ER Stress Regulates HIV Tat and Alcohol‐Induced NLRP6 Activation in Astrocytes
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.HIV Tat and ethanol synergistically induce ER stress in astrocytes, activating an ER stress‐NLRP6 inflammasome axis that drives caspase‐1 activation and IL‐1β/IL‐18 release. Targeting ER stress or NLRP6 effectively suppresses astrocytic neuroinflammation, identifying a novel therapeutic pathway for alcohol‐exacerbated NeuroHIV.
Seema Singh +3 more
wiley +1 more source
Correlation of retinal imaging with presence of inner limiting membrane pores in idiopathic epiretinal gliosis. [PDF]
Int J Retina VitreousVogt D +8 more
europepmc +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.Traumatic brain injury (TBI) induces acute, sex‐specific activation of endoplasmic reticulum (ER) stress, inflammatory signaling, and ferroptotic mechanisms within brain microvascular endothelial cells (BMECs). Administration of dexmedetomidine (DEX) produces both sex‐dependent and sex‐independent modulatory effects on BMECs, prominently suppressing ...
Yara Mashal +6 more
wiley +1 more source
Development and validation of a long-term co-maturation protocol for human stem cell-derived microglia and neuronal networks. [PDF]
Stem Cell ReportsMordelt A +12 more
europepmc +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.Human iPSC‐derived cortical neurons carrying a PSEN1 Alzheimer's mutation exhibit mitochondrial dysfunction, hyperexcitability, amyloid and tau pathology, and impaired synaptic plasticity. The Deanna Protocol, an anaplerotic metabolic supplement, rescues these deficits, supporting energy restoration as a viable therapeutic strategy for Alzheimer's ...
Leticia Keler Soares +6 more
wiley +1 more source
Diagnostic Cytopathology, Volume 54, Issue 10, Page 731-737, October 2026.ABSTRACT Clear cell sarcoma of soft tissue (CCSST) with malignant effusion is a rare yet clinically aggressive appearance, which may pose a diagnostic pitfall with its overlapping cytomorphologic features with metastatic melanoma and carcinoma.
William H. Wu +2 more
wiley +1 more source