Results 281 to 290 of about 863,721 (336)

Re‐PERFUSE: Phase 1b study of AZD3427, a novel relaxin receptor agonist, on renal perfusion in HFrEF patients

ESC Heart Failure, EarlyView.
Abstract Aims Renal impairment frequently coexists with heart failure (HF) and is associated with increased risk of poor clinical outcomes. This highlights the urgent need for therapies targeting both cardiac and renal dysfunction. AZD3427, a long‐acting recombinant fusion protein and relaxin analogue that selectively activates the relaxin family ...
Marcin Ufnal, Macarena P. Quintana‐Hayashi, Kathleen Connolly, Daniel Pettersen, Zsolt Cselényi, Aurelija Jucaite, Magnus Schou, Andrea Varrone, Melanie Chan, Lars H. Lund   +9 more
wiley   +1 more source

Novel Compound Heterozygous Mutations in HOIP Result in Autoinflammation and Immunodeficiency. [PDF]

J Clin Immunol
Wang L, Xiao J, Gan R, Tang X, Wu J.
europepmc   +1 more source

Global, regional and national burden of epilepsy in adolescents aged 10–19 years from 1990 to 2021: An analysis for the Global Burden of Disease Study 2021

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy, a neurological disorder characterized by recurrent seizures, imposes multidimensional burdens on adolescents aged 10–19 years, including disrupted education, restricted social participation, and diminished socioeconomic prospects.
Ziran Zhou, Shuting Chen, Yang Gao, Guo Li   +3 more
wiley   +1 more source

Intractable thrombocytopenia in a patient with atypical ataxia-telangiectasia: a case report. [PDF]

BMC Med Genomics
Gu C, Cui Q, Luo W, Zhang S, Shu J, Chen S.   +5 more
europepmc   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Gut microbiota of sub-Saharan Africa infants exposed to antiretroviral therapy: Scoping review. [PDF]

Afr J Prim Health Care Fam Med
Mudhluli TE, Mashingaidze-Mano R, Chitsike I, Manasa J, Hall LJ, Gomo E, Zhou DT.   +6 more
europepmc   +1 more source

Targeting NAT10 Inhibits Hepatocarcinogenesis via ac4C‐Mediated SMAD3 mRNA Stability

Exploration, EarlyView.
This study demonstrates that elevated N‐acetyltransferase 10 (NAT10) expression stabilizes SMAD3 mRNA through ac4C modification, promoting the progression of hepatocellular carcinoma (HCC). NAT10 also activates the TGF‐β signaling pathway, facilitating epithelial‐to‐mesenchymal transition and inhibiting anoikis. Furthermore, the authors develop a small‐
Yigan Zhang, Yanbin Dong, Shuwen Chen, Hao Deng, Weiru Yu, Bonan Chen, Minjie Chen, Wanglong Liu, Xiao Tan, Jiaxin Ni, Daniel Rigden, Xuan Wang, Wuhua Zhou, Jia Meng, Juan Chen, Yuanchao Xue, Zhongji Meng   +16 more
wiley   +1 more source

Knowledge, Attitude and Practice Regarding HIV/AIDS Among Antenatal Women Attending a Tertiary Care Center in Western India. [PDF]

Cureus
Verma A, Bharti R, Kashyap M.
europepmc   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, EarlyView.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

When Less Could be More: Successful Treatment of Granulomatous Lymphocytic Interstitial Lung Disease with Azathioprine. [PDF]

Eur J Case Rep Intern Med
López AL, Fernández Romero DS.
europepmc   +1 more source