Results 261 to 270 of about 1,114,238 (404)

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Anti-granulocyte macrophage colony-stimulating factor autoantibodies: A rising cause of infectious diseases. [PDF]

PLoS Pathog
Wang SY, Lo YF, Tsai YH, Ku CL.
europepmc   +1 more source

Teleocidins and Benzolactams Inhibit Cell Killing by Human Immunodeficiency Virus Type 1 (HIV-I).

, 1994
Yasuyuki ENDO, M Ohno, Masaaki HIRANO, Tamio FUJIWARA, Akihiko Sato, Yorio Hinuma, Koichi Shudo   +6 more
openalex   +2 more sources

The crossroads of autoimmunity and immunodeficiency: Lessons from polygenic traits and monogenic defects.

Journal of Allergy and Clinical Immunology, 2016
B. Grimbacher, K. Warnatz, P. Yong, A. Korganow, H. Peter   +4 more
semanticscholar   +1 more source

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still's Disease‐like Autoinflammatory Syndrome

Arthritis &Rheumatology, Accepted Article.
Objectives Still's Disease represents a prototypical polygenic systemic autoinflammatory diseases (SAIDs), characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still's disease remains unreported.
Longfang Chen, Qihua Dai, Yu Xiao, Jialin Dai, Mengyan Wang, Yuning Ma, Yujie Shen, Zhimo Xu, Jianfen Meng, Xia Chen, Da Yi, Yue Sun, Hui Shi, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Tingting Liu, Jialin Teng, Chengde Yang, Jinchao Jia, Qiongyi Hu   +23 more
wiley   +1 more source

Autoimmunity and inborn errors of immunity: a complex coexistence. [PDF]

Front Immunol
Elamine A, Benhsaien I, Ailal F, Hbibi M, Fahi M, Bousfiha AA, El Bakkouri J.   +6 more
europepmc   +1 more source

Immunodeficiency [PDF]

Archives of Disease in Childhood, 1977
openaire   +1 more source

Gene therapy for immunodeficiency due to adenosine deaminase deficiency.

New England Journal of Medicine, 2009
A. Aiuti, F. Cattaneo, S. Galimberti, U. Benninghoff, B. Cassani, Luciano Callegaro, S. Scaramuzza, G. Andolfi, Massimiliano Mirolo, I. Brigida, A. Tabucchi, F. Carlucci, M. Eibl, M. Aker, S. Slavin, H. Al-Mousa, Abdulaziz Al Ghonaium, A. Ferster, A. Duppenthaler, L. Notarangelo, U. Wintergerst, R. Buckley, M. Bregni, S. Marktel, M. Valsecchi, P. Rossi, F. Ciceri, R. Miniero, C. Bordignon, M. Roncarolo   +29 more
semanticscholar   +1 more source

Machine Learning to Predict Remission Between Six and 24 Months in Rheumatoid Arthritis: Insights from the JAK‐pot Collaboration

Arthritis &Rheumatology, Accepted Article.
Objective To develop, externally validate, and simplify a machine‐learning (ML) model to predict remission between six and 24 months in rheumatoid arthritis (RA) patients initiating TNF inhibitors, JAK inhibitors, IL‐6 inhibitors, abatacept, or rituximab, using data from 11 international registries in the JAK‐pot collaboration.
Zubeyir Salis, Denis Mongin, Denis Choquette, Louis Coupal, Catalin Codreanu, Florenzo Iannone, Roberto Caporali, Tore K Kvien, Sella Provan, Ruth Fritsch‐Stork, Dan Nordström, Nina Trokovic, Karel Pavelka, Jakub Závada, Ana Rodrigues, Ziga Rotar, Prodromos Sidiropoulos, Irini Flouri, Céline Lamacchia, Michele Iudici, Delphine Courvoisier, Kim Lauper, Axel Finckh   +22 more
wiley   +1 more source

Pharmacokinetic modelling of intravenous immunoglobulin in children with primary immunodeficiencies and secondary antibody deficiencies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Children with primary immunodeficiency (PID) and secondary antibody deficiency (SAD) often require immunoglobulin replacement therapy due to low plasma immunoglobulin G (IgG) levels and recurrent infections. Existing pharmacokinetic models for immunoglobulin in PID patients predominantly focus on adults, with limited attention to ...
Iek Leng Cheng, Zhong Hui Huang, Austen Worth, Claire Booth, Joseph F. Standing   +4 more
wiley   +1 more source