Results 71 to 80 of about 614,575 (264)

Transplantation outcomes for severe combined immunodeficiency, 2000-2009.

New England Journal of Medicine, 2014
BACKGROUND The Primary Immune Deficiency Treatment Consortium was formed to analyze the results of hematopoietic-cell transplantation in children with severe combined immunodeficiency (SCID) and other primary immunodeficiencies. Factors associated with a
S. Pai, B. Logan, Linda M. Griffith, R. Buckley, R. Parrott, C. Dvorak, N. Kapoor, I. C. Hanson, A. Filipovich, S. Jyonouchi, K. Sullivan, T. Small, L. Burroughs, S. Skoda-Smith, A. Haight, A. Grizzle, M. Pulsipher, K. Chan, R. Fuleihan, E. Haddad, B. Loechelt, V. Aquino, A. Gillio, Jeffrey H Davis, A. Knutsen, Angela R. Smith, T. Moore, M. Schroeder, F. Goldman, J. Connelly, M. Porteus, Q. Xiang, W. Shearer, T. Fleisher, D. Kohn, J. Puck, L. Notarangelo, M. Cowan, R. O'reilly   +38 more
semanticscholar   +1 more source

Gene therapy for immunodeficiency due to adenosine deaminase deficiency.

New England Journal of Medicine, 2009
BACKGROUND We investigated the long-term outcome of gene therapy for severe combined immunodeficiency (SCID) due to the lack of adenosine deaminase (ADA), a fatal disorder of purine metabolism and immunodeficiency.
A. Aiuti, F. Cattaneo, S. Galimberti, U. Benninghoff, B. Cassani, Luciano Callegaro, S. Scaramuzza, G. Andolfi, Massimiliano Mirolo, I. Brigida, A. Tabucchi, F. Carlucci, M. Eibl, M. Aker, S. Slavin, H. Al-Mousa, Abdulaziz Al Ghonaium, A. Ferster, A. Duppenthaler, L. Notarangelo, U. Wintergerst, R. Buckley, M. Bregni, S. Marktel, M. Valsecchi, P. Rossi, F. Ciceri, R. Miniero, C. Bordignon, M. Roncarolo   +29 more
semanticscholar   +1 more source

ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality

Disease Models & Mechanisms, 2023
Elena Sindram, Andrés Caballero-Oteyza, Naoko Kogata, Shaina Chor Mei Huang, Zahra Alizadeh, Laura Gámez-Díaz, Mohammad Reza Fazlollhi, Xiao Peng, Bodo Grimbacher, Michael Way, Michele Proietti   +10 more
doaj   +1 more source

The ABACHAI clinical trial protocol: Safety and efficacy of abatacept (s.c.) in patients with CTLA-4 insufficiency or LRBA deficiency: A non controlled phase 2 clinical trial

Contemporary Clinical Trials Communications, 2022
Background: Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) insufficiency and lipopolysaccharide-responsive and beige-like anchor protein (LRBA) deficiency are both complex immune dysregulation syndromes with an underlying regulatory T cell ...
Máté Krausz, Annette Uhlmann, Ina Caroline Rump, Gabriele Ihorst, Sigune Goldacker, Georgios Sogkas, Sara Posadas-Cantera, Reinhold Schmidt, Manuel Feißt, Laia Alsina, Ingunn Dybedal, Mike Recher, Klaus Warnatz, Bodo Grimbacher   +13 more
doaj  

Immunologic responses to bacteriophage ϕX 174 in immunodeficiency diseases [PDF]

, 1971
Hans D. Ochs, Starkey D. Davis, Ralph Wedgwood   +2 more
openalex   +1 more source

Active human immunodeficiency virus protease is required for viral infectivity.

Proceedings of the National Academy of Sciences of the United States of America, 1988
Retroviral proteins are synthesized as polyprotein precursors that undergo proteolytic cleavages to yield the mature viral proteins. The role of the human immunodeficiency virus (HIV) protease in the viral replication cycle was examined by use of a site ...
N. Kohl, E. Emini, W. Schleif, L. Davis, J. C. Heimbach, R. A. Dixon, E. Scolnick, I. Sigal   +7 more
semanticscholar   +1 more source

Is It Safe to Switch From Intravenous Immunoglobulin to Subcutaneous Immunoglobulin in Patients With Common Variable Immunodeficiency and Autoimmune Thrombocytopenia?

Frontiers in Immunology, 2018
BackgroundA significant amount of common variable immunodeficiency (CVID) patients manifest with autoimmunity. Particularly, autoimmune thrombocytopenia (AITP) is commonly seen.
Philipp Scheuerlein, Larissa Pietsch, Nadezhda Camacho-Ordonez, Nadezhda Camacho-Ordonez, Veronika Reiser, Smita Patel, Siobhan O. Burns, Klaus Warnatz, Bodo Grimbacher, Bodo Grimbacher   +9 more
doaj   +1 more source

Quantitative Immunoassay of Adenosine Deaminase in Combined Immunodeficiency Disease [PDF]

, 1977
Dennis A. Carson, Randall M. Goldblum, J. Edwin Seegmiller   +2 more
openalex   +1 more source

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy.

New England Journal of Medicine, 2002
BACKGROUND X-linked severe combined immunodeficiency due to a mutation in the gene encoding the common gamma (gamma(c)) chain is a lethal condition that can be cured by allogeneic stem-cell transplantation.
S. Hacein-Bey-Abina, F. Le Deist, F. Carlier, C. Bouneaud, C. Hue, J. de Villartay, A. Thrasher, N. Wulffraat, R. Sorensen, S. Dupuis-Girod, A. Fischer, E. Davies, W. Kuis, Lilly Leiva, M. Cavazzana‐Calvo   +14 more
semanticscholar   +1 more source

Human Immunodeficiency Disease: Impairment of Cellular Interactions Leading to Abnormal Mediator Production in Mixed Lymphocyte Culture Reaction [PDF]

, 1977
Andrzej Górski, Bo Dupont, John A. Hansen, Bijan Safai, Savita Pahwa, Robert A. Good   +5 more
openalex   +1 more source