Results 61 to 70 of about 607,896 (303)

Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study

BMC Public Health, 2018
Background Respiratory tract infections (RTIs) are a major morbidity factor contributing largely to health care costs and individual quality of life. The aim of the study was to test whether obesity (BMI ≥ 30 kg/m2) is one of the risk factors underlying ...
Livia Maccioni, Susanne Weber, Magdeldin Elgizouli, Anne-Sophie Stoehlker, Ilona Geist, Hans-Hartmut Peter, Werner Vach, Alexandra Nieters   +7 more
doaj   +1 more source

Altered Microbiota, Impaired Quality of Life, Malabsorption, Infection, and Inflammation in CVID Patients With Diarrhoea

Frontiers in Immunology, 2020
Background: Diarrhoea is the commonest gastrointestinal symptom in patients with common variable immunodeficiency (CVID).Objective: The aim of this study was to describe the prevalence and clinical presentation of chronic and recurrent diarrhoea in the ...
Cornelia M. van Schewick, Cornelia M. van Schewick, Christina Nöltner, Svenja Abel, Svenja Abel, Siobhan O. Burns, Sarita Workman, Andrew Symes, David Guzman, Michele Proietti, Alla Bulashevska, Fernando Moreira, Veronika Soetedjo, David M. Lowe, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +18 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Pregnancy, child bearing and prevention of giving birth to the affected children in patients with primary immunodeficiency disease; a case-series

BMC Pregnancy and Childbirth, 2018
Background Patients with primary immunodeficiency disease (PID) who survive to adulthood and willing to have a child mostly are worried whether their disease affects their fertility and/or pregnancy and also if their child would be predisposed to PID ...
Saba Sheikhbahaei, Roya Sherkat, Nadezhda Camacho-Ordonez, Razie Khoshnevisan, Asadollah Kalantari, Mansour Salehi, Seyed Saman Nazemian, Mohammad Hossein Nasr-esfahani, Christophe Klein   +8 more
doaj   +1 more source

Modeling MyD88 Deficiency In Vitro Provides New Insights in Its Function

Frontiers in Immunology, 2020
Inherited defects in MyD88 and IRAK4, two regulators in Toll-like receptor (TLR) signaling, are clinically highly relevant, but still incompletely understood.
Nils Craig-Mueller, Nils Craig-Mueller, Nils Craig-Mueller, Ruba Hammad, Ruba Hammad, Ruba Hammad, Roland Elling, Roland Elling, Roland Elling, Jamal Alzubi, Jamal Alzubi, Barbara Timm, Barbara Timm, Julia Kolter, Julia Kolter, Nele Knelangen, Nele Knelangen, Christien Bednarski, Christien Bednarski, Birgitta Gläser, Sandra Ammann, Sandra Ammann, Zoltán Ivics, Judith Fischer, Judith Fischer, Carsten Speckmann, Carsten Speckmann, Carsten Speckmann, Klaus Schwarz, Nico Lachmann, Nico Lachmann, Stephan Ehl, Stephan Ehl, Stephan Ehl, Thomas Moritz, Thomas Moritz, Philipp Henneke, Philipp Henneke, Philipp Henneke, Philipp Henneke, Toni Cathomen, Toni Cathomen, Toni Cathomen   +42 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets

Frontiers in Immunology
The Epstein–Barr virus (EBV) is usually acquired during infancy as an asymptomatic infection and persists throughout life in a latent state under the control of the host immune system.
Maria Giovanna Desimio, Daniela Angela Covino, Caterina Cancrini, Caterina Cancrini, Margherita Doria   +4 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source