Results 61 to 70 of about 1,114,238 (404)

Immunodeficiency-associated lymphoproliferative disorders: time for reappraisal?

Blood, 2018
Immunodeficiency-associated lymphoproliferative disorders (IA-LPDs) are pathologically and clinically heterogeneous. In many instances, similar features are shared by a spectrum of IA-LPDs in clinically diverse settings.
Y. Natkunam, D. Gratzinger, A. Chadburn, J. Goodlad, J. C. Chan, J. Said, E. Jaffe, D. de Jong   +7 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets

Frontiers in Immunology
The Epstein–Barr virus (EBV) is usually acquired during infancy as an asymptomatic infection and persists throughout life in a latent state under the control of the host immune system.
Maria Giovanna Desimio, Daniela Angela Covino, Caterina Cancrini, Caterina Cancrini, Margherita Doria   +4 more
doaj   +1 more source

The ABACHAI clinical trial protocol: Safety and efficacy of abatacept (s.c.) in patients with CTLA-4 insufficiency or LRBA deficiency: A non controlled phase 2 clinical trial

Contemporary Clinical Trials Communications, 2022
Background: Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) insufficiency and lipopolysaccharide-responsive and beige-like anchor protein (LRBA) deficiency are both complex immune dysregulation syndromes with an underlying regulatory T cell ...
Máté Krausz, Annette Uhlmann, Ina Caroline Rump, Gabriele Ihorst, Sigune Goldacker, Georgios Sogkas, Sara Posadas-Cantera, Reinhold Schmidt, Manuel Feißt, Laia Alsina, Ingunn Dybedal, Mike Recher, Klaus Warnatz, Bodo Grimbacher   +13 more
doaj   +1 more source

Epstein–Barr Virus+ Smooth Muscle Tumors as Manifestation of Primary Immunodeficiency Disorders

Frontiers in Immunology, 2018
Epstein–Barr virus positive (EBV+) smooth muscle tumors (SMTs) constitute a very rare oncological entity. They usually develop in the context of secondary immunodeficiency caused by human immunodeficiency virus infection or immunosuppressive treatment ...
T. Magg, T. Schober, C. Walz, J. Ley-Zaporozhan, F. Facchetti, C. Klein, F. Hauck   +6 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. [PDF]

, 2017
Most studies of HIV latency focus on the peripheral population of resting memory T cells, but the brain also contains a distinct reservoir of HIV-infected cells in microglia, perivascular macrophages, and astrocytes.
Alvarez-Carbonell, David, Cannon, Paula M, Chateau, Morgan, Karn, Jonathan, Llewellyn, George N   +4 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The interplay of comorbidity, disability, and physical activity among older adults living with HIV: insights from the CHANGE HIV study

BMC Geriatrics
Background Advances in treatment and care have extended the life expectancy of people living with HIV. Nevertheless, comorbidities are common and may result in health-related challenges, known as disability, in everyday life.
Tai-Te Su, Kelly K. O’Brien, Alice Zhabokritsky, Bryan Boyachuk, Sharon Walmsley, Correlates of Healthy Aging in Geriatric HIV (CHANGE HIV) study team   +5 more
doaj   +1 more source

Primary Immunodeficiency Diseases: An Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency

Front. Immun., 2011
We report the updated classification of primary immunodeficiency diseases, compiled by the ad hoc Expert Committee of the International Union of Immunological Societies.
W. Al-Herz, A. Bousfiha, J. Casanova, T. Chatila, M. Conley, C. Cunningham-Rundles, Amos Etzioni, J. Franco, H. Gaspar, S. Holland, C. Klein, S. Nonoyama, H. Ochs, E. Oksenhendler, C. Picard, J. Puck, K. Sullivan, M. Tang   +17 more
semanticscholar   +1 more source