Results 41 to 50 of about 607,896 (303)

Mutation of Mycobacterium tuberculosis and Implications for Using Whole-Genome Sequencing for Investigating Recent Tuberculosis Transmission

Frontiers in Public Health, 2022
Tuberculosis (TB) control programs use whole-genome sequencing (WGS) of Mycobacterium tuberculosis (Mtb) for detecting and investigating TB case clusters. Existence of few genomic differences between Mtb isolates might indicate TB cases are the result of
Kristin N. Nelson, Sarah Talarico, Shameer Poonja, Clinton J. McDaniel, Martin Cilnis, Alicia H. Chang, Kala Raz, Wendy S. Noboa, Lauren Cowan, Tambi Shaw, James Posey, Benjamin J. Silk   +11 more
doaj   +1 more source

Clinical characteristics and lung function in older children vertically infected with Human Immunodeficiency Virus in Malawi [PDF]

, 2015
T. M. was funded by the Commonwealth scholarship, with research costs from a grant fom Helse Nord Northern Norway Regional Health Authority. E. L. C., R. A. F., and J. R. are supported by Wellcome Trust Fellowships (Senior Fellowship in Clinical Sciences
Webb, Emily L, Rylance, Sarah J, van Oosterhout, Joep J, Emily L. Webb, Mwalukomo, Thandie, Anderson, Suzanne, O'Hare, Bernadette, Elizabeth L. Corbett, Corbett, Elizabeth L, Webb, Emily, Jamie Rylance, Ferrand, Rashida A., van Oosterhout, Joep J., Corbett, Elizabeth L., Sarah J. Rylance, Ferrand, Rashida A, Rashida A. Ferr, Rylance, Jamie, Joep J. Van Oosterhout, Rylance, Sarah, O'Hare, Bernadette Ann-Marie, Suzanne Anderson, Ie Mwalukomo   +22 more
core   +1 more source

Scoring Thoracic CT Scans of Patients with NFKB1-Related Disease for Clinical Management and Treatment Studies Using Four Parameters (Adapted from the Hartmann Score)

Journal of Human Immunity
BackgroundNFKB1 encodes the p105/p50 nuclear factor-kappa-B (NF-κB1) transcription factor. Heterozygous mutations in NFKB1 are associated with NFKB1-related disease, including granulomatous-lymphocytic interstitial lung disease (GLILD) or similar lung ...
Katharina Thoma, Manfred Fliegauf, Bärbel Keller, Maximilian Frederik Russe, Gabriele Müller, Michele Proietti, Andres Caballero Garcia de Oteyza, Pavla Mrovecova, Helene Kraus, Klaus Warnatz, Nadezhda Camacho Ordonez, Aleksandra Hirsch, Christoph Geier, Máté Krausz, Sigune Goldacker, Natalie Frede, Stephan Ehl, Sarah Salou, Shahrzad Bakhtiar, Maria Fasshauer, Michael Borte, Oliver Hausmann, Faranaz Atschekzei, Georgios Sogkas, Ansgar Schulz, Bodo Grimbacher, Prerana Agarwal   +26 more
doaj   +1 more source

Combined immunodeficiencies

Jornal de Pediatria, 2021
Inborn Errors of Immunity (IEI), also known as primary immunodeficiencies, correspond to a heterogeneous group of congenital diseases that primarily affect immune response components. The main clinical manifestations comprise increased susceptibility to infections, autoimmunity, inflammation, allergies and malignancies.
Carolina Sanchez Aranda, Rafaela Rola Guimarães, Mariana de Gouveia-Pereira Pimentel   +2 more
openaire   +5 more sources

Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus [PDF]

, 2002
Feline CXCR4 and CCR5 were expressed in feline cells as fusion proteins with enhanced green fluorescent protein (EGFP). Expression of the EGFP fusion proteins was localized to the cell membrane, and surface expression of CXCR4 was confirmed by using a ...
Hosie, M.J., Willett, B.J., Cannon, C.A.
core   +1 more source

Development of a Disease Activity Score to Assess Treatment Success in Patients with NFKB1 Mutations

Journal of Human Immunity
BackgroundNFKB1 encodes for the p105/p50 nuclear factor-kappa-B (NF-kB1) transcription factors. Heterozygous mutations in NFKB1 may lead to NF-kB1 insufficiency, which may result in a multiorgan disease. Here, we aimed to develop a disease activity score
Katharina Thoma, Pia Hassunah, Manfred Fliegauf, Gabriele Müller, Andres Caballero Garcia de Oteyza, IPavla Mrovecova, Helene Kraus, Prerana Agarwal, Maximilian Frederik Russe, Birgit Sawitzki, Lev Petrov, Katrin Vogt, Nadezhda Nadezhda Camacho Ordonez, Aleksandra Hirsch, Christoph B. Geier, Máté Krausz, Sigune Goldacker, Natalie Frede, Stephan Ehl, Sarah Salou, Ansgar Schulz, Shahrzad Bakhtiar, Maria Fasshauer, Oliver Hausmann, Anja-Dorothee Hüfner, Martin Stanulla, Anna Luijendijk, Faranaz Atschekzei, Georgios Sogkas, Ulrich Salzer, Baerbel Keller, Michele Proietti, Klaus Warnatz, Bodo Grimbacher   +33 more
doaj   +1 more source

Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency

Frontiers in Immunology, 2019
Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency. Patients with CVID are prone to recurrent bacterial infection due to the failure of adequate immunoglobulin production.
Zoya Eskandarian, Zoya Eskandarian, Manfred Fliegauf, Manfred Fliegauf, Alla Bulashevska, Michele Proietti, Rosie Hague, Cristian Roberto Smulski, Desirée Schubert, Klaus Warnatz, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +14 more
doaj   +1 more source

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source

LRBA regulates actin cytoskeleton dynamics through NMIIA during B cell immune responses

EMBO Reports
Patients with lipopolysaccharide-responsive beige-like anchor protein (LRBA) deficiency typically suffer from severe B cell dysfunction. However, the underlying mechanisms remain incompletely understood.
Elena Sindram, Juan Eduardo Montero-Hernández, Quentin Frenger, Hannah van Dijk, Anna Lang, Vanessa Zeidler, Rebecca Marsiske, Manuel Rhiel, Kerstin Geiger, Tatjana I Cornu, Emily M Mace, Volker Spindler, Joern Dengjel, Frédéric Gros, Bodo Grimbacher, Fernando E Sepulveda, Yolanda R Carrasco, Virginia Andreani, Laura Gámez-Díaz   +18 more
doaj   +1 more source

Molecular changes associated with increased TNF-α-induced apoptotis in naïve (TN) and central memory (TCM) CD8+ T cells in aged humans

Immunity & Ageing, 2018
Background Progressive T cell decline in aged humans is associated with a deficiency of naïve (TN) and central memory (TCM) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in TN and TCM T cells in aged ...
Sudhir Gupta, Houfen Su, Sudhanshu Agrawal, Sastry Gollapudi   +3 more
doaj   +1 more source