Results 31 to 40 of about 619,127 (304)

Selective expansion of viral variants following experimental transmission of a reconstituted feline immunodeficiency virus quasispecies [PDF]

, 2013
Following long-term infection with virus derived from the pathogenic GL8 molecular clone of feline immunodeficiency virus (FIV), a range of viral variants emerged with distinct modes of interaction with the viral receptors CD134 and CXCR4, and ...
Margaret J Hosie, Martin Kraase (276419), McMonagle Elizabeth, Kraase, M., Varela, M., Mariana Varela (81646), Kraase Martin, Nicola Logan (276420), Mariana Varela, Hosie Margaret J., Brian J Willett, Brian J. Willett (276418), Logan Nicola, Elizabeth McMonagle (276421), Willett Brian J., Hosie, M.J., Varela Mariana, Nicola Logan, Logan, N., Willett, B.J., McMonagle, E., Margaret J. Hosie (276422), Elizabeth McMonagle, Martin Kraase   +23 more
core   +1 more source

Combined immunodeficiencies

Jornal de Pediatria, 2021
Inborn Errors of Immunity (IEI), also known as primary immunodeficiencies, correspond to a heterogeneous group of congenital diseases that primarily affect immune response components. The main clinical manifestations comprise increased susceptibility to infections, autoimmunity, inflammation, allergies and malignancies.
Carolina Sanchez Aranda, Rafaela Rola Guimarães, Mariana de Gouveia-Pereira Pimentel   +2 more
openaire   +5 more sources

A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction [PDF]

, 2008
Feline immunodeficiency virus (FIV) targets helper T cells by attachment of the envelope glycoprotein (Env) to CD134, a subsequent interaction with CXCR4 then facilitating the process of viral entry.
Margaret J Hosie, Ayman Samman, Willett Brian J, Samman, Ayman, Logan Nicola, Brian J Willett, Samman Ayman, McMonagle, Elizabeth L., Hosie Margaret J, Logan, Nicola, McMonagle Elizabeth L, Nicola Logan, Hosie, Margaret J., Willett, Brian J., Elizabeth L McMonagle   +14 more
core   +1 more source

Development of a Disease Activity Score to Assess Treatment Success in Patients with NFKB1 Mutations

Journal of Human Immunity
BackgroundNFKB1 encodes for the p105/p50 nuclear factor-kappa-B (NF-kB1) transcription factors. Heterozygous mutations in NFKB1 may lead to NF-kB1 insufficiency, which may result in a multiorgan disease. Here, we aimed to develop a disease activity score
Katharina Thoma, Pia Hassunah, Manfred Fliegauf, Gabriele Müller, Andres Caballero Garcia de Oteyza, IPavla Mrovecova, Helene Kraus, Prerana Agarwal, Maximilian Frederik Russe, Birgit Sawitzki, Lev Petrov, Katrin Vogt, Nadezhda Nadezhda Camacho Ordonez, Aleksandra Hirsch, Christoph B. Geier, Máté Krausz, Sigune Goldacker, Natalie Frede, Stephan Ehl, Sarah Salou, Ansgar Schulz, Shahrzad Bakhtiar, Maria Fasshauer, Oliver Hausmann, Anja-Dorothee Hüfner, Martin Stanulla, Anna Luijendijk, Faranaz Atschekzei, Georgios Sogkas, Ulrich Salzer, Baerbel Keller, Michele Proietti, Klaus Warnatz, Bodo Grimbacher   +33 more
doaj   +1 more source

Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription.

, 2004
The increasing numbers of human immunodeficiency virus type 1 (HIV-1) strains that exhibit resistance to antiretroviral agents used at present require the development of new effective antiretroviral compounds.
Bates, Paula J, B. R. Kosloff, Priebe, W, G. M. Shaw, Kosloff, Barry R, W. Priebe, Levy, David N, O. Kutsch, P. J. Bates, Shaw, George M, Kutsch, Olaf, Benveniste, Etty N, E. N. Benveniste, Decker, Julie, D. N. Levy, J. Decker   +15 more
core   +1 more source

Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency

Frontiers in Immunology, 2019
Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency. Patients with CVID are prone to recurrent bacterial infection due to the failure of adequate immunoglobulin production.
Zoya Eskandarian, Zoya Eskandarian, Manfred Fliegauf, Manfred Fliegauf, Alla Bulashevska, Michele Proietti, Rosie Hague, Cristian Roberto Smulski, Desirée Schubert, Klaus Warnatz, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +14 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

LRBA regulates actin cytoskeleton dynamics through NMIIA during B cell immune responses

EMBO Reports
Patients with lipopolysaccharide-responsive beige-like anchor protein (LRBA) deficiency typically suffer from severe B cell dysfunction. However, the underlying mechanisms remain incompletely understood.
Elena Sindram, Juan Eduardo Montero-Hernández, Quentin Frenger, Hannah van Dijk, Anna Lang, Vanessa Zeidler, Rebecca Marsiske, Manuel Rhiel, Kerstin Geiger, Tatjana I Cornu, Emily M Mace, Volker Spindler, Joern Dengjel, Frédéric Gros, Bodo Grimbacher, Fernando E Sepulveda, Yolanda R Carrasco, Virginia Andreani, Laura Gámez-Díaz   +18 more
doaj   +1 more source

Molecular changes associated with increased TNF-α-induced apoptotis in naïve (TN) and central memory (TCM) CD8+ T cells in aged humans

Immunity & Ageing, 2018
Background Progressive T cell decline in aged humans is associated with a deficiency of naïve (TN) and central memory (TCM) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in TN and TCM T cells in aged ...
Sudhir Gupta, Houfen Su, Sudhanshu Agrawal, Sastry Gollapudi   +3 more
doaj   +1 more source

Cytomegaloviruses and Macrophages—Friends and Foes From Early on?

Frontiers in Immunology, 2020
Starting at birth, newborn infants are exposed to numerous microorganisms. Adaptation of the innate immune system to them is a delicate process, with potentially advantageous and harmful implications for health development.
Sebastian Baasch, Sebastian Baasch, Zsolt Ruzsics, Philipp Henneke, Philipp Henneke   +4 more
doaj   +1 more source