Results 51 to 60 of about 619,127 (304)

Altered Microbiota, Impaired Quality of Life, Malabsorption, Infection, and Inflammation in CVID Patients With Diarrhoea

Frontiers in Immunology, 2020
Background: Diarrhoea is the commonest gastrointestinal symptom in patients with common variable immunodeficiency (CVID).Objective: The aim of this study was to describe the prevalence and clinical presentation of chronic and recurrent diarrhoea in the ...
Cornelia M. van Schewick, Cornelia M. van Schewick, Christina Nöltner, Svenja Abel, Svenja Abel, Siobhan O. Burns, Sarita Workman, Andrew Symes, David Guzman, Michele Proietti, Alla Bulashevska, Fernando Moreira, Veronika Soetedjo, David M. Lowe, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +18 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Pregnancy, child bearing and prevention of giving birth to the affected children in patients with primary immunodeficiency disease; a case-series

BMC Pregnancy and Childbirth, 2018
Background Patients with primary immunodeficiency disease (PID) who survive to adulthood and willing to have a child mostly are worried whether their disease affects their fertility and/or pregnancy and also if their child would be predisposed to PID ...
Saba Sheikhbahaei, Roya Sherkat, Nadezhda Camacho-Ordonez, Razie Khoshnevisan, Asadollah Kalantari, Mansour Salehi, Seyed Saman Nazemian, Mohammad Hossein Nasr-esfahani, Christophe Klein   +8 more
doaj   +1 more source

Modeling MyD88 Deficiency In Vitro Provides New Insights in Its Function

Frontiers in Immunology, 2020
Inherited defects in MyD88 and IRAK4, two regulators in Toll-like receptor (TLR) signaling, are clinically highly relevant, but still incompletely understood.
Nils Craig-Mueller, Nils Craig-Mueller, Nils Craig-Mueller, Ruba Hammad, Ruba Hammad, Ruba Hammad, Roland Elling, Roland Elling, Roland Elling, Jamal Alzubi, Jamal Alzubi, Barbara Timm, Barbara Timm, Julia Kolter, Julia Kolter, Nele Knelangen, Nele Knelangen, Christien Bednarski, Christien Bednarski, Birgitta Gläser, Sandra Ammann, Sandra Ammann, Zoltán Ivics, Judith Fischer, Judith Fischer, Carsten Speckmann, Carsten Speckmann, Carsten Speckmann, Klaus Schwarz, Nico Lachmann, Nico Lachmann, Stephan Ehl, Stephan Ehl, Stephan Ehl, Thomas Moritz, Thomas Moritz, Philipp Henneke, Philipp Henneke, Philipp Henneke, Philipp Henneke, Toni Cathomen, Toni Cathomen, Toni Cathomen   +42 more
doaj   +1 more source

Immunologic markers of progression to acquired immunodeficiency syndrome are time-dependent and illness-specific [PDF]

, 1992
Krämer A, Biggar RJ, Hampl H, et al. Immunologic markers of progression to acquired immunodeficiency syndrome are time-dependent and illness-specific. American Journal of Epidemiology.
Biggar, Robert J., Hampl, Hartmut, Fuchs, Dietmar, Krämer, Alexander ; https://orcid.org/, Goedert, James J., Friedman, Robert M., Wachter, Helmut   +6 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets

Frontiers in Immunology
The Epstein–Barr virus (EBV) is usually acquired during infancy as an asymptomatic infection and persists throughout life in a latent state under the control of the host immune system.
Maria Giovanna Desimio, Daniela Angela Covino, Caterina Cancrini, Caterina Cancrini, Margherita Doria   +4 more
doaj   +1 more source

COVID-19 in a patient with Good's syndrome and in 13 patients with common variable immunodeficiency

Clinical Immunology Communications, 2021
Antibody deficiencies constitute the majority of primary immunodeficiencies in adults. These patients have a well-established increased risk of bacterial infections but there is a lack of knowledge regarding the relative risks upon contracting COVID-19 ...
Hannes Lindahl, C I Edvard Smith, Peter Bergman   +2 more
doaj   +1 more source

Clinical characteristics and lung function in older children vertically infected with Human Immunodeficiency Virus in Malawi [PDF]

, 2015
T. M. was funded by the Commonwealth scholarship, with research costs from a grant fom Helse Nord Northern Norway Regional Health Authority. E. L. C., R. A. F., and J. R. are supported by Wellcome Trust Fellowships (Senior Fellowship in Clinical Sciences
Webb, Emily L, Rylance, Sarah J, van Oosterhout, Joep J, Emily L. Webb, Mwalukomo, Thandie, Anderson, Suzanne, O'Hare, Bernadette, Elizabeth L. Corbett, Corbett, Elizabeth L, Webb, Emily, Jamie Rylance, Ferrand, Rashida A., van Oosterhout, Joep J., Corbett, Elizabeth L., Sarah J. Rylance, Ferrand, Rashida A, Rashida A. Ferr, Rylance, Jamie, Joep J. Van Oosterhout, Rylance, Sarah, O'Hare, Bernadette Ann-Marie, Suzanne Anderson, Ie Mwalukomo, O'Hare, Bernadette Ann-Marie; id_orcid   +23 more
core   +1 more source