Results 1 to 10 of about 7,578 (214)

Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID) [PDF]

Frontiers in Immunology, 2023
IntroductionCommon variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency. CVID is a heterogeneous disorder with a presumed multifactorial etiology. Intravenous or subcutaneous immunoglobulin replacement therapy (IgRT)
Giuseppe Spadaro, Remo Poto, Stefania Loffredo   +2 more
exaly   +7 more sources

What Works When Treating Granulomatous Disease in Genetically Undefined CVID? A Systematic Review [PDF]

Frontiers in Immunology, 2020
BackgroundGranulomatous disease is reported in at least 8–20% of patients with common variable immunodeficiency (CVID). Granulomatous disease mainly affects the lungs, and is associated with significantly higher morbidity and mortality.
Willem Dik, Virgil Dalm, Joris Van Montfrans   +2 more
exaly   +5 more sources

Clinical and immunological differentiation of isolated IgG and combined IgG & IgM deficiencies from common variable immunodeficiency [PDF]

Frontiers in Immunology
ObjectiveTo assess the clinical relevance of diagnosing and classifying isolated IgG deficiency and combined IgG/IgM deficiency separately from CVID.MethodsIn a retrospective cohort of patients with primary hypogammaglobulinemia, we evaluated and ...
Yagmur Dogru, Faranaz Atschekzei, Faranaz Atschekzei, Damla Dogru, Torsten Witte, Torsten Witte, Georgios Sogkas, Georgios Sogkas   +7 more
doaj   +2 more sources

Patients With Common Variable Immunodeficiency (CVID) Show Higher Gut Bacterial Diversity and Levels of Low-Abundance Genes Than the Healthy Housemates

Frontiers in Immunology, 2021
Common variable immunodeficiency (CVID) is a clinically and genetically heterogeneous disorder with inadequate antibody responses and low levels of immunoglobulins including IgA that is involved in the maintenance of the intestinal homeostasis.
Tomáš Freiberger, Juraj Bosak, Jiří Litzman   +2 more
exaly   +3 more sources

Investigating serum free light chains in patients with common variable immunodeficiency disorder in compare with other immunodeficiency diseases [PDF]

Scientific Reports
Serum free light chains (sFLCs) have recently been introduced as a diagnostic biomarker in common variable immunodeficiency (CVID) patients. Most patients with CVID have undetectable or lower levels of sFLCs compared to people with other types of immune ...
Mohammad Hassan Bemanian, Majid Khoshmirsafa, Mina Ahmadi, Mohamad Nabavi, Saba Arshi, Zahra Chavoshzadeh, Sima Shokri, Morteza Fallahpour, Negin Jafariaghdam, Fatemeh Afrashteh, Samane Asefi, Mehrnaz Mesdaghi, Samin Sharafian   +12 more
doaj   +2 more sources

CXCL13 as a Biomarker of Complex Common Variable Immunodeficiency [PDF]

Journal of Human Immunity
Common variable immunodeficiency (CVID) is a group of heterogeneous disorders with common denominators of impaired antibody production and function and recurrent infections. Currently, prognostic biomarkers for CVID are limited.
Ioasaf Karafotias, Helene Martini, Charlotte V. Lee, Terrence T.J. Hunter, Padmalal Gurugama, Mary Guckian, Rachael Steven, Stephen Jolles, Mark Peakman, David Fear, Mohammad A.A. Ibrahim   +10 more
doaj   +2 more sources

Gut Microbiome and Common Variable Immunodeficiency: Few Certainties and Many Outstanding Questions

Frontiers in Immunology, 2021
Common variable immunodeficiency (CVID) is the most common symptomatic primary antibody immunodeficiency, characterized by reduced serum levels of IgG, IgA, and/or IgM. The vast majority of CVID patients have polygenic inheritance.
Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Remo Poto, Remo Poto, Gianluca Ianiro, Alessandra Punziano, Alessandra Punziano, Gianni Marone, Gianni Marone, Gianni Marone, Antonio Gasbarrini, Giuseppe Spadaro, Giuseppe Spadaro   +13 more
doaj   +1 more source

Common variable immunodeficiency—an independent risk factor for atherosclerotic cardiovascular diseases

Frontiers in Cardiovascular Medicine, 2023
Atherosclerosis, a disease of chronic inflammation of the arterial wall, is the main cause of most cardiovascular diseases (CVDs). Common variable immunodeficiency (CVID), a group of diseases characterized by frequent infections due to defective antibody
Juho Mattila, Niina Pitkänen, Hannu Järveläinen, Hannu Järveläinen   +3 more
doaj   +1 more source

Defective peripheral B cell selection in common variable immune deficiency patients with autoimmune manifestations

Cell Reports, 2023
Summary: Common variable immune deficiency (CVID) is a heterogeneous disorder characterized by recurrent infections, low levels of serum immunoglobulins, and impaired vaccine responses.
Vanda Friman, Isabella Quinti, Alexey N. Davydov, Mikhail Shugay, Chiara Farroni, Erik Engström, Shirin Pour Akaber, Sabina Barresi, Ahmed Mohamed, Federica Pulvirenti, Cinzia Milito, Guido Granata, Ezio Giorda, Sara Ahlström, Johanna Karlsson, Emiliano Marasco, Valentina Marcellini, Chiara Bocci, Simona Cascioli, Marco Scarsella, Ganesh Phad, Andreas Tilevik, Marco Tartaglia, Mats Bemark, Dmitriy M. Chudakov, Rita Carsetti, Ola Grimsholm   +26 more
doaj   +1 more source

B- and T-Cell Subset Abnormalities in Monogenic Common Variable Immunodeficiency

Frontiers in Immunology, 2022
Common variable immunodeficiency (CVID) is a heterogeneous group of inborn errors of immunity characterized by reduced serum concentrations of different immunoglobulin isotypes.
Saba Fekrvand, Shaghayegh Khanmohammadi, Hassan Abolhassani, Hassan Abolhassani, Hassan Abolhassani, Reza Yazdani, Reza Yazdani, Reza Yazdani   +7 more
doaj   +1 more source