Results 1 to 10 of about 5,467 (160)

Cytokine Dysregulation Despite Immunoglobulin Replacement Therapy in Common Variable Immunodeficiency (CVID)

Frontiers in Immunology, 2023
IntroductionCommon variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency. CVID is a heterogeneous disorder with a presumed multifactorial etiology. Intravenous or subcutaneous immunoglobulin replacement therapy (IgRT)
Giuseppe Spadaro, Remo Poto, Stefania Loffredo   +2 more
exaly   +3 more sources

What Works When Treating Granulomatous Disease in Genetically Undefined CVID? A Systematic Review

Frontiers in Immunology, 2020
BackgroundGranulomatous disease is reported in at least 8–20% of patients with common variable immunodeficiency (CVID). Granulomatous disease mainly affects the lungs, and is associated with significantly higher morbidity and mortality.
Willem A Dik, Virgil A S H Dalm, Hanna IJspeert   +2 more
exaly   +3 more sources

Patients With Common Variable Immunodeficiency (CVID) Show Higher Gut Bacterial Diversity and Levels of Low-Abundance Genes Than the Healthy Housemates

Frontiers in Immunology, 2021
Common variable immunodeficiency (CVID) is a clinically and genetically heterogeneous disorder with inadequate antibody responses and low levels of immunoglobulins including IgA that is involved in the maintenance of the intestinal homeostasis.
Tomáš Freiberger, Jiří Litzman, David Šmajs   +2 more
exaly   +3 more sources

Gut Microbiome and Common Variable Immunodeficiency: Few Certainties and Many Outstanding Questions

Frontiers in Immunology, 2021
Common variable immunodeficiency (CVID) is the most common symptomatic primary antibody immunodeficiency, characterized by reduced serum levels of IgG, IgA, and/or IgM. The vast majority of CVID patients have polygenic inheritance.
Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Remo Poto, Remo Poto, Gianluca Ianiro, Alessandra Punziano, Alessandra Punziano, Gianni Marone, Gianni Marone, Gianni Marone, Antonio Gasbarrini, Giuseppe Spadaro, Giuseppe Spadaro   +13 more
doaj   +1 more source

Common variable immunodeficiency—an independent risk factor for atherosclerotic cardiovascular diseases

Frontiers in Cardiovascular Medicine, 2023
Atherosclerosis, a disease of chronic inflammation of the arterial wall, is the main cause of most cardiovascular diseases (CVDs). Common variable immunodeficiency (CVID), a group of diseases characterized by frequent infections due to defective antibody
Juho Mattila, Niina Pitkänen, Hannu Järveläinen, Hannu Järveläinen   +3 more
doaj   +1 more source

Defective peripheral B cell selection in common variable immune deficiency patients with autoimmune manifestations

Cell Reports, 2023
Summary: Common variable immune deficiency (CVID) is a heterogeneous disorder characterized by recurrent infections, low levels of serum immunoglobulins, and impaired vaccine responses.
Vanda Friman, Isabella Quinti, Alexey N. Davydov, Mikhail Shugay, Chiara Farroni, Erik Engström, Shirin Pour Akaber, Sabina Barresi, Ahmed Mohamed, Federica Pulvirenti, Cinzia Milito, Guido Granata, Ezio Giorda, Sara Ahlström, Johanna Karlsson, Emiliano Marasco, Valentina Marcellini, Chiara Bocci, Simona Cascioli, Marco Scarsella, Ganesh Phad, Andreas Tilevik, Marco Tartaglia, Mats Bemark, Dmitriy M. Chudakov, Rita Carsetti, Ola Grimsholm   +26 more
doaj   +1 more source

B- and T-Cell Subset Abnormalities in Monogenic Common Variable Immunodeficiency

Frontiers in Immunology, 2022
Common variable immunodeficiency (CVID) is a heterogeneous group of inborn errors of immunity characterized by reduced serum concentrations of different immunoglobulin isotypes.
Saba Fekrvand, Shaghayegh Khanmohammadi, Hassan Abolhassani, Hassan Abolhassani, Hassan Abolhassani, Reza Yazdani, Reza Yazdani, Reza Yazdani   +7 more
doaj   +1 more source

Genomic crossroads between non-Hodgkin’s lymphoma and common variable immunodeficiency

Frontiers in Immunology, 2022
Common variable immunodeficiency (CVID) represents the largest group of primary immunodeficiencies that may manifest with infections, inflammation, autoimmunity, and cancer, mainly B-cell non-Hodgkin’s lymphoma (NHL).
Kissy Guevara-Hoyer, Kissy Guevara-Hoyer, Kissy Guevara-Hoyer, Jesús Fuentes-Antrás, Jesús Fuentes-Antrás, Eduardo de la Fuente-Muñoz, Eduardo de la Fuente-Muñoz, Eduardo de la Fuente-Muñoz, Miguel Fernández-Arquero, Miguel Fernández-Arquero, Miguel Fernández-Arquero, Fernando Solano, Pedro Pérez-Segura, Esmeralda Neves, Esmeralda Neves, Alberto Ocaña, Alberto Ocaña, Rebeca Pérez de Diego, Rebeca Pérez de Diego, Silvia Sánchez-Ramón, Silvia Sánchez-Ramón, Silvia Sánchez-Ramón   +21 more
doaj   +1 more source

Clinical and laboratory parameter analysis in patients with common Variable Immunodeficiency [PDF]

Medicinski Podmladak, 2022
Introduction: Common Variable Immunodeficiency (CVID) is the most prevalent primary immunodeficiency in adult population. The diagnosis is based on low concentration of at least 2 immunoglobulin classes, mostly IgG, with low IgA and/or IgM.
Krtinić Danka, Stojanović Maja
doaj  

Importance of cellular immunity link for efficiency of replacement therapy in common variable immune deficiency

Медицинская иммунология, 2020
Lifetime use of IgG replacement therapy  is the standard of CVID treatment. However, full control over stabilization of chronic infection loci is not always achieved, even if this therapy  is continuously applied.
L. P. Sizyakina, I. I. Andreeva, D. I. Danilova   +2 more
doaj   +1 more source