Results 51 to 60 of about 1,052,494 (379)

Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys

Frontiers in Immunology, 2021
The membrane attack complex—also known as C5b-9—is the end-product of the classical, lectin, and alternative complement pathways. It is thought to play an important role in the pathogenesis of various kidney diseases by causing cellular injury and tissue
Jacob J. E. Koopman, Jacob J. E. Koopman, Mieke F. van Essen, Helmut G. Rennke, Aiko P. J. de Vries, Cees van Kooten   +5 more
doaj   +1 more source

Bullous pemphigoid: Associating with the multifaceted phenomenon of koebner

Journal of Dermatology and Dermatologic Surgery, 2022
Koebner phenomenon (KP) or isomorphic phenomenon often helps in diagnosis of certain conditions and often reflects disease activity. Although commonly reported with psoriasis, vitiligo, and lichen planus, KP has been occasional reported with other ...
Sudhir U. K. Nayak, Shukriti D Shenoi, S Smitha Prabhu, Raghavendra Rao   +3 more
doaj   +1 more source

Validation of multiplex immunofluorescence panels using multispectral microscopy for immune-profiling of formalin-fixed and paraffin-embedded human tumor tissues

Scientific Reports, 2017
Immune-profiling is becoming an important tool to identify predictive markers for the response to immunotherapy. Our goal was to validate multiplex immunofluorescence (mIF) panels to apply to formalin-fixed and paraffin-embedded tissues using a set of ...
E. Parra, N. Uraoka, Mei Jiang, Pamela Cook, D. Gibbons, M. Forget, C. Bernatchez, C. Haymaker, I. Wistuba, J. Rodriguez-Canales   +9 more
semanticscholar   +1 more source

Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer [PDF]

, 2013
Background: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also
A Ho-Pun-Cheung, A Merlo, Ana Maria Waaga-Gasser, Andreas Rosenwald, C Loddenkemper, Christoph-Thomas Germer, E Sato, Eva Meier, F Ichihara, FA Sinicrope, FL Greene, H Groux, H Lu, H Suzuki, H Tao, HL Weiner, Igor Tsaur, J Shimizu, JD Fontenot, Jun Li, LM Ebert, M Viguier, Maria Lazariotou, Martin Gasser, Martin Grimm, ME Winerdal, Mia Kim, MJ Sack, N Chaput, N Hiraoka, N Kobayashi, P Correale, P Salama, P Yu, Roman Blaheta, S Hinz, S Ladoire, S Onizuka, T Alvaro, Tanja Grimmig, TL Whiteside, Uwe Heemann, V Karanikas, W Zou, WH Wang, WS Lee   +45 more
core   +3 more sources

The Suprachiasmatic Nucleus of the Dromedary Camel (Camelus dromedarius): Cytoarchitecture and Neurochemical Anatomy

Frontiers in Neuroanatomy, 2017
In mammals, biological rhythms are driven by a master circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Recently, we have demonstrated that in the camel, the daily cycle of environmental temperature is able to entrain the ...
Khalid El Allali, Mohamed R. Achaâban, Mohammed Piro, Mohammed Ouassat, Etienne Challet, Mohammed Errami, Nouria Lakhdar-Ghazal, André Calas, Paul Pévet   +8 more
doaj   +1 more source

Actin, α-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells [PDF]

, 1975
During the spreading of a population of rat embryo cells, approximately 40% of the cells develop a strikingly regular network which precedes the formation of the straight actin filament bundles seen in the fully spread out cells.
Lazarides, Elias
core   +1 more source

Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: A new potential target for antifibrotic therapy [PDF]

, 2018
Background: Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules ...
Berardicurti O., Carubbi F., Ciccia F., Cipriani P., Di Bartolomeo S., Di Benedetto P., Giacomelli R., Guggino G., Liakouli V., Panzera N., Ruscitti P., Triolo G.   +11 more
core   +1 more source

Tissue eosinophilia and eosinophil degranulation in Riedel's invasive fibrous thyroiditis. [PDF]

, 1996
The etiology of Riedel's invasive fibrous thyroiditis (IFT) has remained obscure. This rare disorder has been confused in the past with the more common fibrous variant of Hashimoto's disease.
Bahn, R. S., Gleich, G. J., Goellner, J. R., Hay, I. D., Heufelder, Armin E.   +4 more
core   +1 more source

Automated Quantitative Analysis of ex vivo Blood-Brain Barrier Permeability Using Intellesis Machine-Learning

Frontiers in Neuroscience, 2021
BackgroundAn increase in blood brain barrier permeability commonly precedes neuro-inflammation and cognitive impairment in models of dementia. Common methods to estimate capillary permeability have potential confounders, or require laborious and ...
Michael Nesbit, Michael Nesbit, John C. Mamo, John C. Mamo, Maimuna Majimbi, Maimuna Majimbi, Virginie Lam, Virginie Lam, Ryusuke Takechi, Ryusuke Takechi   +9 more
doaj   +1 more source

Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23. [PDF]

, 2017
Primordial germ cells (PGCs) are the earliest embryonic progenitors in the germline. Correct formation of PGCs is critical to reproductive health as an adult.
Chen, Di, Clark, Amander T, Gkountela, Sofia, Hennebold, Jon D, Liu, Wanlu, Orwig, Kyle E, Sosa, Enrique, Sukhwani, Meena   +7 more
core   +2 more sources