Results 41 to 50 of about 723,902 (263)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Photobleaching alters the morphometric analysis of fluorescently labeled neurons and microglial cells

Pathology and Oncology Research
Photobleaching of immunofluorescence signal is a well-known phenomenon, however, its impact on derived parameters characterizing number and shape of different cell types in tissue sections is less understood. Our aim was to determine whether the duration
Tamás F. Polgár, Tamás F. Polgár, Krisztina Spisák, Krisztina Spisák, Zalán Kádár, Nora Alodah, Gabor J. Szebeni, Kata Klein, Roland Patai, László Siklós, Bernát Nógrádi, Bernát Nógrádi   +11 more
doaj   +1 more source

Overview of Multiplex Immunohistochemistry and Immunofluorescence Techniques 
in the Lung Cancer Immunotherapy

Chinese Journal of Lung Cancer, 2021
Lung cancer is the most common malignancy and is a major public health problem worldwide. Programmed cell death receptor 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors provide a new treatment strategy for non-small cell lung cancer (NSCLC ...
Wenjia SUN, Jianya ZHOU, Jianying ZHOU
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Localization of the therapeutic targets for endothelin receptor antagonists and sodium-glucose co-transporter 2 inhibitors in the chronic liver disease, primary sclerosing cholangitis

Frontiers in Pharmacology
IntroductionPrimary sclerosing cholangitis (PSC) is a chronic liver disease of unknown cause contributing to cirrhosis and cancer but has no cure. PSC is characterized by inflammation within ductal fibrosis, progressive bile duct narrowing and loss, with
Rhoda E. Kuc, Anna L. Paterson, Thomas L. Williams, William T. H. Gelson, William T. H. Gelson, Peter J. Greasley, Phil Ambery, Janet J. Maguire, Anthony P. Davenport   +8 more
doaj   +1 more source

Neuroanatomy of melanocortin-4 receptor pathway in the mouse brain

Open Life Sciences, 2020
Melanocortin-4 receptors (MC4Rs) are key regulators of energy homeostasis and adipose deposition in the central nervous system. Considering that MC4R expression regions and function-related research mainly focus on the paraventricular nucleus (PVN ...
Wang Kun, Mao Wei, Zhang Xiaoyu, Zhao Yufei, Fan Kuikui, Pan Deng, Liu Haodong, Li Penghui, Hai Rihan, Du Chenguang   +9 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The diagnosis of Chlamydia trachomatis cervical infection among students by using classical and molecular methods [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2013
Introduction. Chlamydia trachomatis is the most common cause of sexually transmitted disease. The possibility of serious complications may be prevented by early detection of the bacteria on the uterine cervix by the application of sensitive and ...
Tomanović Snežana, Čukić Ivan, Obradović Marija, Ćurčić Nađa, Petrović-Milinković Anđela, Đukić Slobodanka   +5 more
doaj   +1 more source

Use of Immunofluorescence Technique to Perform a Quantitative Analysis of Masseter Muscle Fibers in Unilateral Posterior Crossbite: A Pilot Study

Applied Sciences, 2021
Unilateral posterior crossbite is a type of malocclusion that involves morpho-functional characteristics of masticatory muscle, such as the masseter: electrophysiological data have shown that the affected side works less than the contralateral muscle ...
Giovanna Vermiglio, Mariagrazia Piancino, Michele Runci Anastasi, Giacomo Picciolo, Antonio Centofanti, Giuseppe Santoro, Mariachiara Malandrino, Giuseppina Cutroneo, Giuseppe Anastasi   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source