Results 21 to 30 of about 594,133 (261)

Sialic acid accelerates the electrophoretic velocity of injured dorsal root ganglion neurons

Neural Regeneration Research, 2015
Peripheral nerve injury has been shown to result in ectopic spontaneous discharges on soma and injured sites of sensory neurons, thereby inducing neuropathic pain.
Chen-xu Li, Guo-ying Ma, Min-fang Guo, Ying Liu   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Varied Presentations and Clinical Outcomes of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposit: An Indian Series of Five Patients

Indian Journal of Kidney Diseases
Background: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a unique and rare entity which can have a variety of presentations ranging from nephrotic syndrome to rapidly progressive renal failure (RPRF).
Uttayan Chakrabarti, Manish Chaturvedy, Arghya Majumdar, Nitin Kumar Bajpai, Aasma Nalwa, Tapabrata Das, Arpit Agarwal, Rajesh Jhorawat   +7 more
doaj   +1 more source

N-thioalkylcarbazoles derivatives as new anti-proliferative agents: synthesis, characterisation and molecular mechanism evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Synthetic or natural carbazole derivatives constitute an interesting class of heterocycles, which showed several pharmaceutical properties and occupied a promising place as antitumour tools in preclinical studies. They target several cellular key-points,
Maria Stefania Sinicropi, Domenico Iacopetta, Camillo Rosano, Rosario Randino, Anna Caruso, Carmela Saturnino, Noemi Muià, Jessica Ceramella, Francesco Puoci, Manuela Rodriquez, Pasquale Longo, Maria Rosaria Plutino   +11 more
doaj   +1 more source

TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions

Retrovirology, 2011
Background The TRIM5 proteins are cellular restriction factors that prevent retroviral infection in a species-specific manner. Multiple experiments indicate that restriction activity requires accessory host factors, including E2-enzymes.
Lukic Zana, Hausmann Stéphane, Sebastian Sarah, Rucci Justin, Sastri Jaya, Robia Seth L, Luban Jeremy, Campbell Edward M   +7 more
doaj   +1 more source

THE OF IMMUNOFLUORESCENCE IN DIAGNOSIS AND PROGNOSIS OF GLOMERULOPATHIES WITH EXTRACAPILLARY PROLIFERATION

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
Objective. To evaluate the immune complex expression detected by immunofluorescence in order to establish the diagnosis and predict the course of glomerulopathies with extracapillary proliferation. Material and methods.
Dmitrieva M. V., Letkovskaya T. A., Savosh V. V., Bragina Z. N.   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Molecular characterization of cDNA coding for 33.5 and 41 kDa oocyst and sporocyst proteins that are differentially regulated in different strains of Eimeria maxima

Frontiers in Veterinary Science
Eimeria maxima (APU1 and APU2) differ in virulence for chickens, due in part to the greater fecundity of the former. In a previous study, RNA-seq was used to identify a transcripts upregulated in E. maxima APU1 compared to E. maxima APU2.
Mark C. Jenkins, Carolyn Parker, Andrew Jansen, Marianne Dias Papadopoulos, Matthew S. Tucker   +4 more
doaj   +1 more source

Quantitative Visualization of Hypoxia and Proliferation Gradients Within Histological Tissue Sections

Frontiers in Bioengineering and Biotechnology, 2019
The formation of hypoxic microenvironments within solid tumors is known to contribute to radiation resistance, chemotherapy resistance, immune suppression, increased metastasis, and an overall poor prognosis.
Mark Zaidi, Mark Zaidi, Fred Fu, Dan Cojocari, Trevor D. McKee, Bradly G. Wouters, Bradly G. Wouters   +6 more
doaj   +1 more source

Layer-Specific Vesicular Glutamate Transporter 1 Immunofluorescence Levels Delineate All Layers of the Human Hippocampus Including the Stratum lucidum

Frontiers in Cellular Neuroscience, 2021
The hippocampal formation consists of the Ammon’s horn (cornu Ammonis with its regions CA1-4), dentate gyrus, subiculum, and the entorhinal cortex.
Sarah Woelfle, Sarah Woelfle, Tobias M. Boeckers, Tobias M. Boeckers   +3 more
doaj   +1 more source