Results 31 to 40 of about 723,902 (263)

Varied Presentations and Clinical Outcomes of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposit: An Indian Series of Five Patients

Indian Journal of Kidney Diseases
Background: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a unique and rare entity which can have a variety of presentations ranging from nephrotic syndrome to rapidly progressive renal failure (RPRF).
Uttayan Chakrabarti, Manish Chaturvedy, Arghya Majumdar, Nitin Kumar Bajpai, Aasma Nalwa, Tapabrata Das, Arpit Agarwal, Rajesh Jhorawat   +7 more
doaj   +1 more source

N-thioalkylcarbazoles derivatives as new anti-proliferative agents: synthesis, characterisation and molecular mechanism evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Synthetic or natural carbazole derivatives constitute an interesting class of heterocycles, which showed several pharmaceutical properties and occupied a promising place as antitumour tools in preclinical studies. They target several cellular key-points,
Maria Stefania Sinicropi, Domenico Iacopetta, Camillo Rosano, Rosario Randino, Anna Caruso, Carmela Saturnino, Noemi Muià, Jessica Ceramella, Francesco Puoci, Manuela Rodriquez, Pasquale Longo, Maria Rosaria Plutino   +11 more
doaj   +1 more source

TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions

Retrovirology, 2011
Background The TRIM5 proteins are cellular restriction factors that prevent retroviral infection in a species-specific manner. Multiple experiments indicate that restriction activity requires accessory host factors, including E2-enzymes.
Lukic Zana, Hausmann Stéphane, Sebastian Sarah, Rucci Justin, Sastri Jaya, Robia Seth L, Luban Jeremy, Campbell Edward M   +7 more
doaj   +1 more source

THE OF IMMUNOFLUORESCENCE IN DIAGNOSIS AND PROGNOSIS OF GLOMERULOPATHIES WITH EXTRACAPILLARY PROLIFERATION

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
Objective. To evaluate the immune complex expression detected by immunofluorescence in order to establish the diagnosis and predict the course of glomerulopathies with extracapillary proliferation. Material and methods.
Dmitrieva M. V., Letkovskaya T. A., Savosh V. V., Bragina Z. N.   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Molecular characterization of cDNA coding for 33.5 and 41 kDa oocyst and sporocyst proteins that are differentially regulated in different strains of Eimeria maxima

Frontiers in Veterinary Science
Eimeria maxima (APU1 and APU2) differ in virulence for chickens, due in part to the greater fecundity of the former. In a previous study, RNA-seq was used to identify a transcripts upregulated in E. maxima APU1 compared to E. maxima APU2.
Mark C. Jenkins, Carolyn Parker, Andrew Jansen, Marianne Dias Papadopoulos, Matthew S. Tucker   +4 more
doaj   +1 more source

Quantitative Visualization of Hypoxia and Proliferation Gradients Within Histological Tissue Sections

Frontiers in Bioengineering and Biotechnology, 2019
The formation of hypoxic microenvironments within solid tumors is known to contribute to radiation resistance, chemotherapy resistance, immune suppression, increased metastasis, and an overall poor prognosis.
Mark Zaidi, Mark Zaidi, Fred Fu, Dan Cojocari, Trevor D. McKee, Bradly G. Wouters, Bradly G. Wouters   +6 more
doaj   +1 more source

Layer-Specific Vesicular Glutamate Transporter 1 Immunofluorescence Levels Delineate All Layers of the Human Hippocampus Including the Stratum lucidum

Frontiers in Cellular Neuroscience, 2021
The hippocampal formation consists of the Ammon’s horn (cornu Ammonis with its regions CA1-4), dentate gyrus, subiculum, and the entorhinal cortex.
Sarah Woelfle, Sarah Woelfle, Tobias M. Boeckers, Tobias M. Boeckers   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Delayed hippocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higher and longer-term expression of p63 in the ischemic hippocampus

Neural Regeneration Research, 2015
The tumor suppressor p63 is one of p53 family members and plays a vital role as a regulator of neuronal apoptosis in the development of the nervous system. However, the role of p63 in mature neuronal death has not been addressed yet.
Eun Joo Bae, Bai Hui Chen, Bing Chun Yan, Bich Na Shin, Jeong Hwi Cho, In Hye Kim, Ji Hyeon Ahn, Jae Chul Lee, Hyun-Jin Tae, Seongkweon Hong, Dong Won Kim, Jun Hwi Cho, Yun Lyul Lee, Moo-Ho Won, Joon Ha Park   +14 more
doaj   +1 more source