Results 101 to 110 of about 6,745,376 (244)

Immature, Semi-mature and Fully mature Dendritic Cells: Towards a DC-cancer cells interface that augments anticancer immunity

Frontiers in Immunology, 2013
Dendritic cells (DCs) are the sentinel antigen-presenting cells of the immune system; such that their productive interface with the dying cancer cells is crucial for proper communication of the non-self status of cancer cells to the adaptive immune ...
Aleksandra Maria Dudek, Shaun eMartin, Abhishek Dinkarnath Garg, Patrizia eAgostinis   +3 more
doaj   +1 more source

Immunogenic cell death and immunogenic surrender- related but distinct mechanisms of immune surveillance

, 2022
10.1038/s41419-021-04178-6original data for figures 1 and 2 of the review: Immunogenic cell death and immunogenic surrender- related but distinct mechanisms of immune surveillance.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
crippa, M (via Mendeley Data)
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Frontier knowledge and future directions of programmed cell death in clear cell renal cell carcinoma

Cell Death Discovery
Clear cell renal cell carcinoma (ccRCC) is one of the most common renal malignancies of the urinary system. Patient outcomes are relatively poor due to the lack of early diagnostic markers and resistance to existing treatment options.
Cao Fei, Xu Zhen, Zhang Shiqiang, Pang Jun   +3 more
doaj   +1 more source

RIPK1‐mediated immunogenic cell death promotes anti‐tumour immunity against soft‐tissue sarcoma

EMBO Molecular Medicine, 2020
Drugs that mobilise the immune system against cancer are dramatically improving care for many people. Dying cancer cells play an active role in inducing anti‐tumour immunity but not every form of death can elicit an immune response.
Henry G Smith, Kunzah Jamal, Jasbani HS Dayal, Tencho Tenev, Joan Kyula‐Currie, Naomi Guppy, Patrycja Gazinska, Victoria Roulstone, Gianmaria Liccardi, Emma Davies, Ioannis Roxanis, Alan A Melcher, Andrew J Hayes, Gareth J Inman, Kevin J Harrington, Pascal Meier   +15 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Biochemical and cellular mechanisms of immunogenic cell death [PDF]

The Ukrainian Biochemical Journal
Immunogenic cell death (ICD) is a mode of programmed cell death that leads to the activation of anticancer immune response and determines the long-term success of anticancer therapies.
M. Klishch, N. Skorokhyd, R. Panchuk, R. Stoika   +3 more
doaj   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth [PDF]

, 2009
Background: Anti-cancer chemotherapy can be simultaneously lymphodepleting and immunostimulatory. Pre-clinical models clearly demonstrate that chemotherapy can synergize with immunotherapy, raising the question how the immune system can be mobilized to ...
Amy Prosser, Robinson, B.W.S., Currie, A.J., Scalzo, A.A., Joanne Salmons, Robbert G van der Most, Mark J Smyth, Bruce W S Robinson, Salmons, J., Lake, R.A., Smyth Mark J., Andrew J Currie, Amanda L Cleaver, Prosser, Amy, van der Most, R.G., Degli-Esposti, M.A., Salmons, Joanne, Lake, Richard A., Prosser, A., Prosser Amy, Nowak, A.K., Currie, Andrew J., van der Most Robbert G., Smyth, M.J., Robinson Bruce W. S., Lake Richard A., Degli-Esposti, Mariapia A., Scalzo Anthony A., Currie Andrew J., Nowak, Anna K., Sathish Mahendran, Cleaver, Amanda L., Richard A Lake, Nowak Anna K., van der Most, Robbert G., Larma, I., Mahendran, S., Anna K Nowak, Degli-Esposti Mariapia A., Anthony A Scalzo, Cleaver, A.L., Robinson, Bruce W.S., Larma, Irma, Irma Larma, Cleaver Amanda L., Smyth, Mark J., Larma Irma, Mehendran, Sathish, Scalzo, Anthony A., Salmons Joanne, Mahendran Sathish, Mariapia A Degli-Esposti   +51 more
core   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source