Results 81 to 90 of about 6,745,376 (244)

Cellular stress responses: cell survival and cell death [PDF]

, 2010
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells.
Afshin Samali, Hori, Osamu, Gorman, Adrienne M., 26106, Fulda, Simone, 26105, Samali, Afshin, 26107, 60303947, 233, Simone Fulda, Osamu Hori, Adrienne M. Gorman   +12 more
core   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Consensus guidelines for the detection of immunogenic cell death [PDF]

OncoImmunology, 2014
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named "immunogenic cell death" (ICD).
Oliver Kepp, Norma Bloy, Laura Bracci, Karine Breckpot, David Brough, Aitziber Buqu, Maria Castro, G., Mara Cirone, Maria Colombo, I., Isabelle Cremer, Sandra Demaria, Laura Senovilla, Luciana Dini, Aristides Eliopoulos, G., Alberto Faggioni, Silvia Formenti, C., Jitka Fukov, Lucia Gabriele, Udo Gaipl, S., Jrme Galon, Abhishek Garg, Franois Ghiringhelli, Ilio Vitale, Nathalia Giese, A., Zong Sheng Guo, Akseli Hemminki, Martin Herrmann, James Hodge, W., Stefan Holdenrieder, Jamie Honeychurch, Hong-min Hu, Xing Huang, Tim Illidge, M., Erika Vacchelli, Koji Konoa, Mladen Korbelik, Dmitri Krysko, V., Sherene Loi, Pedro Lowenstein, R., Enrico Lugli, Yuting Ma, Frank Madeo, Angelo Manfredi, A., Isabelle Martins, Sandy Adjemian, Domenico Mavilio, Laurie Menger, Merendino, Nicolo', Michael Michaud, Gregoire Mignot, Karen Mossman, L., Gabriele Multhoff, Rudolf Oehler, Fabio Palombo, Theocharis Panaretakis, Patrizia Agostini, Jonathan Pol, Enrico Proietti, Jean-ehrland Ricci, Chiara Riganti, Patrizia Rovere-querini, Anna Rubartelli, Antonella Sistigu, Mark Smyth, J., Juergen Sonnemann, Radek Spisek, Lionel Apetoh, John Stagg, Abdul Qader Sukkurwala, Eric Tartour, Andrew Thorburn, Stephen Thorne, H., Peter Vandenabeele, Francesca Velotti, Samuel Workenhe, T., Haining Yang, Wei-xing Zong, Fernando Aranda, Laurence Zitvogel, Guido Kroemer Lorenzo Galluzzi, Kepp, O., Senovilla, L., Velotti, Francesca Romana, Galluzzi, L., Vincenzo Barnaba   +84 more
openaire   +8 more sources

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Induction of immunogenic cell death of tumors by newly synthesized heterocyclic quinone derivative. [PDF]

PLoS ONE, 2017
Many cancer types are serious diseases causing mortality, and new therapeutics with improved efficacy and safety are required. Immuno-(cell)-therapy is considered as one of the promising therapeutic strategies for curing intractable cancer. In this study,
Keum-Joo Son, Ki Ryung Choi, Chung-Kyu Ryu, Seog Jae Lee, Ho Jeong Kim, Hyunah Lee   +5 more
doaj   +1 more source

Immunogenic cell death (ICD) enhancers—Drugs that enhance the perception of ICD by dendritic cells

, 2023
International audienceSummary The search for immunostimulatory drugs applicable to cancer immunotherapy may profit from target‐agnostic methods in which agents are screened for their functional impact on immune cells cultured in vitro without any ...
Kepp, Oliver, Liwei Zhao, Peng Liu, Zhao, Liwei, Zitvogel, Laurence, Laurence Zitvogel, Liu, Peng, Oliver Kepp, Guido Kroemer, Kroemer, Guido   +9 more
core   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source