Results 71 to 80 of about 6,745,376 (244)

eIF2α phosphorylation is pathognomonic for immunogenic cell death [PDF]

Cell Death & Differentiation, 2018
The phosphorylation of eIF2α is essential for the endoplasmic reticulum (ER) stress response, the formation of stress granules, as well as macroautophagy. Several successful anticancer chemotherapeutics have the property to induce immunogenic cell death (ICD), thereby causing anticancer immune responses.
Bezu L, Sauvat A, Humeau J, Gomes-da-Silva LC, Iribarren K, Forveille S, Garcia P, Zhao L, Liu P, Zitvogel L, Senovilla L, Kepp O, Kroemer G.   +12 more
openaire   +2 more sources

Cellular cytotoxicity is a form of immunogenic cell death [PDF]

Journal for ImmunoTherapy of Cancer, 2020
Background The immune response to cancer is often conceptualized with the cancer immunity cycle. An essential step in this interpretation is that antigens released by dying tumors are presented by dendritic cells to naive or memory T cells in the tumor-draining lymph nodes.
Luna Minute, Alvaro Teijeira, Alfonso R Sanchez-Paulete, Maria C Ochoa, Maite Alvarez, Itziar Otano, Iñaki Etxeberrria, Elixabet Bolaños, Arantza Azpilikueta, Saray Garasa, Noelia Casares, Jose Luis Perez Gracia, Maria E Rodriguez-Ruiz, Pedro Berraondo, Ignacio Melero   +14 more
openaire   +4 more sources

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

, 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives.
Gross, Atan, Vucic, Domagoj, Piacentini, Mauro, Altucci, Lucia, Adam, Dieter, Tsujimoto, Yoshihide, Wang, Ying, Elrod, John W, Pagano, Michele, Wells, James A, Garrido, Carmen, Thorburn, Andrew, De Maria, Ruggero, Lipton, Stuart A, Lockshin, Richard A, Rodrigues, Cecilia M P, Nagata, Shigekazu, Pasparakis, Manolis, Overholtzer, Michael, Blomgren, Klas, Boya, Patricia, Szabadkai, Gyorgy, Villunger, Andreas, Green, Douglas R, Andrews, David W, Gottlieb, Eyal, Lemasters, John J, Vitale, Ilio, Conrad, Marcus, Golstein, Pierre, Hardwick, J Marie, Sayan, Emre, Arama, Eli, Zakeri, Zahra, Muñoz-Pinedo, Cristina, Klionsky, Daniel J, Amelio, Ivano, Yuan, Junying, Bernassola, Francesca, Bianchi, Katiuscia, Silke, John, Fimia, Gian Maria, Dawson, Ted M, Kepp, Oliver, Strasser, Andreas, Knight, Richard A, Tang, Daolin, Vousden, Karen H, Karin, Michael, Nuñez, Gabriel, Harris, Isaac S, Zitvogel, Laurence, Lee, Sam W, Hengartner, Michael O, Linkermann, Andreas, Mehlen, Patrick, Wood, Will, MacFarlane, Marion, Penninger, Josef M, Panaretakis, Theocharis, García-Sáez, Ana J, Kumar, Sharad, Juin, Philippe P, Pereira, David M, Scorrano, Luca, DeBerardinis, Ralph J, Garg, Abhishek D, Kaiser, William J, Prehn, Jochen H M, Kroemer, Guido, Di Daniele, Nicola, D'Angiolella, Vincenzo, Hetz, Claudio, Dynlacht, Brian D, Oberst, Andrew, Barlev, Nickolai A, Antonov, Alexey V, Fulda, Simone, Aaronson, Stuart A, Bazan, Nicolas G, Chipuk, Jerry E, De Laurenzi, Vincenzo, Vander Heiden, Matthew G, El-Deiry, Wafik S, Virgin, Herbert W, Cubillos-Ruiz, Juan R, Malewicz, Michal, Rudel, Thomas, Melino, Gerry, Czabotar, Peter E, Luedde, Tom, Marine, Jean-Christophe, Blagosklonny, Mikhail V, Chan, Francis K-M, Tait, Stephen W G, Jost, Philipp J, Levine, Beth, Kaufmann, Thomas, Alnemri, Emad S, Dawson, Valina L, Pinton, Paolo, Kitsis, Richard N, Ryan, Kevin M, Sistigu, Antonella, Hajnoczky, Gyorgy, Baehrecke, Eric H, Cheng, Emily H, Dixon, Scott J, Carmona-Gutierrez, Didac, Ichijo, Hidenori, López-Otín, Carlos, Rizzuto, Rosario, Kimchi, Adi, Joseph, Bertrand, Medema, Jan Paul, Duckett, Colin S, Tavernarakis, Nektarios, Cecconi, Francesco, Pervaiz, Shazib, Greene, Lloyd A, Stockwell, Brent R, Miao, Edward A, Moll, Ute M, Abrams, John M, Vanden Berghe, Tom, Wagner, Erwin F, Lowe, Scott W, Ciechanover, Aaron, Melino, Sonia, Vandenabeele, Peter, Agostinis, Patrizia, Molkentin, Jeffery D, Brenner, Catherine, Martin, Seamus J, Peter, Marcus E, Cohen, Gerald M, Gronemeyer, Hinrich, Madeo, Frank, Gavathiotis, Evripidis, Dixit, Vishva M, Galluzzi, Lorenzo, Puthalakath, Hamsa, Jäättelä, Marja, Rehm, Markus, Campanella, Michelangelo, Shao, Feng, Wallach, David, Meier, Pascal, Borner, Christoph, Candi, Eleonora, Walczak, Henning, Cidlowski, John A, Chandel, Navdeep S, Deshmukh, Mohanish, Martinou, Jean-Claude, Rabinovich, Gabriel A, Lugli, Enrico, Malorni, Walter, Di Virgilio, Francesco, Rubinsztein, David C, Zhivotovsky, Boris, Oren, Moshe, Annicchiarico-Petruzzelli, Margherita, Shi, Yufang, Simon, Hans-Uwe, Turk, Boris, Manic, Gwenola, Bertrand, Mathieu J M, Debatin, Klaus-Michael   +168 more
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Immunogenic cell death [PDF]

, 2018
According to the danger model, the immune system is activated by endogenous molecules known as danger-associated molecular patterns (DAMP) that are externalized from the interior of a dying cell to the cell surface or released into the extracellular ...
Šímová, Michaela
core  

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Solid-state electron-mediated z-scheme heterostructured semiconductor nanomaterials induce dual programmed cell death for melanoma therapy

Journal of Nanobiotechnology
The programmed cell death (PCD) pathway removes functionally insignificant, infection-prone, or potentially tumorigenic cells, underscoring its important role in maintaining the stability of the internal environment and warding off cancer and a host of ...
Yiping Ren, Yun Wang, Cheng Chen, Xiang Yan, Minghao Chao, Yuting Li, Dehong Yu, Yuqi Huang, Xiaoyang Hou, Fenglei Gao, Guan Jiang, Ming Guan   +11 more
doaj   +1 more source

Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation

, 2010
Immunogenic profile of certain cancer cell death mechanisms has been transmuted by research published over a period of last few years and this change has been so drastic that a new (sub)class of apoptotic cancer cell death, redefined as ‘immunogenic ...
Golab, Jakub, Golab, J, Vandenabeele, Peter, Garg, Abhishek, Agostinis, Patrizia, Nowis, D, Garg, AD, Krysko, Dmitri, Agostinis, P, Nowis, Dominika, Krysko, Dmitri V.   +10 more
core   +1 more source