Results 71 to 80 of about 7,237,819 (287)

eIF2α phosphorylation is pathognomonic for immunogenic cell death [PDF]

Cell Death & Differentiation, 2018
The phosphorylation of eIF2α is essential for the endoplasmic reticulum (ER) stress response, the formation of stress granules, as well as macroautophagy. Several successful anticancer chemotherapeutics have the property to induce immunogenic cell death (ICD), thereby causing anticancer immune responses.
Bezu L, Sauvat A, Humeau J, Gomes-da-Silva LC, Iribarren K, Forveille S, Garcia P, Zhao L, Liu P, Zitvogel L, Senovilla L, Kepp O, Kroemer G.   +12 more
openaire   +2 more sources

Cellular cytotoxicity is a form of immunogenic cell death [PDF]

Journal for ImmunoTherapy of Cancer, 2020
Background The immune response to cancer is often conceptualized with the cancer immunity cycle. An essential step in this interpretation is that antigens released by dying tumors are presented by dendritic cells to naive or memory T cells in the tumor-draining lymph nodes.
Luna Minute, Alvaro Teijeira, Alfonso R Sanchez-Paulete, Maria C Ochoa, Maite Alvarez, Itziar Otano, Iñaki Etxeberrria, Elixabet Bolaños, Arantza Azpilikueta, Saray Garasa, Noelia Casares, Jose Luis Perez Gracia, Maria E Rodriguez-Ruiz, Pedro Berraondo, Ignacio Melero   +14 more
openaire   +4 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Lenvatinib Induces Immunogenic Cell Death and Triggers Toll-Like Receptor-3/4 Ligands in Hepatocellular Carcinoma

, 2023
Cheng Zhou,1,* Zhang-Fu Yang,1,* Bao-Ye Sun,1,* Yong Yi,1 Zheng Wang,1 Jian Zhou,1 Jia Fan,1 Wei Gan,1 Ning Ren,1,2 Shuang-Jian Qiu1 1Department of Liver Surgery and Transplantation & Key Laboratory of Carcinogenesis and Cancer Invasion ...
Yi Y, Yang ZF, Fan J, Zhou C, Ren N, Wang Z, Gan W, Sun BY, Zhou J, Qiu SJ   +9 more
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Solid-state electron-mediated z-scheme heterostructured semiconductor nanomaterials induce dual programmed cell death for melanoma therapy

Journal of Nanobiotechnology
The programmed cell death (PCD) pathway removes functionally insignificant, infection-prone, or potentially tumorigenic cells, underscoring its important role in maintaining the stability of the internal environment and warding off cancer and a host of ...
Yiping Ren, Yun Wang, Cheng Chen, Xiang Yan, Minghao Chao, Yuting Li, Dehong Yu, Yuqi Huang, Xiaoyang Hou, Fenglei Gao, Guan Jiang, Ming Guan   +11 more
doaj   +1 more source

Consensus guidelines for the detection of immunogenic cell death [PDF]

OncoImmunology, 2014
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named "immunogenic cell death" (ICD).
Oliver Kepp, Norma Bloy, Laura Bracci, Karine Breckpot, David Brough, Aitziber Buqu, Maria Castro, G., Mara Cirone, Maria Colombo, I., Isabelle Cremer, Sandra Demaria, Laura Senovilla, Luciana Dini, Aristides Eliopoulos, G., Alberto Faggioni, Silvia Formenti, C., Jitka Fukov, Lucia Gabriele, Udo Gaipl, S., Jrme Galon, Abhishek Garg, Franois Ghiringhelli, Ilio Vitale, Nathalia Giese, A., Zong Sheng Guo, Akseli Hemminki, Martin Herrmann, James Hodge, W., Stefan Holdenrieder, Jamie Honeychurch, Hong-min Hu, Xing Huang, Tim Illidge, M., Erika Vacchelli, Koji Konoa, Mladen Korbelik, Dmitri Krysko, V., Sherene Loi, Pedro Lowenstein, R., Enrico Lugli, Yuting Ma, Frank Madeo, Angelo Manfredi, A., Isabelle Martins, Sandy Adjemian, Domenico Mavilio, Laurie Menger, Merendino, Nicolo', Michael Michaud, Gregoire Mignot, Karen Mossman, L., Gabriele Multhoff, Rudolf Oehler, Fabio Palombo, Theocharis Panaretakis, Patrizia Agostini, Jonathan Pol, Enrico Proietti, Jean-ehrland Ricci, Chiara Riganti, Patrizia Rovere-querini, Anna Rubartelli, Antonella Sistigu, Mark Smyth, J., Juergen Sonnemann, Radek Spisek, Lionel Apetoh, John Stagg, Abdul Qader Sukkurwala, Eric Tartour, Andrew Thorburn, Stephen Thorne, H., Peter Vandenabeele, Francesca Velotti, Samuel Workenhe, T., Haining Yang, Wei-xing Zong, Fernando Aranda, Laurence Zitvogel, Guido Kroemer Lorenzo Galluzzi, Kepp, O., Senovilla, L., Velotti, Francesca Romana, Galluzzi, L., Vincenzo Barnaba   +84 more
openaire   +8 more sources