Results 51 to 60 of about 6,745,376 (244)
Molecular characteristics of immunogenic cancer cell death [PDF]
Cell Death & Differentiation, 2007 Apoptotic cell death is initiated by a morphologically homogenous entity that was considered to be non-immunogenic and non-inflammatory in nature. However, recent advances suggest that apoptosis, under certain circumstances, can be immunogenic. In particular, some characteristics of the plasma membrane, acquired at preapoptotic stage, can cause immune ...
A, Tesniere +6 more
openaire +2 more sources
, 2023 Cheng Zhou,1,* Zhang-Fu Yang,1,* Bao-Ye Sun,1,* Yong Yi,1 Zheng Wang,1 Jian Zhou,1 Jia Fan,1 Wei Gan,1 Ning Ren,1,2 Shuang-Jian Qiu1 1Department of Liver Surgery and Transplantation & Key Laboratory of Carcinogenesis and Cancer Invasion ...
Yi Y +9 more
core
Patritumab deruxtecan induces immunogenic cell death
OncoImmunologyAntibody-drug conjugates (ADCs) enable targeted delivery of cytotoxic payload to cancer cells. Here, we characterized the mode of action of the ADC patritumab deruxtecan, which is a monoclonal antibody specific for Erb-B2 Receptor Tyrosine Kinase 3 ...
Sabrina Forveille +9 more
doaj +1 more source
Mathematical Models of Death Signaling Networks
Entropy, 2022 This review provides an overview of the progress made by computational and systems biologists in characterizing different cell death regulatory mechanisms that constitute the cell death network.
Madhumita Srinivasan +2 more
doaj +1 more source
Immunogenic apoptotic cell death and anticancer immunity
, 2016 For many years it has been thought that apoptotic cells rapidly cleared by phagocytic cells do not trigger an immune response but rather have anti-inflammatory properties. However, accumulating experimental data indicate that certain anticancer therapies
Claus Bachert +14 more
core +1 more source
Immunogenic Cell Death: An Emerging Target in Gastrointestinal Cancers
, 2022 Immunogenic cell death (ICD) is a regulated form of cell death that induces the activation of both innate and adaptive immune responses through the release of damage-associated molecular patterns (DAMPs) and their subsequent recognition by pattern ...
Carbone, Carmine +11 more
core +1 more source
Screening for immunogenic cell death [PDF]
Science-Business eXchange, 2012 French researchers have used a fluorescence-based screening platform to identify small molecules that induced immunogenic cell death in mouse tumors. Next, the group plans to test the best hits in a Phase I/II trial to treat locally invasive head and neck cancers in combination with chemotherapy.
openaire +1 more source
Dying in self-defence : a comparative overview of immunogenic cell death signalling in animals and plants [PDF]
, 2022 Host organisms utilise a range of genetically encoded cell death programmes in response to pathogen challenge. Host cell death can restrict pathogen proliferation by depleting their replicative niche and at the same time dying cells can alert ...
Kashkar, Hamid +3 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Immunogenic Cell Death Role in Urothelial Cancer Therapy
Current Oncology, 2022 Purpose: Bladder cancer is the 13th most common cause of cancer death with the highest lifetime cost for treatment of all cancers. This scoping review clarifies the available evidence on the role of a novel therapeutic approach called immunogenic cell ...
Reza Yadollahvandmiandoab +4 more
doaj +1 more source