Results 51 to 60 of about 7,237,819 (287)

Immunogenic cell death: The cornerstone of oncolytic viro-immunotherapy

Frontiers in Immunology, 2023
According to the World Health Organization, cancer is one of the leading global health concerns, causing nearly 10 million deaths in 2020. While classical chemotherapeutics produce strong cytotoxicity on cancer cells, they carry limitations of drug ...
Lalitha Palanivelu, Ching-Hsuan Liu, Ching-Hsuan Liu, Ching-Hsuan Liu, Liang-Tzung Lin, Liang-Tzung Lin   +5 more
doaj   +1 more source

Immunogenic cell death‐inducing small molecule inhibitors: Potential for immunotherapy of cancer

, 2022
Small molecule inhibitors (SMIs) of key signalling pathways are known to induce multiple types of regulated cell death, including immunogenic cell death (ICD).
Zhi Zhu, Zong Sheng Guo, Hongqi Chen, Pawel Kalinski   +3 more
core   +1 more source

Molecular characteristics of immunogenic cancer cell death [PDF]

Cell Death & Differentiation, 2007
Apoptotic cell death is initiated by a morphologically homogenous entity that was considered to be non-immunogenic and non-inflammatory in nature. However, recent advances suggest that apoptosis, under certain circumstances, can be immunogenic. In particular, some characteristics of the plasma membrane, acquired at preapoptotic stage, can cause immune ...
A, Tesniere, T, Panaretakis, O, Kepp, L, Apetoh, F, Ghiringhelli, L, Zitvogel, G, Kroemer   +6 more
openaire   +2 more sources

Nanocarrier-Mediated Immunogenic Cell Death for Melanoma Treatment

International Journal of Nanomedicine, 2023
Jiandong Wang,1– 3,* Jinyuan Ma,1,4,* Zongguang Tai,1,4,* Lisha Li,1,4 Tingrui Zhang,1,4 Tingting Cheng,1– 3 Junxia Yu,1– 3 Quangang Zhu,1,4 Leilei Bao,2 Zhongjian Chen1,4 1Shanghai Skin Disease Hospital, School of Medicine, Tongji University,
Wang J, Ma J, Tai Z, Li L, Zhang T, Cheng T, Yu J, Zhu Q, Bao L, Chen Z   +9 more
doaj  

Trial watch: chemotherapy-induced immunogenic cell death in oncology

OncoImmunology, 2023
Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated cell death that activates, rather than suppresses, innate and adaptive immune responses. Such responses culminate into T cell-driven immunity against antigens derived
Jenny Sprooten, Raquel S. Laureano, Isaure Vanmeerbeek, Jannes Govaerts, Stefan Naulaerts, Daniel M. Borras, Lisa Kinget, Jitka Fucíková, Radek Špíšek, Lenka Palová Jelínková, Oliver Kepp, Guido Kroemer, Dmitri V. Krysko, An Coosemans, Rianne D.W. Vaes, Dirk De Ruysscher, Steven De Vleeschouwer, Els Wauters, Evelien Smits, Sabine Tejpar, Benoit Beuselinck, Sigrid Hatse, Hans Wildiers, Paul M. Clement, Peter Vandenabeele, Laurence Zitvogel, Abhishek D. Garg   +26 more
doaj   +1 more source

Patritumab deruxtecan induces immunogenic cell death

OncoImmunology
Antibody-drug conjugates (ADCs) enable targeted delivery of cytotoxic payload to cancer cells. Here, we characterized the mode of action of the ADC patritumab deruxtecan, which is a monoclonal antibody specific for Erb-B2 Receptor Tyrosine Kinase 3 ...
Sabrina Forveille, Liwei Zhao, Allan Sauvat, Giulia Cerrato, Marion Leduc, Flora Doffe, Yuhong Pan, Peng Liu, Guido Kroemer, Oliver Kepp   +9 more
doaj   +1 more source

Screening for immunogenic cell death [PDF]

Science-Business eXchange, 2012
French researchers have used a fluorescence-based screening platform to identify small molecules that induced immunogenic cell death in mouse tumors. Next, the group plans to test the best hits in a Phase I/II trial to treat locally invasive head and neck cancers in combination with chemotherapy.
openaire   +1 more source

Mathematical Models of Death Signaling Networks

Entropy, 2022
This review provides an overview of the progress made by computational and systems biologists in characterizing different cell death regulatory mechanisms that constitute the cell death network.
Madhumita Srinivasan, Robert Clarke, Pavel Kraikivski   +2 more
doaj   +1 more source

Immunogenic apoptotic cell death and anticancer immunity

, 2016
For many years it has been thought that apoptotic cells rapidly cleared by phagocytic cells do not trigger an immune response but rather have anti-inflammatory properties. However, accumulating experimental data indicate that certain anticancer therapies
Claus Bachert, Bachert, Claus, Olga Krysko, Vandecasteele, Katrien, Krysko, O, Bachert, C,, Vandenabeele, P, Vandecasteele, K, Krysko, DV, Katrien Vandecasteele, Krysko, Olga, Dmitri V. Krysko, Vandenabeele, Peter, Krysko, Dmitri, Peter Vandenabeele   +14 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source