Results 41 to 50 of about 7,237,819 (287)

Lysosomal lipid peroxidation mediates immunogenic cell death

The Journal of Clinical Investigation, 2023
Cancer cells rely on lysosome-dependent degradation to recycle nutrients that serve their energetic and biosynthetic needs. Despite great interest in repurposing the antimalarial hydroxychloroquine as a lysosomal inhibitor in clinical oncology trials ...
Pravin Phadatare, Jayanta Debnath
doaj   +1 more source

KRAS-elicited PDIA6 blocks PERK-dependent immunogenic cell death in pancreatic carcinoma. [PDF]

Oncoimmunology
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) remains largely refractory to immune checkpoint blockade. Wang et al. identified PDIA6 as a KRAS-driven suppressor of PERK-dependent immunogenic cell death, fostering immune exclusion.
Zhao L, Liu P, Kroemer G, Kepp O.
europepmc   +2 more sources

Viral strategies for the evasion of immunogenic cell death [PDF]

Journal of Internal Medicine, 2010
Abstract.  Galluzzi L, Kepp O, Morselli E, Vitale I, Senovilla L, Pinti M, Zitvogel L, Kroemer G (INSERM, U848; Institut Gustave Roussy; and Université Paris Sud‐XI, Paris, France; Università degli studi di Modena e Reggio Emilia, Modena, Italy; INSERM, U805, Paris, France). Viral strategies for the evasion of immunogenic cell death (Symposium).
GALLUZZI, Lorenzo, Kepp O, MORSELLI, EUGENIA, Vitale I, Senovilla L, PINTI, Marcello, Zitvogel L, Kroemer G.   +7 more
openaire   +3 more sources

Non-thermal plasma induces immunogenic cell death in vivo in murine CT26 colorectal tumors

OncoImmunology, 2018
Immunogenic cell death is characterized by the emission of danger signals that facilitate activation of an adaptive immune response against dead-cell antigens.
Abraham G. Lin, Bo Xiang, Dante J. Merlino, Trevor R. Baybutt, Joya Sahu, Alexander Fridman, Adam E. Snook, Vandana Miller   +7 more
doaj   +1 more source

Immunogenic effects of chemotherapy-induced tumor cell death

Genes and Diseases, 2018
Emerging evidence suggests that the clinical success of conventional chemotherapy is not solely attributed to tumor cell toxicity, but also results from the restoration of immunosurveillance, which has been largely neglected in the past preclinical and ...
Yi-Jun Wang, Rochelle Fletcher, Jian Yu, Lin Zhang   +3 more
doaj   +1 more source

Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer

, 2020
Oncolytic viruses have the potential to induce immunogenic cell death (ICD) that may provoke potent and long-lasting anti-cancer immunity. Here we aimed to characterize the ICD-inducing ability of wild-type Adenovirus (Ad), Semliki Forest virus (SFV) and
Jin, Chuan, Martikainen, Miika,, Ramachandran, Mohanraj, Ramachandran, Mohanraj,, Quijano-Rubio, Clara,, Jin, Chuan,, Yu, Di, Ma, Jing, Quijano-Rubio, Clara, Ma, Jing,, Essand, Magnus, Martikainen, Miika, Yu, Di,, Essand, Magnus,   +13 more
core   +1 more source

The importance of immunogenic cell death for modern tumor immunotherapy [PDF]

, 2022
Immunogenic cell death is characterized by the release of molecules with damage-associated molecular patterns which can subsequently activate immune system. Only specific types of cell death can release these molecules. Classification of immunogenic cell
Kubešová, Kateřina
core  

Laser nanobubbles induce immunogenic cell death in breast cancer [PDF]

, 2021
Recent advances in immunotherapy have highlighted a need for therapeutics that initiate immunogenic cell death in tumors to stimulate the body's immune response to cancer.
Milner, Thomas E, Feng, Xu, Tunnell, James W, Baker, Aaron B, Suggs, Laura J, Widman, Jessica A, Katta, Nitesh, Betancourt, Tania, Takematsu, Eri, Nguyen, Hieu TM, Torres-Hurtado, Susana A, Nitesh Katta, Laura J. Suggs, Hieu T. M. Nguyen, Eri Takematsu, Susana A. Torres-Hurtado, Jessica A. Widman, Xu Feng, Tania Betancourt, Aaron B. Baker, Thomas E. Milner, James W. Tunnell   +21 more
core   +1 more source

The Concept of Immunogenic Cell Death in Antitumor Immunity [PDF]

Klinicka onkologie, 2015
Cancer cell death can be immunogenic or nonimmunogenic depending on the initiating stimulus. The immunogenic characteristics of immunogenic cell death are mainly mediated by damage-associated molecular patterns represented by preapoptotic exposure of calreticulin and heat shock proteins (HSP70 and HSP90) from endoplasmic reticulum at the cell surface ...
J, Fučíková, J, Bartůňková, R, Špíšek   +2 more
openaire   +2 more sources

The anticancer peptide RT53 induces immunogenic cell death. [PDF]

PLoS ONE, 2018
In recent years, immunogenic cell death (ICD) has emerged as a revolutionary concept in the development of novel anticancer therapies. This particular form of cell death is able, through the spatiotemporally defined emission of danger signals by the ...
Ewa Pasquereau-Kotula, Justine Habault, Guido Kroemer, Jean-Luc Poyet   +3 more
doaj   +1 more source