Results 21 to 30 of about 7,237,819 (287)

The inducers of immunogenic cell death for tumor immunotherapy

Tumori Journal, 2018
Immunotherapy is a promising treatment modality that acts by selectively harnessing the host immune defenses against cancer. An effective immune response is often needed to eliminate tumors following treatment which can trigger the immunogenicity of ...
Xiuying Li
core   +3 more sources

RIPK1‐mediated immunogenic cell death promotes anti‐tumour immunity against soft‐tissue sarcoma

EMBO Molecular Medicine, 2020
Drugs that mobilise the immune system against cancer are dramatically improving care for many people. Dying cancer cells play an active role in inducing anti‐tumour immunity but not every form of death can elicit an immune response.
Henry G Smith, Kunzah Jamal, Jasbani HS Dayal, Tencho Tenev, Joan Kyula‐Currie, Naomi Guppy, Patrycja Gazinska, Victoria Roulstone, Gianmaria Liccardi, Emma Davies, Ioannis Roxanis, Alan A Melcher, Andrew J Hayes, Gareth J Inman, Kevin J Harrington, Pascal Meier   +15 more
doaj   +2 more sources

BQ-AurIPr: A Redox-Active Anticancer Au(I) Complex that Induces Immunogenic Cell Death in Non-Small Cell Lung Cancer [PDF]

, 2022
Immunogenic Cell Death (ICD) is a unique cell death mechanism that kills cancer cells while rejuvenating the anti-cancer immunosurveillance, thereby benefiting the clinical outcomes of various chemo-immunotherapeutic regimens.
Akhilesh , Kumar, Shashank P., Sancheti, B., Senthilkumar, Nitin T., Patil, Himanshu, Kumar, Ravindra D., Mule   +5 more
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Targeting immunogenic cell death in cancer [PDF]

Molecular Oncology, 2020
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic therapy, and radiotherapy. It involves the activation of the immune system against cancer in immunocompetent hosts.
Ahmed, Asma, Tait, Stephen W.G.
openaire   +3 more sources

Immunogenic and tolerogenic cell death [PDF]

Nature Reviews Immunology, 2009
The immune system is routinely exposed to dead cells during normal cell turnover, injury and infection. Mechanisms must exist to discriminate between different forms of cell death to correctly eliminate pathogens and promote healing while avoiding responses to self, which can result in autoimmunity.
Green, Douglas R., Ferguson, Thomas, Zitvogel, Laurence, Kroemer, Guido   +3 more
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Immunogenicity of necrotic cell death [PDF]

Cellular and Molecular Life Sciences, 2014
The mode of tumor cell death has significant effects on anti-tumor immunity. Although, previously it was thought that cell death is an inert effect, different investigators have clearly shown that dying tumors can attract, activate and mature professional antigen presenting cells and dendritic cells.
Jaba, Gamrekelashvili, Tim F, Greten, Firouzeh, Korangy   +2 more
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Immunogenic cell death in cancer immunotherapy

BMB Reports, 2023
Cancer immunotherapy has been acknowledged as a new paradigm for cancer treatment, with notable therapeutic effects on certain cancer types. Despite their significant potential, clinical studies over the past decade have revealed that cancer immunotherapy has low response rates in the majority of solid tumors.
Minji Choi, Jisoo Shin, Chae-Eun Lee, Joo-Yoon Chung, Minji Kim, Xiuwen Yan, Wen-Hao Yang, Jong-Ho Cha   +7 more
openaire   +2 more sources

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. [PDF]

, 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives.
Gross, Atan, Vucic, Domagoj, Piacentini, Mauro, Altucci, Lucia, Adam, Dieter, Tsujimoto, Yoshihide, Wang, Ying, Elrod, John W, Pagano, Michele, Wells, James A, Garrido, Carmen, Thorburn, Andrew, De Maria, Ruggero, Lipton, Stuart A, Lockshin, Richard A, Rodrigues, Cecilia M P, Nagata, Shigekazu, Pasparakis, Manolis, Overholtzer, Michael, Blomgren, Klas, Boya, Patricia, Szabadkai, Gyorgy, Villunger, Andreas, Green, Douglas R, Andrews, David W, Gottlieb, Eyal, Lemasters, John J, Vitale, Ilio, Conrad, Marcus, Golstein, Pierre, Hardwick, J Marie, Sayan, Emre, Arama, Eli, Zakeri, Zahra, Muñoz-Pinedo, Cristina, Klionsky, Daniel J, Amelio, Ivano, Yuan, Junying, Bernassola, Francesca, Bianchi, Katiuscia, Silke, John, Fimia, Gian Maria, Dawson, Ted M, Kepp, Oliver, Strasser, Andreas, Knight, Richard A, Tang, Daolin, Vousden, Karen H, Karin, Michael, Nuñez, Gabriel, Harris, Isaac S, Zitvogel, Laurence, Lee, Sam W, Hengartner, Michael O, Linkermann, Andreas, Mehlen, Patrick, Wood, Will, MacFarlane, Marion, Penninger, Josef M, Panaretakis, Theocharis, García-Sáez, Ana J, Kumar, Sharad, Juin, Philippe P, Pereira, David M, Scorrano, Luca, DeBerardinis, Ralph J, Garg, Abhishek D, Kaiser, William J, Prehn, Jochen H M, Kroemer, Guido, Di Daniele, Nicola, Hetz, Claudio, Dynlacht, Brian D, Oberst, Andrew, Barlev, Nickolai A, Antonov, Alexey V, Fulda, Simone, Aaronson, Stuart A, Bazan, Nicolas G, Chipuk, Jerry E, De Laurenzi, Vincenzo, Vander Heiden, Matthew G, El-Deiry, Wafik S, Virgin, Herbert W, Cubillos-Ruiz, Juan R, Malewicz, Michal, Rudel, Thomas, Melino, Gerry, Czabotar, Peter E, Luedde, Tom, Marine, Jean-Christophe, Blagosklonny, Mikhail V, Chan, Francis K-M, Tait, Stephen W G, Jost, Philipp J, Levine, Beth, Kaufmann, Thomas, Alnemri, Emad S, Dawson, Valina L, Pinton, Paolo, Kitsis, Richard N, Ryan, Kevin M, Sistigu, Antonella, Hajnoczky, Gyorgy, Baehrecke, Eric H, Cheng, Emily H, Dixon, Scott J, Carmona-Gutierrez, Didac, Ichijo, Hidenori, López-Otín, Carlos, Rizzuto, Rosario, Kimchi, Adi, Joseph, Bertrand, Medema, Jan Paul, Duckett, Colin S, Tavernarakis, Nektarios, Cecconi, Francesco, Pervaiz, Shazib, Greene, Lloyd A, Stockwell, Brent R, Miao, Edward A, Moll, Ute M, Abrams, John M, Vanden Berghe, Tom, Wagner, Erwin F, Lowe, Scott W, Ciechanover, Aaron, Melino, Sonia, Vandenabeele, Peter, Agostinis, Patrizia, Molkentin, Jeffery D, Brenner, Catherine, Martin, Seamus J, Peter, Marcus E, Cohen, Gerald M, Gronemeyer, Hinrich, Madeo, Frank, Gavathiotis, Evripidis, Dixit, Vishva M, Galluzzi, Lorenzo, Puthalakath, Hamsa, Jäättelä, Marja, Rehm, Markus, Campanella, Michelangelo, Shao, Feng, Wallach, David, Meier, Pascal, Borner, Christoph, Candi, Eleonora, Walczak, Henning, Cidlowski, John A, Chandel, Navdeep S, Deshmukh, Mohanish, Martinou, Jean-Claude, Rabinovich, Gabriel A, Lugli, Enrico, Malorni, Walter, Di Virgilio, Francesco, Rubinsztein, David C, Zhivotovsky, Boris, Oren, Moshe, Annicchiarico-Petruzzelli, Margherita, Shi, Yufang, Simon, Hans-Uwe, Turk, Boris, Manic, Gwenola, Bertrand, Mathieu J M, Debatin, Klaus-Michael, D'Angiolella, Vincenzo   +168 more
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Immunogenic Cell Death in Cancer Therapy

Acta Naturae, 2022
Apoptosis plays a crucial role in chemotherapy-induced cell death. The conventional theory holding that apoptosis needs to be immunologically silent has recently been revised, and the concept of immunogenic cell death (ICD) has been proposed. This review describes the main features of ICD induction. These ICD markers are important for the effectiveness
Olga S. Troitskaya, Diana D. Novak, Vladimir A. Richter, Olga A. Koval   +3 more
openaire   +2 more sources

Viral subversion of immunogenic cell death [PDF]

Cell Cycle, 2009
While physiological cell death is non-immunogenic, pathogen induced cell death can be immunogenic and hence stimulate an immune response against antigens that derive from dying cells and are presented by dendritic cells (DCs). The obligate immunogenic "eat-me" signal generated by dying cells consists in the exposure of calreticulin (CRT) at the cell ...
Oliver, Kepp, Laura, Senovilla, Lorenzo, Galluzzi, Theocharis, Panaretakis, Antoine, Tesniere, Frederic, Schlemmer, Frank, Madeo, Laurence, Zitvogel, Guido, Kroemer   +8 more
openaire   +2 more sources