Results 21 to 30 of about 131,333 (298)
Immunogenicity of necrotic cell death [PDF]
Cellular and Molecular Life Sciences, 2014 The mode of tumor cell death has significant effects on anti-tumor immunity. Although, previously it was thought that cell death is an inert effect, different investigators have clearly shown that dying tumors can attract, activate and mature professional antigen presenting cells and dendritic cells.
Jaba, Gamrekelashvili +2 more
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Immunogenic Cell Death in Cancer Therapy
Acta Naturae, 2022 Apoptosis plays a crucial role in chemotherapy-induced cell death. The conventional theory holding that apoptosis needs to be immunologically silent has recently been revised, and the concept of immunogenic cell death (ICD) has been proposed. This review describes the main features of ICD induction. These ICD markers are important for the effectiveness
Olga S. Troitskaya +3 more
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Viral subversion of immunogenic cell death [PDF]
Cell Cycle, 2009 While physiological cell death is non-immunogenic, pathogen induced cell death can be immunogenic and hence stimulate an immune response against antigens that derive from dying cells and are presented by dendritic cells (DCs). The obligate immunogenic "eat-me" signal generated by dying cells consists in the exposure of calreticulin (CRT) at the cell ...
Oliver, Kepp +8 more
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The International Journal of Developmental Biology, 2015 Currently, it is widely acknowledged that a proactive anticancer immunosurveillance mechanism takes part in the rejection of neoplastic lesions before they progress towards a benign or malignant tumour. However in cases of very aggressive neoplastic lesions consisting of cells with high mutational diversity, cancer cell variants might be formed that ...
Garg, Abhishek +3 more
openaire +4 more sources
The convergence of radiation and immunogenic cell death signaling pathways. [PDF]
, 2012 Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms ...
Barcellos-Hoff, Mary H +4 more
core +2 more sources
Immunogenic cell death in radiation therapy [PDF]
OncoImmunology, 2013 Radiation therapy has been extensively employed throughout the last century to treat individuals affected by multiple types of tumors, with a variable degree of success. Current estimates indicate indeed that at least 50% of cancer patients all confounded have been or will be exposed to ionizing irradiation, either as a standalone intervention or ...
Galluzzi, Lorenzo +2 more
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Tumor-intrinsic determinants of immunogenic cell death modalities
OncoImmunology, 2021 The immune system can recognize tumor cells to mount antigen-specific T cell response. Central to the establishment of T cell-mediated adaptive immunity are the inflammatory events that facilitate antigen presentation by stimulating the expression of MHC
Samuel T Workenhe +2 more
doaj +1 more source
DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown [PDF]
, 2011 Damage-associated molecular patterns (DAMPs) or cell death associated molecular patterns (CDAMPs) are a subset of endogenous intracellular molecules that are normally hidden within living cells but become either passively released by primary and ...
Agostinis, Patrizia +3 more
core +1 more source
Radiotherapy and Immunogenic Cell Death
Seminars in Radiation Oncology, 2015 Advances in understanding the mechanisms that underlie the interplay between radiation-invoked immune responses and tumor regression are underway. Emerging applications of local radiotherapy as an immunologic adjuvant have provided radiation oncologists with a method for converting malignant cells into endogenous anticancer vaccines.
Golden, Encouse B., Apetoh, Lionel
openaire +2 more sources
Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and dendritic cells [PDF]
, 2017 Docosahexaenoic acid (DHA), a ω-3 polyunsaturated fatty acid found in fish oil, is a multi-target agent and exerts anti-inflammatory and anticancer activities alone or in combination with chemotherapies.
D'Eliseo, Donatella +3 more
core +1 more source