Results 21 to 30 of about 83,436 (250)

Autophagy Modulates Immunogenic Cell Death in Cancer. [PDF]

Cancers (Basel)
Immunogenic cell death (ICD) is a subtype of regulated cell death characterized by the spatiotemporally coordinated emission of damage-associated molecular patterns (DAMPs), such as calreticulin (CALR), ATP, and high-mobility group box-1 (HMGB1), which collectively prime tumor-specific T-cell responses. Autophagy, a lysosome-dependent catabolic process,
Matsushita M, Moriwaki M.
europepmc   +4 more sources

Viral subversion of immunogenic cell death [PDF]

Cell Cycle, 2009
While physiological cell death is non-immunogenic, pathogen induced cell death can be immunogenic and hence stimulate an immune response against antigens that derive from dying cells and are presented by dendritic cells (DCs). The obligate immunogenic "eat-me" signal generated by dying cells consists in the exposure of calreticulin (CRT) at the cell ...
Oliver, Kepp, Laura, Senovilla, Lorenzo, Galluzzi, Theocharis, Panaretakis, Antoine, Tesniere, Frederic, Schlemmer, Frank, Madeo, Laurence, Zitvogel, Guido, Kroemer   +8 more
openaire   +2 more sources

IL6/IL10/TLR4 Govern Immunogenic Cell Death in Aortic Dissection [PDF]

Cardiovascular Therapeutics
Yukui Du, Dongqing Chang, Bofeng Yu, Li Zhang, Liang He, Fengxia Wang, Shaoyan Chang   +6 more
doaj   +2 more sources

Immunogenic cell death

The International Journal of Developmental Biology, 2015
Currently, it is widely acknowledged that a proactive anticancer immunosurveillance mechanism takes part in the rejection of neoplastic lesions before they progress towards a benign or malignant tumour. However in cases of very aggressive neoplastic lesions consisting of cells with high mutational diversity, cancer cell variants might be formed that ...
Garg, Abhishek, Dudek-Peric, Aleksandra M., Romano, Erminia, Agostinis, Patrizia   +3 more
openaire   +4 more sources

Immunogenic cell death in radiation therapy [PDF]

OncoImmunology, 2013
Radiation therapy has been extensively employed throughout the last century to treat individuals affected by multiple types of tumors, with a variable degree of success. Current estimates indicate indeed that at least 50% of cancer patients all confounded have been or will be exposed to ionizing irradiation, either as a standalone intervention or ...
Galluzzi, Lorenzo, Kepp, Oliver, Kroemer, Guido   +2 more
openaire   +2 more sources

Tumor-intrinsic determinants of immunogenic cell death modalities

OncoImmunology, 2021
The immune system can recognize tumor cells to mount antigen-specific T cell response. Central to the establishment of T cell-mediated adaptive immunity are the inflammatory events that facilitate antigen presentation by stimulating the expression of MHC
Samuel T Workenhe, Jonathan Pol, Guido Kroemer   +2 more
doaj   +1 more source

Immunogenic Cell Death in Hematological Malignancy Therapy

Advanced Science, 2023
Although the curative effect of hematological malignancies has been improved in recent years, relapse or drug resistance of hematological malignancies will eventually recur.
Zhaoyun Liu, Xintong Xu, Kaining Liu, Jingtian Zhang, Dan Ding, Rong Fu   +5 more
doaj   +1 more source

Radiotherapy and Immunogenic Cell Death

Seminars in Radiation Oncology, 2015
Advances in understanding the mechanisms that underlie the interplay between radiation-invoked immune responses and tumor regression are underway. Emerging applications of local radiotherapy as an immunologic adjuvant have provided radiation oncologists with a method for converting malignant cells into endogenous anticancer vaccines.
Golden, Encouse B., Apetoh, Lionel
openaire   +2 more sources

Combinatorial Strategies for the Induction of Immunogenic Cell Death [PDF]

Frontiers in Immunology, 2015
The term "immunogenic cell death" (ICD) is commonly employed to indicate a peculiar instance of regulated cell death (RCD) that engages the adaptive arm of the immune system. The inoculation of cancer cells undergoing ICD into immunocompetent animals elicits a specific immune response associated with the establishment of immunological memory.
Bezu, Lucillia, Gomes-De-Silva, Ligia C., Dewitte, Heleen, Breckpot, Karine, Fucikova, Jitka, Spisek, Radek, Galluzzi, Lorenzo, Kepp, Oliver, Kroemer, Guido   +8 more
openaire   +7 more sources

Inhibitory DAMPs in immunogenic cell death and its clinical implications

Cell Stress, 2021
Dying (or dead) cells are increasingly recognized to impose significant biological influence within their tissues of residence—exerting paracrine effects through proteins and metabolites that are expressed or secreted during cellular demise. For example,
Kazukuni Hayashi, Fotis Nikolos, Keith S. Chan   +2 more
doaj   +1 more source