Results 11 to 20 of about 7,237,819 (287)

Immunogenic Cell Death and Immunotherapy of Multiple Myeloma [PDF]

Frontiers in Cell and Developmental Biology, 2019
Over the past decades, immunotherapy has demonstrated a prominent clinical efficacy in a wide variety of human tumors. For many years, apoptosis has been considered a non-immunogenic or tolerogenic process whereas necrosis or necroptosis has long been ...
Alfonso Serrano-del Valle, Alberto Anel, Javier Naval, Isabel Marzo   +3 more
doaj   +5 more sources

Combinatorial Strategies for the Induction of Immunogenic Cell Death [PDF]

Frontiers in Immunology, 2015
International audienceThe term “immunogenic cell death” (ICD) is commonly employed to indicate a peculiar instance of regulated cell death (RCD) that engages the adaptive arm of the immune system.
Spisek, Radek, Kepp, Oliver, Dewitte, HeleenUGent0020053711288020008904169766219063730000-0002-1791-770X04E66146-F0EE-11E1-A9DE-61C894A0A6B4, Lorenzo Galluzzi, Galluzzi, Lorenzo, Dewitte, Heleen, Gomes-De-Silva, Ligia C., Lucillia Bezu, Oliver Kepp, Bezu, Lucillia, Fucikova, Jitka, Karine Breckpot, Radek Spisek, Heleen Dewitte, Ligia C. Gomes-de-Silva, Breckpot, Karine, Silva, Lígia C. Gomes da, Guido Kroemer, Kroemer, Guido, Gomes-da-Silva, Ligia C, Jitka Fucikova   +20 more
core   +10 more sources

Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib

Frontiers in Oncology, 2021
Cabozantinib (XL-184) is a multitarget tyrosine kinase inhibitor (TKI) targeting receptor tyrosine kinases (RTKs) involved in oncogenesis and angiogenesis.
Fabio Scirocchi, Chiara Napoletano, Angelica Pace, Hassan Rahimi Koshkaki, Alessandra Di Filippo, Ilaria Grazia Zizzari, Marianna Nuti, Aurelia Rughetti   +7 more
doaj   +4 more sources

Dying of Stress: Chemotherapy, Radiotherapy, and Small-Molecule Inhibitors in Immunogenic Cell Death and Immunogenic Modulation

Cells, 2022
Innovative strategies to re-establish the immune-mediated destruction of malignant cells is paramount to the success of anti-cancer therapy. Accumulating evidence suggests that radiotherapy and select chemotherapeutic drugs and small molecule inhibitors ...
Kellsye P. Fabian, Joshua T. Kowalczyk, Sandy T. Reynolds, James W. Hodge   +3 more
doaj   +2 more sources

Immunogenicity of cell death driven by immune effectors [PDF]

Journal for ImmunoTherapy of Cancer, 2020
Whether cell death caused by T lymphocytes and natural killer (NK) cells would be immunogenic per se has been a matter of intense debate. Two back-to-back papers from the Melero’s and Pardo’s groups have now resolved this conundrum, demonstrating that T ...
Lorenzo Galluzzi, Guido Kroemer, Giulia Petroni   +2 more
doaj   +3 more sources

Immunogenic Cell Death in Hematological Malignancy Therapy

Advanced Science, 2023
Although the curative effect of hematological malignancies has been improved in recent years, relapse or drug resistance of hematological malignancies will eventually recur.
Zhaoyun Liu, Xintong Xu, Kaining Liu, Jingtian Zhang, Dan Ding, Rong Fu   +5 more
doaj   +3 more sources

Induction of immunogenic cell death of tumors by newly synthesized heterocyclic quinone derivative. [PDF]

PLoS ONE, 2017
Many cancer types are serious diseases causing mortality, and new therapeutics with improved efficacy and safety are required. Immuno-(cell)-therapy is considered as one of the promising therapeutic strategies for curing intractable cancer. In this study,
Keum-Joo Son, Ki Ryung Choi, Chung-Kyu Ryu, Seog Jae Lee, Ho Jeong Kim, Hyunah Lee   +5 more
doaj   +3 more sources

Nanotechnology-Assisted Immunogenic Cell Death for Effective Cancer Immunotherapy

Vaccines, 2023
Tumor vaccines have been used to treat cancer. How to efficiently induce tumor-associated antigens (TAAs) secretion with host immune system activation is a key issue in achieving high antitumor immunity. Immunogenic cell death (ICD) is a process in which
Yichen Guo, Rong Ma, Mengzhe Zhang, Yongjian Cao, Zhenzhong Zhang, Weijing Yang   +5 more
doaj   +2 more sources

Inducers of immunogenic cancer cell death

Cytokine & Growth Factor Reviews, 2013
Recently, cytokine-based pro-tumourigenic signalling has been found to play a major role in the immune system's pro-tumourigenic activity. On the other hand, other recent findings have shown that immunogenic cancer cell death triggered by certain ...
Agostinis, P., Dudek, Aleksandra, Krysko, Dmitri V., Garg, A.D., Ruysscher, D. de, Garg, Abhishek, Agostinis, Patrizia, Krysko, D.V., Dudek, Aleksandra M, Garg, Abhishek D, De Ruysscher, Dirk, Krysko, Dmitri, Dudek, A.M.D.   +12 more
core   +4 more sources

Targeting immunogenic cell death for glioma immunotherapy

Trends in Cancer
Immunogenic cell death (ICD) arouses great interest in targeting glioma, the most common primary brain tumor, to achieve boosted immunotherapy. We discuss the unexpected findings on the induction of Th17 immunity by ICD and propose the best design for ...
Mishchenko, Tatiana A., Gorshkova, Ekaterina N., V. Vedunova, Maria, Turubanova, Victoria D., Krysko, Olga, Krysko, Dmitri   +5 more
core   +3 more sources