Results 11 to 20 of about 83,436 (250)
Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib
Frontiers in Oncology, 2021 Cabozantinib (XL-184) is a multitarget tyrosine kinase inhibitor (TKI) targeting receptor tyrosine kinases (RTKs) involved in oncogenesis and angiogenesis.
Fabio Scirocchi +7 more
doaj +4 more sources
Immunogenic Cell Death Induction by Ionizing Radiation [PDF]
Frontiers in Immunology, 2021 Immunogenic cell death (ICD) is a form of regulated cell death (RCD) induced by various stresses and produces antitumor immunity via damage-associated molecular patterns (DAMPs) release or exposure, mainly including high mobility group box 1 (HMGB1 ...
Mengqin Zhu +17 more
doaj +3 more sources
Immunogenicity of cell death driven by immune effectors [PDF]
Journal for ImmunoTherapy of Cancer, 2020 Whether cell death caused by T lymphocytes and natural killer (NK) cells would be immunogenic per se has been a matter of intense debate. Two back-to-back papers from the Melero’s and Pardo’s groups have now resolved this conundrum, demonstrating that T ...
Lorenzo Galluzzi +2 more
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Dynamical Boolean Modeling of Immunogenic Cell Death [PDF]
Frontiers in Physiology, 2020 As opposed to the standard tolerogenic apoptosis, immunogenic cell death (ICD) constitutes a type of cellular demise that elicits an adaptive immune response.
Andrea Checcoli +20 more
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Immunogenic Cell Death and Immunotherapy of Multiple Myeloma [PDF]
Frontiers in Cell and Developmental Biology, 2019 Over the past decades, immunotherapy has demonstrated a prominent clinical efficacy in a wide variety of human tumors. For many years, apoptosis has been considered a non-immunogenic or tolerogenic process whereas necrosis or necroptosis has long been ...
Alfonso Serrano-del Valle +3 more
doaj +3 more sources
eIF2α phosphorylation: A hallmark of immunogenic cell death [PDF]
OncoImmunology, 2018 Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely
Lucillia Bezu +5 more
doaj +3 more sources
Immunogenic and tolerogenic cell death [PDF]
Nature Reviews Immunology, 2009 The immune system is routinely exposed to dead cells during normal cell turnover, injury and infection. Mechanisms must exist to discriminate between different forms of cell death to correctly eliminate pathogens and promote healing while avoiding responses to self, which can result in autoimmunity.
Green, Douglas R. +3 more
openaire +2 more sources
Immunogenic cell death in cancer immunotherapy
BMB Reports, 2023 Cancer immunotherapy has been acknowledged as a new paradigm for cancer treatment, with notable therapeutic effects on certain cancer types. Despite their significant potential, clinical studies over the past decade have revealed that cancer immunotherapy has low response rates in the majority of solid tumors.
Minji Choi +7 more
openaire +2 more sources
Immunogenicity of necrotic cell death [PDF]
Cellular and Molecular Life Sciences, 2014 The mode of tumor cell death has significant effects on anti-tumor immunity. Although, previously it was thought that cell death is an inert effect, different investigators have clearly shown that dying tumors can attract, activate and mature professional antigen presenting cells and dendritic cells.
Jaba, Gamrekelashvili +2 more
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Immunogenic Cell Death in Cancer Therapy
Acta Naturae, 2022 Apoptosis plays a crucial role in chemotherapy-induced cell death. The conventional theory holding that apoptosis needs to be immunologically silent has recently been revised, and the concept of immunogenic cell death (ICD) has been proposed. This review describes the main features of ICD induction. These ICD markers are important for the effectiveness
Olga S. Troitskaya +3 more
openaire +2 more sources