Results 31 to 40 of about 6,745,376 (244)

Combinatorial Strategies for the Induction of Immunogenic Cell Death [PDF]

Frontiers in Immunology, 2015
The term "immunogenic cell death" (ICD) is commonly employed to indicate a peculiar instance of regulated cell death (RCD) that engages the adaptive arm of the immune system. The inoculation of cancer cells undergoing ICD into immunocompetent animals elicits a specific immune response associated with the establishment of immunological memory.
Bezu, Lucillia, Gomes-De-Silva, Ligia C., Dewitte, Heleen, Breckpot, Karine, Fucikova, Jitka, Spisek, Radek, Galluzzi, Lorenzo, Kepp, Oliver, Kroemer, Guido   +8 more
openaire   +7 more sources

Inhibitory DAMPs in immunogenic cell death and its clinical implications

Cell Stress, 2021
Dying (or dead) cells are increasingly recognized to impose significant biological influence within their tissues of residence—exerting paracrine effects through proteins and metabolites that are expressed or secreted during cellular demise. For example,
Kazukuni Hayashi, Fotis Nikolos, Keith S. Chan   +2 more
doaj   +1 more source

Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity

Frontiers in Oncology, 2023
Immunotherapy is widely regarded as a promising treatment for cancer. However, the immune effector phase suppression of tumor microenvironment (TME) and the generation of immune-related adverse events limit its application.
Ting Wang, Ting Wang, Wangrui Peng, Wangrui Peng, Meng Du, Meng Du, Zhiyi Chen, Zhiyi Chen, Zhiyi Chen   +8 more
doaj   +1 more source

Immunogenic chemotherapy sensitizes RAS-mutated colorectal cancers to immune checkpoint inhibitors

OncoImmunology, 2023
Recent clinical trials have compared the use of different chemotherapeutic regimens as “immune induction therapies” to sensitize cancers to immune checkpoint inhibitors (ICI).
Lucillia Bezu, Oliver Kepp, Guido Kroemer   +2 more
doaj   +1 more source

Lysosomal lipid peroxidation mediates immunogenic cell death

The Journal of Clinical Investigation, 2023
Cancer cells rely on lysosome-dependent degradation to recycle nutrients that serve their energetic and biosynthetic needs. Despite great interest in repurposing the antimalarial hydroxychloroquine as a lysosomal inhibitor in clinical oncology trials ...
Pravin Phadatare, Jayanta Debnath
doaj   +1 more source

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]

, 2014
The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-
Rodhe, J, Venero, JL, Rodhe, J,, Rodhe, Johanna, Joseph, B, Burguillos García, Miguel Ángel, Venero Recio, José Luis, Kavanagh, E, Burguillos, MA, Kavanagh, Edel T., Joseph, Bertrand, Joseph, B,   +11 more
core   +1 more source

Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer

, 2020
Oncolytic viruses have the potential to induce immunogenic cell death (ICD) that may provoke potent and long-lasting anti-cancer immunity. Here we aimed to characterize the ICD-inducing ability of wild-type Adenovirus (Ad), Semliki Forest virus (SFV) and
Jin, Chuan, Martikainen, Miika,, Ramachandran, Mohanraj, Ramachandran, Mohanraj,, Quijano-Rubio, Clara,, Jin, Chuan,, Yu, Di, Ma, Jing, Quijano-Rubio, Clara, Ma, Jing,, Essand, Magnus, Martikainen, Miika, Yu, Di,, Essand, Magnus,   +13 more
core   +1 more source

Viral strategies for the evasion of immunogenic cell death [PDF]

Journal of Internal Medicine, 2010
Abstract.  Galluzzi L, Kepp O, Morselli E, Vitale I, Senovilla L, Pinti M, Zitvogel L, Kroemer G (INSERM, U848; Institut Gustave Roussy; and Université Paris Sud‐XI, Paris, France; Università degli studi di Modena e Reggio Emilia, Modena, Italy; INSERM, U805, Paris, France). Viral strategies for the evasion of immunogenic cell death (Symposium).
GALLUZZI, Lorenzo, Kepp O, MORSELLI, EUGENIA, Vitale I, Senovilla L, PINTI, Marcello, Zitvogel L, Kroemer G.   +7 more
openaire   +3 more sources

Non-thermal plasma induces immunogenic cell death in vivo in murine CT26 colorectal tumors

OncoImmunology, 2018
Immunogenic cell death is characterized by the emission of danger signals that facilitate activation of an adaptive immune response against dead-cell antigens.
Abraham G. Lin, Bo Xiang, Dante J. Merlino, Trevor R. Baybutt, Joya Sahu, Alexander Fridman, Adam E. Snook, Vandana Miller   +7 more
doaj   +1 more source

Immunogenic effects of chemotherapy-induced tumor cell death

Genes and Diseases, 2018
Emerging evidence suggests that the clinical success of conventional chemotherapy is not solely attributed to tumor cell toxicity, but also results from the restoration of immunosurveillance, which has been largely neglected in the past preclinical and ...
Yi-Jun Wang, Rochelle Fletcher, Jian Yu, Lin Zhang   +3 more
doaj   +1 more source