Results 31 to 40 of about 83,436 (250)

Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity

Frontiers in Oncology, 2023
Immunotherapy is widely regarded as a promising treatment for cancer. However, the immune effector phase suppression of tumor microenvironment (TME) and the generation of immune-related adverse events limit its application.
Ting Wang, Ting Wang, Wangrui Peng, Wangrui Peng, Meng Du, Meng Du, Zhiyi Chen, Zhiyi Chen, Zhiyi Chen   +8 more
doaj   +1 more source

Immunogenic chemotherapy sensitizes RAS-mutated colorectal cancers to immune checkpoint inhibitors

OncoImmunology, 2023
Recent clinical trials have compared the use of different chemotherapeutic regimens as “immune induction therapies” to sensitize cancers to immune checkpoint inhibitors (ICI).
Lucillia Bezu, Oliver Kepp, Guido Kroemer   +2 more
doaj   +1 more source

Lysosomal lipid peroxidation mediates immunogenic cell death

The Journal of Clinical Investigation, 2023
Cancer cells rely on lysosome-dependent degradation to recycle nutrients that serve their energetic and biosynthetic needs. Despite great interest in repurposing the antimalarial hydroxychloroquine as a lysosomal inhibitor in clinical oncology trials ...
Pravin Phadatare, Jayanta Debnath
doaj   +1 more source

Dying of Stress: Chemotherapy, Radiotherapy, and Small-Molecule Inhibitors in Immunogenic Cell Death and Immunogenic Modulation

Cells, 2022
Innovative strategies to re-establish the immune-mediated destruction of malignant cells is paramount to the success of anti-cancer therapy. Accumulating evidence suggests that radiotherapy and select chemotherapeutic drugs and small molecule inhibitors ...
Kellsye P. Fabian, Joshua T. Kowalczyk, Sandy T. Reynolds, James W. Hodge   +3 more
doaj   +1 more source

Non-thermal plasma induces immunogenic cell death in vivo in murine CT26 colorectal tumors

OncoImmunology, 2018
Immunogenic cell death is characterized by the emission of danger signals that facilitate activation of an adaptive immune response against dead-cell antigens.
Abraham G. Lin, Bo Xiang, Dante J. Merlino, Trevor R. Baybutt, Joya Sahu, Alexander Fridman, Adam E. Snook, Vandana Miller   +7 more
doaj   +1 more source

Immunogenic effects of chemotherapy-induced tumor cell death

Genes and Diseases, 2018
Emerging evidence suggests that the clinical success of conventional chemotherapy is not solely attributed to tumor cell toxicity, but also results from the restoration of immunosurveillance, which has been largely neglected in the past preclinical and ...
Yi-Jun Wang, Rochelle Fletcher, Jian Yu, Lin Zhang   +3 more
doaj   +1 more source

Molecular characteristics of immunogenic cancer cell death [PDF]

Cell Death & Differentiation, 2007
Apoptotic cell death is initiated by a morphologically homogenous entity that was considered to be non-immunogenic and non-inflammatory in nature. However, recent advances suggest that apoptosis, under certain circumstances, can be immunogenic. In particular, some characteristics of the plasma membrane, acquired at preapoptotic stage, can cause immune ...
A, Tesniere, T, Panaretakis, O, Kepp, L, Apetoh, F, Ghiringhelli, L, Zitvogel, G, Kroemer   +6 more
openaire   +2 more sources

Nanotechnology-Assisted Immunogenic Cell Death for Effective Cancer Immunotherapy

Vaccines, 2023
Tumor vaccines have been used to treat cancer. How to efficiently induce tumor-associated antigens (TAAs) secretion with host immune system activation is a key issue in achieving high antitumor immunity. Immunogenic cell death (ICD) is a process in which
Yichen Guo, Rong Ma, Mengzhe Zhang, Yongjian Cao, Zhenzhong Zhang, Weijing Yang   +5 more
doaj   +1 more source

Consensus guidelines for the detection of immunogenic cell death [PDF]

OncoImmunology, 2014
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named "immunogenic cell death" (ICD).
Oliver Kepp, Norma Bloy, Laura Bracci, Karine Breckpot, David Brough, Aitziber Buqu, Maria Castro, G., Mara Cirone, Maria Colombo, I., Isabelle Cremer, Sandra Demaria, Laura Senovilla, Luciana Dini, Aristides Eliopoulos, G., Alberto Faggioni, Silvia Formenti, C., Jitka Fukov, Lucia Gabriele, Udo Gaipl, S., Jrme Galon, Abhishek Garg, Franois Ghiringhelli, Ilio Vitale, Nathalia Giese, A., Zong Sheng Guo, Akseli Hemminki, Martin Herrmann, James Hodge, W., Stefan Holdenrieder, Jamie Honeychurch, Hong-min Hu, Xing Huang, Tim Illidge, M., Erika Vacchelli, Koji Konoa, Mladen Korbelik, Dmitri Krysko, V., Sherene Loi, Pedro Lowenstein, R., Enrico Lugli, Yuting Ma, Frank Madeo, Angelo Manfredi, A., Isabelle Martins, Sandy Adjemian, Domenico Mavilio, Laurie Menger, Merendino, Nicolo', Michael Michaud, Gregoire Mignot, Karen Mossman, L., Gabriele Multhoff, Rudolf Oehler, Fabio Palombo, Theocharis Panaretakis, Patrizia Agostini, Jonathan Pol, Enrico Proietti, Jean-ehrland Ricci, Chiara Riganti, Patrizia Rovere-querini, Anna Rubartelli, Antonella Sistigu, Mark Smyth, J., Juergen Sonnemann, Radek Spisek, Lionel Apetoh, John Stagg, Abdul Qader Sukkurwala, Eric Tartour, Andrew Thorburn, Stephen Thorne, H., Peter Vandenabeele, Francesca Velotti, Samuel Workenhe, T., Haining Yang, Wei-xing Zong, Fernando Aranda, Laurence Zitvogel, Guido Kroemer Lorenzo Galluzzi, Kepp, O., Senovilla, L., Velotti, Francesca Romana, Galluzzi, L., Vincenzo Barnaba   +84 more
openaire   +7 more sources

Immunogenic cell death: The cornerstone of oncolytic viro-immunotherapy

Frontiers in Immunology, 2023
According to the World Health Organization, cancer is one of the leading global health concerns, causing nearly 10 million deaths in 2020. While classical chemotherapeutics produce strong cytotoxicity on cancer cells, they carry limitations of drug ...
Lalitha Palanivelu, Ching-Hsuan Liu, Ching-Hsuan Liu, Ching-Hsuan Liu, Liang-Tzung Lin, Liang-Tzung Lin   +5 more
doaj   +1 more source