Results 31 to 40 of about 7,237,819 (287)

Immunogenic cell death in radiation therapy [PDF]

OncoImmunology, 2013
Radiation therapy has been extensively employed throughout the last century to treat individuals affected by multiple types of tumors, with a variable degree of success. Current estimates indicate indeed that at least 50% of cancer patients all confounded have been or will be exposed to ionizing irradiation, either as a standalone intervention or ...
Galluzzi, Lorenzo, Kepp, Oliver, Kroemer, Guido   +2 more
openaire   +2 more sources

Immunogenic cell death

The International Journal of Developmental Biology, 2015
Currently, it is widely acknowledged that a proactive anticancer immunosurveillance mechanism takes part in the rejection of neoplastic lesions before they progress towards a benign or malignant tumour. However in cases of very aggressive neoplastic lesions consisting of cells with high mutational diversity, cancer cell variants might be formed that ...
Garg, Abhishek, Dudek-Peric, Aleksandra M., Romano, Erminia, Agostinis, Patrizia   +3 more
openaire   +4 more sources

Measles virus causes immunogenic cell death in human melanoma [PDF]

, 2011
NoOncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma.
Russell, S, Selby, P., Hadac, E., Donnelly, Oliver G, Jennings, V., Errington-Mais, F., Melcher, Alan A, Hadac, Elizabeth, Bond, J, Melcher, A.A., Bond, Jacquelyn, Selby, P, Bond, J., Peach, H., Vile, Richard, Steele, L., Vile, R., Hadac, E, Donnelly, O.G., Russell, Stephen, Harrington, K.J., Harrington, K, Peach, Howard, Steele, Lynette, Melcher, AA, Errington-Mais, Fiona, Harrington, Kevin, Russell, S., Phillips, Roger M., Pandha, H.S., Selby, Peter, Errington-Mais, F, Jennings, V, Scott, K, Phillips, RM, Phillips, Roger M, Scott, K., Pandha, Hardev, Vile, R, Jennings, Victoria, Steele, L, Pandha, H, Scott, Karen, Donnelly, OG, Peach, H   +44 more
core   +1 more source

Radiotherapy and Immunogenic Cell Death

Seminars in Radiation Oncology, 2015
Advances in understanding the mechanisms that underlie the interplay between radiation-invoked immune responses and tumor regression are underway. Emerging applications of local radiotherapy as an immunologic adjuvant have provided radiation oncologists with a method for converting malignant cells into endogenous anticancer vaccines.
Golden, Encouse B., Apetoh, Lionel
openaire   +2 more sources

Inhibitory DAMPs in immunogenic cell death and its clinical implications

Cell Stress, 2021
Dying (or dead) cells are increasingly recognized to impose significant biological influence within their tissues of residence—exerting paracrine effects through proteins and metabolites that are expressed or secreted during cellular demise. For example,
Kazukuni Hayashi, Fotis Nikolos, Keith S. Chan   +2 more
doaj   +1 more source

Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity

Frontiers in Oncology, 2023
Immunotherapy is widely regarded as a promising treatment for cancer. However, the immune effector phase suppression of tumor microenvironment (TME) and the generation of immune-related adverse events limit its application.
Ting Wang, Ting Wang, Wangrui Peng, Wangrui Peng, Meng Du, Meng Du, Zhiyi Chen, Zhiyi Chen, Zhiyi Chen   +8 more
doaj   +1 more source

Autophagy Modulates Immunogenic Cell Death in Cancer. [PDF]

Cancers (Basel)
Immunogenic cell death (ICD) is a subtype of regulated cell death characterized by the spatiotemporally coordinated emission of damage-associated molecular patterns (DAMPs), such as calreticulin (CALR), ATP, and high-mobility group box-1 (HMGB1), which collectively prime tumor-specific T-cell responses. Autophagy, a lysosome-dependent catabolic process,
Matsushita M, Moriwaki M.
europepmc   +4 more sources

Immunogenic chemotherapy sensitizes RAS-mutated colorectal cancers to immune checkpoint inhibitors

OncoImmunology, 2023
Recent clinical trials have compared the use of different chemotherapeutic regimens as “immune induction therapies” to sensitize cancers to immune checkpoint inhibitors (ICI).
Lucillia Bezu, Oliver Kepp, Guido Kroemer   +2 more
doaj   +1 more source

A Functional Assay to Determine the Capacity of Oncolytic Viruses to Induce Immunogenic Tumor Cell Death

, 2020
International audienceOncolytic immunotherapy efficacy relies partially on the induction of immunogenic tumor cell death following infection with oncolytic viruses (OV) to induce an antitumor immune response. Here, we describe a method to determine if an
Delaunay, Tiphaine, Tangy, Frédéric, Gregoire, Marc, Boisgerault, Nicolas, Achard, Carole, Fonteneau, Jean-François   +5 more
core   +1 more source

Immunogenic cell death and immunogenic surrender- related but distinct mechanisms of immune surveillance

, 2022
10.1038/s41419-021-04178-6original data for figures 1 and 2 of the review: Immunogenic cell death and immunogenic surrender- related but distinct mechanisms of immune surveillance.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
crippa, M (via Mendeley Data), crippa, massimo   +1 more
core   +1 more source