Results 211 to 220 of about 6,745,376 (244)

Characterization of Full‐Length Antibody Complexes Through HDX‐Mass Spectrometry Coupled With NMR Spectroscopy: New Insight Into Avelumab/PD‐L1 Interaction

Angewandte Chemie, EarlyView.
Combining HDX‐MS and NMR enables the mapping of epitopes and paratopes in full‐length antibody complexes, revealing transient interactions and potential artifacts. ABSTRACT Recombinant biomacromolecules have significantly transformed pharmaceuticals, in particular monoclonal antibodies (mAbs) that target key areas in oncology, immunology, inflammation,
Francesca Sacco, Fabio Baroni, Angela Capolupo, Sofia Petrocchi, Jonathan Zöller, Linda Cerofolini, Pasquale Russomanno, Rebecca Calamandrei, Bianca Susini, Siyu Lin, Fabio D'Amici, Enrico Ravera, Julian Langer, Marco Fragai   +13 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Immunogenic Cell Death Inducing Metal Complexes for Cancer Therapy

Angewandte Chemie - International Edition, 2023
Cancer is one of the deadliest diseases worldwide. Recent statistics have shown that metastases and tumor relapse are the leading causes of cancer-associated deaths. While traditional treatments are able to efficiently remove the primary tumor, secondary
Johannes Karges
exaly   +1 more source

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Immunogenic cell stress and death

Nature Immunology, 2022
Dying mammalian cells emit numerous signals that interact with the host to dictate the immunological correlates of cellular stress and death. In the absence of reactive antigenic determinants (which is generally the case for healthy cells), such signals may drive inflammation but cannot engage adaptive immunity.
Guido Kroemer, Claudia Galassi, Laurence Zitvogel, Lorenzo Galluzzi   +3 more
openaire   +2 more sources

Biomaterials That Induce Immunogenic Cell Death

Small Methods, 2023
AbstractThe immune system takes part in most physiological and pathological processes of the body, including the occurrence and development of cancer. Immunotherapy provides a promising modality for inhibition and even the cure of cancer. During immunotherapy, the immunogenic cell death (ICD) of tumor cells induced by chemotherapy, radiotherapy ...
Di Li, Siqi Liu, Yang Ma, Shixian Liu, Yahui Liu, Jianxun Ding   +5 more
openaire   +2 more sources

The immunogenicity of tumor cell death

Current Opinion in Oncology, 2009
It is an ongoing conundrum under which circumstances cellular demise induces an immune response and whether apoptotic or necrotic cells are intrinsically immunogenic or tolerogenic. This review summarizes recent insights in the immunogenicity of dying tumor cells.Although apoptosis appears to be morphologically homogeneous, recent evidence suggests ...
Oliver, Kepp, Antoine, Tesniere, Laurence, Zitvogel, Guido, Kroemer   +3 more
openaire   +2 more sources

Immunogenic Cell Death in Cancer Therapy

Annual Review of Immunology, 2013
Depending on the initiating stimulus, cancer cell death can be immunogenic or nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the cell surface as well as the release of soluble mediators, occurring in a defined temporal sequence. Such signals operate on a series of receptors expressed by dendritic cells to stimulate
Guido, Kroemer, Lorenzo, Galluzzi, Oliver, Kepp, Laurence, Zitvogel   +3 more
openaire   +2 more sources

Immunogenic cell death in cancer and infectious disease

Nature Reviews Immunology, 2016
Immunogenicity depends on two key factors: antigenicity and adjuvanticity. The presence of exogenous or mutated antigens explains why infected cells and malignant cells can initiate an adaptive immune response provided that the cells also emit adjuvant signals as a consequence of cellular stress and death.
Oliver Kepp, Aitziber Buque, Guido Kroemer   +2 more
exaly   +3 more sources

Immunogenic and Non-immunogenic Cell Death in the Tumor Microenvironment

2017
The host immune system is continuously exposed to dying cells and has evolved to distinguish between cell death events signaling potential threats and physiological apoptosis that should be tolerated. Tumors can use this distinction to their advantage, promoting apoptotic death of cancer cells to induce tolerance and evasion of immunosurveillance.
Jonathan M, Pitt, Guido, Kroemer, Laurence, Zitvogel   +2 more
openaire   +2 more sources

DAMPs in the immunogenicity of cell death

Molecular Cell
Damage-associated molecular patterns (DAMPs) are endogenous molecules-such as proteins, lipids, and nucleic acids-released or exposed during cellular injury or stress, which shape immune responses by engaging danger sensors on the cell surface or within the cell interior.
Ruochan, Chen, Ju, Zou, Jiao, Liu, Rui, Kang, Daolin, Tang   +4 more
openaire   +2 more sources