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Immunogenic cell death and DAMPs in cancer therapy
Nature Reviews Cancer, 2012Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent death that did not trigger an immune response, in recent years a new concept of immunogenic cell death (ICD) has emerged. The immunogenic characteristics of ICD are mainly mediated by damage-associated molecular patterns (DAMPs), which include surface-exposed ...
Krysko, Dmitri V. +5 more
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Natural modulators of the hallmarks of immunogenic cell death
Biochemical Pharmacology, 2019Natural compounds act as immunoadjuvants as their therapeutic effects trigger cancer stress response and release of damage-associated molecular patterns (DAMPs). These reactions occur through an increase in the immunogenicity of cancer cells that undergo stress followed by immunogenic cell death (ICD).
Flavia Radogna +2 more
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Cancer cell death: Cell-autonomous and immunogenic dimensions
Cancer CellRegulated cell death (RCD) shapes neoplastic transformation, tumor progression, and response to treatment. While apoptosis was long viewed as the only RCD variant, additional modalities, including necroptosis, pyroptosis, and ferroptosis, have been characterized.
Lorenzo Galluzzi +4 more
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The inducers of immunogenic cell death for tumor immunotherapy
Tumori Journal, 2018Immunotherapy is a promising treatment modality that acts by selectively harnessing the host immune defenses against cancer. An effective immune response is often needed to eliminate tumors following treatment which can trigger the immunogenicity of dying tumor cells.
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CX3CL1: a key switch of cell death immunogenicity
Trends in CancerCX3CL1 (fractalkine) is a unique chemokine with dual roles in cancer biology, capable of exerting both tumor-promoting and tumor-suppressive effects. Acting through its receptor CX3CR1, CX3CL1 facilitates immune evasion, angiogenesis, metastasis, and tumor cell survival and proliferation by recruiting immunosuppressive myeloid-derived suppressor cells.
Robin Demuynck +2 more
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Anticancer metal drugs and immunogenic cell death
Journal of Inorganic Biochemistry, 2016Conventional chemotherapeutics, but also innovative precision anticancer compounds, are commonly perceived to target primarily the cancer cell compartment. However, recently it was discovered that some of these compounds can also exert immunomodulatory activities which might be exploited to synergistically enhance their anticancer effects. One specific
Alessio Terenzi +3 more
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Methods to Detect Immunogenic Cell Death In Vivo
2019In response to selected stressors, cancer cells can undergo a form of regulated cell death that-in immunocompetent syngeneic hosts-is capable of eliciting an adaptive immune response specific for dead cell-associated antigens. Thus, such variant of regulated cell death manifests with robust antigenicity and adjuvanticity.
Takahiro, Yamazaki +5 more
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