Results 261 to 270 of about 129,949 (299)

Biomaterials That Induce Immunogenic Cell Death

Small Methods, 2023
AbstractThe immune system takes part in most physiological and pathological processes of the body, including the occurrence and development of cancer. Immunotherapy provides a promising modality for inhibition and even the cure of cancer. During immunotherapy, the immunogenic cell death (ICD) of tumor cells induced by chemotherapy, radiotherapy ...
Di Li, Siqi Liu, Yang Ma, Shixian Liu, Yahui Liu, Jianxun Ding   +5 more
openaire   +2 more sources

Immunogenic Cell Death in Cancer Therapy

Annual Review of Immunology, 2013
Depending on the initiating stimulus, cancer cell death can be immunogenic or nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the cell surface as well as the release of soluble mediators, occurring in a defined temporal sequence. Such signals operate on a series of receptors expressed by dendritic cells to stimulate
Guido, Kroemer, Lorenzo, Galluzzi, Oliver, Kepp, Laurence, Zitvogel   +3 more
openaire   +2 more sources

Inducers of immunogenic cancer cell death

Cytokine & Growth Factor Reviews, 2013
Recently, cytokine-based pro-tumourigenic signalling has been found to play a major role in the immune system's pro-tumourigenic activity. On the other hand, other recent findings have shown that immunogenic cancer cell death triggered by certain anticancer modalities might reset the dysfunctional immune system towards the activation of a long-lasting ...
Dudek, A.M.D., Dudek, A.M.D., Garg, A.D., Krysko, D.V., de Ruysscher, D., Agostinis, P.   +5 more
openaire   +3 more sources

The immunogenicity of tumor cell death

Current Opinion in Oncology, 2009
It is an ongoing conundrum under which circumstances cellular demise induces an immune response and whether apoptotic or necrotic cells are intrinsically immunogenic or tolerogenic. This review summarizes recent insights in the immunogenicity of dying tumor cells.Although apoptosis appears to be morphologically homogeneous, recent evidence suggests ...
Oliver, Kepp, Antoine, Tesniere, Laurence, Zitvogel, Guido, Kroemer   +3 more
openaire   +2 more sources

Anticancer metal drugs and immunogenic cell death

Journal of Inorganic Biochemistry, 2016
Conventional chemotherapeutics, but also innovative precision anticancer compounds, are commonly perceived to target primarily the cancer cell compartment. However, recently it was discovered that some of these compounds can also exert immunomodulatory activities which might be exploited to synergistically enhance their anticancer effects. One specific
Alessio Terenzi, Christine Pirker, Bernhard K. Keppler, Walter Berger   +3 more
openaire   +3 more sources

Immunogenic and Non-immunogenic Cell Death in the Tumor Microenvironment

2017
The host immune system is continuously exposed to dying cells and has evolved to distinguish between cell death events signaling potential threats and physiological apoptosis that should be tolerated. Tumors can use this distinction to their advantage, promoting apoptotic death of cancer cells to induce tolerance and evasion of immunosurveillance.
Jonathan M, Pitt, Guido, Kroemer, Laurence, Zitvogel   +2 more
openaire   +2 more sources

Microbes mediated immunogenic cell death in cancer immunotherapy

Immunological Reviews, 2023
SummaryImmunogenic cell death (ICD) is one of the 12 distinct cell death forms, which can trigger immune system to fight against cancer cells. During ICD, a number of cellular changes occur that can stimulate an immune response, including the release of molecules called damage‐associated molecular patterns (DAMPs), signaling to immune cells to ...
Jumin Huang, Fugang Duan, Chun Xie, Jiahui Xu, Yizhong Zhang, Yuwei Wang, Yu‐Ping Tang, Elaine Lai‐Han Leung   +7 more
openaire   +2 more sources

Targeting immunogenic cell death for glioma immunotherapy

Trends in Cancer
Immunogenic cell death (ICD) arouses great interest in targeting glioma, the most common primary brain tumor, to achieve boosted immunotherapy. We discuss the unexpected findings on the induction of Th17 immunity by ICD and propose the best design for dendritic cell (DC)-based vaccines loaded with whole glioma lysates obtained after ICD inducers.
Tatiana A. Mishchenko, Victoria D. Turubanova, Ekaterina N. Gorshkova, Olga Krysko, Maria V. Vedunova, Dmitri V. Krysko   +5 more
openaire   +2 more sources

Immunogenic Apoptotic Cell Death and Anticancer Immunity

2016
For many years it has been thought that apoptotic cells rapidly cleared by phagocytic cells do not trigger an immune response but rather have anti-inflammatory properties. However, accumulating experimental data indicate that certain anticancer therapies can induce an immunogenic form of apoptosis associated with the emission of damage-associated ...
Peter, Vandenabeele, Katrien, Vandecasteele, Claus, Bachert, Olga, Krysko, Dmitri V, Krysko   +4 more
openaire   +2 more sources

Immunogenic cell death and DAMPs in cancer therapy

Nature Reviews Cancer, 2012
Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent death that did not trigger an immune response, in recent years a new concept of immunogenic cell death (ICD) has emerged. The immunogenic characteristics of ICD are mainly mediated by damage-associated molecular patterns (DAMPs), which include surface-exposed ...
Krysko, Dmitri V., Garg, Abhishek D., Kaczmarek, Agnieszka, Krysko, Olga, Agostinis, Patrizia, Vandenabeele, Peter   +5 more
openaire   +2 more sources