Results 261 to 270 of about 131,333 (298)

Belantamab Mafodotin Triggers Immune Invigoration in Multiple Myeloma Via Inflammatory and Immunogenic Cell Death

Watson EC, Shuwa HA, Heycock M, Wade J, Wang C, Htun M, Li L, Niehaus V, Baker W, Miller B, Drews RM, Barber PR, Ma Y, Munera D, Hong Q, Lowther DE, Aksu AC, Lee L, Eberl HC, Calcutt E, Gooding S, Shen Y, Khan A, Hester J, Issa F, Napolitani G, Musa H, Ramasamy K, Oppermann U, Griffin S.   +29 more
europepmc   +1 more source

Targeting immunogenic cell death in cancer [PDF]

Molecular Oncology, 2020
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic therapy, and radiotherapy. It involves the activation of the immune system against cancer in immunocompetent hosts.
Asma Ahmed, Stephen W G Tait
exaly   +4 more sources

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Immunogenic cell stress and death

Nature Immunology, 2022
Dying mammalian cells emit numerous signals that interact with the host to dictate the immunological correlates of cellular stress and death. In the absence of reactive antigenic determinants (which is generally the case for healthy cells), such signals may drive inflammation but cannot engage adaptive immunity.
Guido Kroemer, Claudia Galassi, Laurence Zitvogel, Lorenzo Galluzzi   +3 more
openaire   +2 more sources

Biomaterials That Induce Immunogenic Cell Death

Small Methods, 2023
AbstractThe immune system takes part in most physiological and pathological processes of the body, including the occurrence and development of cancer. Immunotherapy provides a promising modality for inhibition and even the cure of cancer. During immunotherapy, the immunogenic cell death (ICD) of tumor cells induced by chemotherapy, radiotherapy ...
Di Li, Siqi Liu, Yang Ma, Shixian Liu, Yahui Liu, Jianxun Ding   +5 more
openaire   +2 more sources

Immunogenic cell death and DAMPs in cancer therapy

Nature Reviews Cancer, 2012
Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent death that did not trigger an immune response, in recent years a new concept of immunogenic cell death (ICD) has emerged. The immunogenic characteristics of ICD are mainly mediated by damage-associated molecular patterns (DAMPs), which include surface-exposed ...
Dmitri V Krysko, Abhishek D Garg, Agnieszka Kaczmarek   +2 more
exaly   +3 more sources

The immunogenicity of tumor cell death

Current Opinion in Oncology, 2009
It is an ongoing conundrum under which circumstances cellular demise induces an immune response and whether apoptotic or necrotic cells are intrinsically immunogenic or tolerogenic. This review summarizes recent insights in the immunogenicity of dying tumor cells.Although apoptosis appears to be morphologically homogeneous, recent evidence suggests ...
Oliver, Kepp, Antoine, Tesniere, Laurence, Zitvogel, Guido, Kroemer   +3 more
openaire   +2 more sources

Immunogenic Cell Death in Cancer Therapy

Annual Review of Immunology, 2013
Depending on the initiating stimulus, cancer cell death can be immunogenic or nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the cell surface as well as the release of soluble mediators, occurring in a defined temporal sequence. Such signals operate on a series of receptors expressed by dendritic cells to stimulate
Guido, Kroemer, Lorenzo, Galluzzi, Oliver, Kepp, Laurence, Zitvogel   +3 more
openaire   +2 more sources

Inducers of immunogenic cancer cell death

Cytokine & Growth Factor Reviews, 2013
Recently, cytokine-based pro-tumourigenic signalling has been found to play a major role in the immune system's pro-tumourigenic activity. On the other hand, other recent findings have shown that immunogenic cancer cell death triggered by certain anticancer modalities might reset the dysfunctional immune system towards the activation of a long-lasting ...
Dudek, A.M.D., Dudek, A.M.D., Garg, A.D., Krysko, D.V., de Ruysscher, D., Agostinis, P.   +5 more
openaire   +3 more sources

Immunogenic and Non-immunogenic Cell Death in the Tumor Microenvironment

2017
The host immune system is continuously exposed to dying cells and has evolved to distinguish between cell death events signaling potential threats and physiological apoptosis that should be tolerated. Tumors can use this distinction to their advantage, promoting apoptotic death of cancer cells to induce tolerance and evasion of immunosurveillance.
Jonathan M, Pitt, Guido, Kroemer, Laurence, Zitvogel   +2 more
openaire   +2 more sources

DAMPs in the immunogenicity of cell death

Molecular Cell
Damage-associated molecular patterns (DAMPs) are endogenous molecules-such as proteins, lipids, and nucleic acids-released or exposed during cellular injury or stress, which shape immune responses by engaging danger sensors on the cell surface or within the cell interior.
Ruochan, Chen, Ju, Zou, Jiao, Liu, Rui, Kang, Daolin, Tang   +4 more
openaire   +2 more sources