Results 261 to 270 of about 7,237,819 (287)
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DAMPs in the immunogenicity of cell death
Molecular CellDamage-associated molecular patterns (DAMPs) are endogenous molecules-such as proteins, lipids, and nucleic acids-released or exposed during cellular injury or stress, which shape immune responses by engaging danger sensors on the cell surface or within the cell interior.
Ruochan, Chen +4 more
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Immunogenic cell death in cancer and infectious disease
Nature Reviews Immunology, 2016Immunogenicity depends on two key factors: antigenicity and adjuvanticity. The presence of exogenous or mutated antigens explains why infected cells and malignant cells can initiate an adaptive immune response provided that the cells also emit adjuvant signals as a consequence of cellular stress and death.
Lorenzo Galluzzi +4 more
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Natural modulators of the hallmarks of immunogenic cell death
Biochemical Pharmacology, 2019Natural compounds act as immunoadjuvants as their therapeutic effects trigger cancer stress response and release of damage-associated molecular patterns (DAMPs). These reactions occur through an increase in the immunogenicity of cancer cells that undergo stress followed by immunogenic cell death (ICD).
Flavia Radogna +2 more
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Cancer cell death: Cell-autonomous and immunogenic dimensions
Cancer CellRegulated cell death (RCD) shapes neoplastic transformation, tumor progression, and response to treatment. While apoptosis was long viewed as the only RCD variant, additional modalities, including necroptosis, pyroptosis, and ferroptosis, have been characterized.
Lorenzo Galluzzi +4 more
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CX3CL1: a key switch of cell death immunogenicity
Trends in CancerCX3CL1 (fractalkine) is a unique chemokine with dual roles in cancer biology, capable of exerting both tumor-promoting and tumor-suppressive effects. Acting through its receptor CX3CR1, CX3CL1 facilitates immune evasion, angiogenesis, metastasis, and tumor cell survival and proliferation by recruiting immunosuppressive myeloid-derived suppressor cells.
Robin Demuynck +2 more
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Anticancer metal drugs and immunogenic cell death
Journal of Inorganic Biochemistry, 2016Conventional chemotherapeutics, but also innovative precision anticancer compounds, are commonly perceived to target primarily the cancer cell compartment. However, recently it was discovered that some of these compounds can also exert immunomodulatory activities which might be exploited to synergistically enhance their anticancer effects. One specific
Alessio Terenzi +3 more
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Methods to Detect Immunogenic Cell Death In Vivo
2019In response to selected stressors, cancer cells can undergo a form of regulated cell death that-in immunocompetent syngeneic hosts-is capable of eliciting an adaptive immune response specific for dead cell-associated antigens. Thus, such variant of regulated cell death manifests with robust antigenicity and adjuvanticity.
Takahiro, Yamazaki +5 more
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Roles of RIPK1 as a Stress Sentinel Coordinating Cell Survival and Immunogenic Cell Death
Nature Reviews Molecular Cell Biology, 2023Pascal Meier, Jarama Clucas
exaly