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Natural compound inducers of immunogenic cell death
Archives of Pharmacal Research, 2019Accumulating evidence shows that the anti-cancer potential of the immune response that can be activated by modulation of the immunogenicity of dying cancer cells. This regulated cell death process is called immunogenic cell death (ICD) and constitutes a new innovating anti-cancer strategy with immune-modulatory potential thanks to the release of damage-
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Crosstalk between ER stress and immunogenic cell death
Cytokine & Growth Factor Reviews, 2013Preclinical and clinical findings suggest that tumor-specific immune responses may be responsible--at least in part--for the clinical success of therapeutic regimens that rely on immunogenic cell death (ICD) inducers, including anthracyclines and oxaliplatin.
Oliver Kepp +12 more
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Targeting Mutant KRAS for Immunogenic Cell Death Induction
Trends in Pharmacological Sciences, 2020Although somatic KRAS mutations are common in human tumors, no inhibitor of mutant KRAS was clinically available until recently. Canon and colleagues describe the ability of a clinically available KRASG12C inhibitor to drive immunogenic cancer cell death, thus constituting a promising combinatorial partner for immune checkpoint blockers.
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[Immunogenic cell death in hematological malignancies].
[Rinsho ketsueki] The Japanese journal of clinical hematology, 2021Anticancer therapies using cytotoxic drugs, which had been considered to be immunosuppressive, could induce immunogenic cell death (ICD) in cancer cells. Anticancer drugs, tumor-lytic viruses, and radiation therapies can establish long-term immune memory via emmision of damage-associated molecular pattern from cancer cells, activating the acquired ...
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Tartrolon D induces immunogenic cell death in melanoma
Chemico-Biological InteractionsTartrolon D (TRL) is produced by Teredinibacter turnerae, a symbiotic cellulose-degrading bacteria in shipworm gills. Immunogenic cell death (ICD) induction contributes to a better and longer-lasting response to anticancer treatment. Tumor cells undergoing ICD trigger activation of the immune system, as a vaccine.This study aimed to evaluate ICD ...
Thaís Lima de Brito +9 more
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