Results 131 to 140 of about 441,484 (310)

Immunogenicity of NS4b dengue 3 virus mimotope presented to the immune system as multiple antigen peptide system [PDF]

, 2013
The availability of random peptide libraries displayed on bacteriophage (RPL) has provided a powerful tool for selecting sequences that mimic binding properties of natural antigen epitopes (mimotopes). These mimotopes can be used for vaccine design, drug
Acosta, Armando, Aguilar, Alicia, Alvarez, Mayling, Amin, Nevis, Caballero, Yamira, Camacho, Frank, Díaz, Daiyana, García, Angélica, Guzmán, María Guadalupe, Pupo, Maritza, Reyes, Osvalda, Stott, David I.   +11 more
core   +2 more sources

Minimal Immunogenic Epitopes Have Nine Amino Acids [PDF]

arXiv, 2016
To be cost-effective, biomedical proteins must be optimized with regard to many factors. Road maps are customary for large-scale projects, and here descriptive methods based on bioinformatic fractal thermodynamic scales are tested against an important example, HPV vaccine.
arxiv  

Immunogenic cell death

The International Journal of Developmental Biology, 2015
Currently, it is widely acknowledged that a proactive anticancer immunosurveillance mechanism takes part in the rejection of neoplastic lesions before they progress towards a benign or malignant tumour. However in cases of very aggressive neoplastic lesions consisting of cells with high mutational diversity, cancer cell variants might be formed that ...
Garg, Abhishek, Dudek-Peric, Aleksandra M., Romano, Erminia, Agostinis, Patrizia   +3 more
openaire   +5 more sources

Recent Developments in Immune Network Theory including a concept for an HIV Vaccine [PDF]

arXiv, 2008
The symmetrical network theory is a framework for understanding the immune system, that dates back to the mid 1970s. The symmetrical network theory is based on symmetrical stimulatory, inhibitory and killing interactions between clones that are specific for each other.
arxiv  

Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens

Biotechnology Advances
A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies targeting viral attachment and fusion glycoproteins that embellish viral particles. This observation has catalyzed the development of numerous viral glycoprotein mimetics as vaccines.
Maddy L, Newby, Joel D, Allen, Max, Crispin   +2 more
openaire   +2 more sources

Parenteral vaccination of mammalian livestock with Newcastle disease virus-based vector vaccines offers optimal efficacy and safety [PDF]

, 2011
Newcastle disease virus (NDV) is an avian virus that is being evaluated as a vaccine vector for the delivery of foreign genes in mammals. The use of NDV as a vaccine vector in these species offers two major advantages.
Antonis, A.F.G., Harmsen, M.M., Kortekaas, J.A., Moormann, R.J.M.   +3 more
core   +2 more sources

Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction

eLife, 2019
Immunotherapy, represented by immune checkpoint inhibitors (ICI), is transforming the treatment of cancer. However, only a small percentage of patients show response to ICI, and there is an unmet need for biomarkers that will identify patients who are ...
Shixiang Wang, Zaoke He, Xuan Wang, Huimin Li, Xue-song Liu   +4 more
semanticscholar   +1 more source

Countering immunotoxin immunogenicity [PDF]

British Journal of Cancer, 2016
The entry of antibody-based drugs into mainstream medicine has provided the oncologist with new therapeutic tools that have begun to transform the treatment of cancer (Scott et al, 2012; Lee et al, 2013). Toxicity profiles and cell killing mechanism(s) exhibited by antibody and small-molecule cytotoxic therapies are largely non-overlapping, thus ...
openaire   +2 more sources

Inclusion of site-specific mutations in the PB1-gene of a virulent A/WSN/33 (H1N1) strain of influenza A virus changes its phenotypic characteristics

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
Aim. Study of changes in the phenotypic characteristics of the virulent A/WSN/33 (H1N1) strain of influenza A virus under the influence of the inclusion of site-specific mutations in the PB1-gene of this strain.Materials and methods.
V. Yu. Kost, O. A. Sukhova, I. I. Akopova, E. O. Gorbacheva, K. V. Lisovskaya, A. A. Rtishchev, S. G. Markushin   +6 more
doaj   +1 more source

Satisfactory safety and immunogenicity of MSP3 malaria vaccine candidate in Tanzanian children aged 12-24 months. [PDF]

, 2009
BACKGROUND: Development and deployment of an effective malaria vaccine would complement existing malaria control measures. A blood stage malaria vaccine candidate, Merozoite Surface Protein-3 (MSP3), produced as a long synthetic peptide, has been shown ...
Bosomprah, Samuel, Chilengi, Roma, Cousens, Simon, Druilhe, Pierre, Francis, Filbert, Gesase, Samwel, Lemnge, Martha, Lusingu, John PA, Minja, Daniel, Msham, Salum, Noor, Ramadhani, Rutta, Acleus, Segeja, Method D, Sembuche, Samwel, Seth, Misago   +14 more
core   +2 more sources