Results 141 to 150 of about 364,936 (336)

Synthetic DNA immunotherapy in biochemically relapsed prostate cancer [PDF]

, 2018
Background: INO-5150 (PSA and PSMA) +/- INO-9012 (IL-12), a synthetic DNA immunotherapy, was assessed for safety, immunogenicity and efficacy in biochemically recurrent prostate cancer patients (pts).
Appleman, L. J., Bagarazzi, M. L., Bhatt, K., Cheng, H., Csiki, I., Garcia, J., Heath, E. I., Kelly, W., Kraynyak, K., Lee, J., Liu, L., McMullan, T., Morrow, M., Nordquist, L. T., Rosencranz, S., Sacchetta, B., Shore, N., Tagawa, S. T., Tutrone, R., Whang, Y.   +19 more
core   +1 more source

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine
Therapeutic antibodies are valued for their high specificity and selectivity in immunotherapy. However, the potential toxicity they may elicit underscores the necessity of assessing their preclinical efficacy and safety using suitable animal models.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
doaj   +1 more source

Tetanus and Diphtheria Toxoid-Containing Vaccine in Multiple Sclerosis Patients: A Real-World Prospective, Open-Label, Multi-Centre Study

Vaccines
Objective: To assess changes in disease activity in Multiple Sclerosis (MS) patients on various disease-modifying-drugs, as well as immunogenicity, safety and clinical tolerability following combined tetanus- and diphtheria-vaccination.
Alexander Winkelmann, Emil C. Reisinger, Katharina Boden, Christoph Metze, Uwe K. Zettl, Micha Loebermann   +5 more
doaj   +1 more source

Immunogenicity of a Bivalent Non-Purified Recombinant Vaccine against Botulism in Cattle [PDF]

, 2018
Clóvis Moreira, Marcos Roberto Alves Ferreira, Carlos Eduardo Pouey da Cunha, Rafael Amaral Donassolo, Paula Fonseca Finger, Gustavo Marçal Schmidt Garcia Moreira, Denis Y. Otaka, Loise Araújo de Sousa, José Diomedes Barbosa, Ângela Nunes Moreira, Felipe Masiero Salvarani, Fabrício Rochedo Conceição   +11 more
openalex   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Protective efficacy of inactivated FHV-1 vaccine in cats following challenge with the Chinese field strains

Frontiers in Veterinary Science
Feline herpesvirus-1 (FHV-1) is a leading cause of feline viral rhinotracheitis (FVR), which mainly presents upper respiratory tract symptoms. Vaccination is the most effective strategy for controlling FHV-1.
Yujie Jiang, Zhiying Lai, Lingling Dai, Yuan Deng, Lintao Zhong, Shoujun Li, Gang Lu   +6 more
doaj   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Response to case report: Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy

Allergy, Asthma & Clinical Immunology, 2017
I. J. Pouliquen, P. Howarth, D. Austin, G. Gunn, E. Meyer, R. G. Price, E. Bradford   +6 more
doaj   +1 more source

A Phase 1/2 Randomized Study to Evaluate the Safety, Tolerability, and Immunogenicity of Nucleoside-Modified Messenger RNA Influenza Vaccines in Healthy Adults

Vaccines
Background/Objectives: Circulating influenza strains antigenically differing from vaccine antigens increase disease burden by decreasing vaccine efficacy. Nucleoside-modified mRNA (modRNA) influenza vaccines may facilitate rapid production allowing later
Angela Branche, Mark J. Mulligan, Alok Maniar, Orlando Puente, Islamiat Oladipupo, Graham Crowther, Agnieszka M. Zareba, Zhuobiao Yi, Ingrid Scully, Emily Gomme, Kenneth Koury, Nicholas Kitchin, Pirada Suphaphiphat Allen, Annaliesa S. Anderson, Alejandra Gurtman, Kelly Lindert   +15 more
doaj   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source