Results 71 to 80 of about 598,623 (315)

Elevated serum immunoglobulin E level as a marker for progression of immunoglobulin A nephropathy

Kidney Research and Clinical Practice, 2016
Background: Immunoglobulin E (IgE) has traditionally been associated with anaphylaxis and atopic disease. Previous studies reported that serum IgE levels are elevated in nephrotic syndrome and suggested IgE levels as a prognostic indicator in glomerular ...
Ji-Hoon Lee, Shin Yeong Lee, Jin Sug Kim, Da Rae Kim, Su Woong Jung, Kyung Hwan Jeong, Tae Won Lee, Yoo Ho Lee, Yang Gyun Kim, Ju Young Moon, Sang Ho Lee, Chun Gyoo Ihm   +11 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Risk factors for severe Chlamydia pneumoniae pneumonia in children: a retrospective case–control study

Frontiers in Pediatrics
ObjectiveThis study aimed to investigate the clinical characteristics of Chlamydia pneumoniae pneumonia (CPP) in children and analyze the risk factors for progression to severe pneumonia.MethodsA total of 133 children with CPP were retrospectively ...
Di Hu, Di Hu, Yingqian Zhang, Yingqian Zhang, Yingqian Zhang, Ran Ma, Ran Ma, Chunxiao Ba, Chunxiao Ba, Peijuan Wang, Peijuan Wang   +10 more
doaj   +1 more source

Anti-inflammatory and immunomodulating effects of the bacterial lysate in the in vivo models of aseptic lymphadenitis and pneumococcal pneumonia

Медицинская иммунология, 2020
Bacterial lysates may produce immunoregulatory effects in the inflammatory diseases that are not directly caused by infectious agents; they may also stimulate the immune response against pathogens which are not a part of the lysate composition.
K. L. Kryshen, A. E. Kukharenko, A. S. Vichare, E. A. Gaidai, A. A. Kryshen, Ya. A. Gushchin, O. V. Kalyuzhin, M. N. Makarova, V. G. Makarov, B. Mahadevan   +9 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

C-myc and immunoglobulin kappa light chain constant genes are on the 8q+ chromosome of three Burkitt lymphoma lines with t(2;8) translocations [PDF]

, 1984
We have determined the localization of c-myc and the immunoglobulin kappa light chain genes on the 8q+/2p- chromosomes of the three Burkitt lymphoma lines BL21, LY66 and LY91 with t(2;8) translocation by in situ hybridization.
Cremer, Thomas, Lenoire, Gilbert M., Rappold, Gudrun A., Bornkamm, Georg W., Adolph, Sabine, Hameister, Horst, Henglein, Berthold, Freese, Ulrich-K.   +7 more
core  

Lineage tree analysis of immunoglobulin variable-region gene mutations in autoimmune diseases: chronic activation, normal selection [PDF]

, 2006
Autoimmune diseases show high diversity in the affected organs, clinical manifestations and disease dynamics. Yet they all share common features, such as the ectopic germinal centers found in many affected tissues.
Neta S. Zuckerman, Zuckerman, N.S., Michal Barak, Roshini S. Abraham, Ramit Mehr, Mehr, Ramit, Steiman-Shimony, Avital, David I. Stott, Edelman, H., Hutzler, A., Edelman, Hanna, Zuckerman, Neta S., Stott, David I., Shahaf, G., Deborah Dunn-Walters, Abraham, Roshim S., Shahaf, Gitit, Stott, D.I., Gitit Shahaf, Dunn-Walters, D., Avital Steiman-Shimony, Hutzler, Anat, Barak, M., Steiman-Shimony, A., Barak, Michal, Mehr, R., Dunn-Walters, Deborah, Anat Hutzler, Hanna Edelman, Abraham, R.S.   +29 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source