Results 61 to 70 of about 812,706 (311)

Review of Immunoinformatic approaches to in-silico B-cell epitope prediction [PDF]

, 2007
In this paper, the current state of in-silico, B-cell epitope prediction is discussed. Recommendations for improving some of the approaches encountered are outlined, along with the presentation of an entirely novel technique, which uses molecular ...
Rick Reitmaier
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Pathogenic Immunoglobulin A-Producing Cells in Immunoglobulin A Nephropathy

Journal of Clinical Medicine
Immunoglobulin A nephropathy (IgAN) is the most prevalent primary glomerular disease worldwide and it remains a leading cause of kidney failure. Clinical manifestations of IgA are exacerbated by infections, and emerging data suggest that aberrant mucosal immune responses are important contributors to the immunopathogenesis of this disease. However, the
Yuko Makita, Heather N. Reich
openaire   +2 more sources

Health-Related Quality of Life in Patients with CVID Under Different Schedules of Immunoglobulin Administration: Prospective Multicenter Study [PDF]

, 2019
We assessed the health-related quality of life (HRQoL) in CVID adults receiving different schedules of immunoglobulin replacement therapy (IgRT) by intravenous (IVIG), subcutaneous (SCIG), and facilitated (fSCIG) preparations.
Agostini, Carlo, Bonanni, Livia, Carrabba, Maria, Cinetto, Francesco, Crescenzi, Ludovica, Fabio, Giovanna, Farrugia, Albert, Milito, Cinzia, Neri, Raffaella, Pecoraro, Antonio, Pulvirenti, Federica, Quinti, Isabella, Spadaro, Giuseppe, Tabolli, Stefano   +13 more
core   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Immunoglobulin A pemphigus associated with immunoglobulin A gammopathy and lung cancer

The Journal of Dermatology, 2008
ABSTRACTImmunoglobulin (Ig)A pemphigus is a rare disease marked by a vesiculopustular eruption characterized by intercellular IgA deposition in the epidermis. It has clinical and histopathological heterogeneity and encompasses two subgroups: subcorneal pustular dermatosis type and intraepidermal neutrophilic IgA dermatosis type.
Petropoulou, Haritini, Politis, George, Panagakis, Pantelis, Hatziolou, Eftihia, Aroni, Kiriaki, Kontochristopoulos, George   +5 more
openaire   +3 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Selective Immunoglobulin A Deficiency Among Omani Patients Screened for Celiac Disease: A Cross-sectional Study

Oman Medical Journal
Objectives: Selective immunoglobulin A deficiency (SIgAD) is characterized by an isolated deficiency of serum IgA while immunoglobulin G (IgG) and immunoglobulin M (IgM) levels remain normal. Symptoms range from asymptomatic to recurrent infections.
Iman Nasr, Manal Al Kindi, Salma Al Abri, Mahmood Al Kindi, Zainab Ansari, Bushra Al Hinai, Ozay Mohamed, Salah Al Awaidy   +7 more
doaj   +1 more source

Effectiveness of Revised Trauma-Focused Cognitive Behavioral Therapy Protocol on Psychological Distress and Immunoglobulin A Concentration in Women Victims of Domestic Violence

Armaghane Danesh Bimonthly Journal, 2022
Background & aim: Domestic violence has been one of the most common social harms throughout human history, and due to its widespread effect, the pathology and treatment of this phenomenon has always been the focus of therapists. Therefore, the purpose of
SZ Kazemi Khoban, H Poursharifi, A Kakavand, M Xian Bagheri   +3 more
doaj  

Elevated serum immunoglobulin E level as a marker for progression of immunoglobulin A nephropathy

Kidney Research and Clinical Practice, 2016
Background: Immunoglobulin E (IgE) has traditionally been associated with anaphylaxis and atopic disease. Previous studies reported that serum IgE levels are elevated in nephrotic syndrome and suggested IgE levels as a prognostic indicator in glomerular ...
Ji-Hoon Lee, Shin Yeong Lee, Jin Sug Kim, Da Rae Kim, Su Woong Jung, Kyung Hwan Jeong, Tae Won Lee, Yoo Ho Lee, Yang Gyun Kim, Ju Young Moon, Sang Ho Lee, Chun Gyoo Ihm   +11 more
doaj   +1 more source