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Advances in Genetics of Immunoglobulin A Nephropathy
, 2016 Familial aggregation of IgA nephropathy (IgAN) and variation in prevalence among different ethnicities indicate inherited factors contribute to disease pathogenesis. Studies have also shown that IgAN patients also have an inherited defect in O-glycosylation of IgA1.
Zhang, Hong +2 more
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Pediatrics In Review, 2019
1. Smita Goodman, DO* 2. Jessica Reid-Adam, MD* 1. *Icahn School of Medicine at Mount Sinai, New York, NY Immunoglobulin A nephropathy (IgAN) is the most common form of primary chronic glomerular disease worldwide. First described in 1968 by pathologist Jean Berger, it was regarded for many years as a benign condition.
Smita, Goodman, Jessica, Reid-Adam
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1. Smita Goodman, DO* 2. Jessica Reid-Adam, MD* 1. *Icahn School of Medicine at Mount Sinai, New York, NY Immunoglobulin A nephropathy (IgAN) is the most common form of primary chronic glomerular disease worldwide. First described in 1968 by pathologist Jean Berger, it was regarded for many years as a benign condition.
Smita, Goodman, Jessica, Reid-Adam
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Archives of Internal Medicine, 1975
Of 475 renal biopsies examined by immunofluorescence, IgA was seen located selectively in the glomerular mesangium of 18 patients. These patients were generally young men and had hematuria, only minimal proteinuria, and normal renal function. Glomerular lesions consisted of focal segmental capillary hypercellularity or sclerosis and mesangial ...
S W, Zimmerman, P M, Burkholder
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Of 475 renal biopsies examined by immunofluorescence, IgA was seen located selectively in the glomerular mesangium of 18 patients. These patients were generally young men and had hematuria, only minimal proteinuria, and normal renal function. Glomerular lesions consisted of focal segmental capillary hypercellularity or sclerosis and mesangial ...
S W, Zimmerman, P M, Burkholder
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Pathogenesis of immunoglobulin A nephropathy
Current Opinion in Nephrology and Hypertension, 2013In this article, we review recent findings on the pathogenesis and genetics of immunoglobulin A (IgA) nephropathy.During the past 2 years, the understanding of the pathogenesis of IgA nephropathy has evolved as a result of progress in technology and new tools that have been developed.
Jan, Novak +3 more
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2009
The term immunoglobulin A nephropathy (IgA nephropathy or IgA N) refers to a primary glomerular disease characterized by the dominant or co-dominant, diffuse, and generalized mesangial deposition of IgA, often accompanied by deposition of IgG and the C3 component of complement in a similar distribution (Donadio and Grande, 2004; Barratt and Feehally ...
Richard J. Glassock, Grace Lee
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The term immunoglobulin A nephropathy (IgA nephropathy or IgA N) refers to a primary glomerular disease characterized by the dominant or co-dominant, diffuse, and generalized mesangial deposition of IgA, often accompanied by deposition of IgG and the C3 component of complement in a similar distribution (Donadio and Grande, 2004; Barratt and Feehally ...
Richard J. Glassock, Grace Lee
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Current Opinion in Nephrology and Hypertension, 1996
There is no specific treatment to reduce glomerular IgA deposition in IgA nephropathy. The available controlled trials are restricted to patients with proteinuria and progressive renal failure where mechanisms of injury are common to other chronic glomerular diseases.
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There is no specific treatment to reduce glomerular IgA deposition in IgA nephropathy. The available controlled trials are restricted to patients with proteinuria and progressive renal failure where mechanisms of injury are common to other chronic glomerular diseases.
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Pregnancy in immunoglobulin M nephropathy
Journal of Obstetrics and Gynaecology Research, 2017AbstractImmunoglobulin M nephropathy is an uncommon glomerular disease and a relatively less recognized clinico‐immunopathological entity in the domain of glomerulonephritis, often thought to be a bridge between minimal change disease and focal segmental glomerulosclerosis.
Meryem, Hocaoğlu +3 more
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Immunoglobulin A nephropathy: a pathophysiology view
Inflammation Research, 2016IgA nephropathy is one of the leading causes of primary glomerulonephritis worldwide and an important etiology of renal disease in young adults. IgA nephropathy is considered an immune complex-mediated disease.This review article summarizes recent evidence on the pathophysiology of IgA nephropathy.Current studies indicate an ordered sequence of multi ...
Rafaela Cabral Gonçalves Fabiano +2 more
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Serologic study of immunoglobulin A-fibronectin aggregates in immunoglobulin a nephropathy
American Journal of Kidney Diseases, 1996The immunoglobulin A (IgA)-fibronectin aggregates, detected by enzyme-linked immunosorbent assay using either antifibronectin or collagen I as binding protein, were previously found to be raised in the circulation of patients with IgA nephropathy (IgAN). It has been suggested that IgA-fibronectin aggregates are involved in the pathogenesis and that the
Kar Neng Lai +4 more
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Immunoglobulin A nephropathy: insights and progress
Translational Research, 2014D iseases of the kidney filter, the glomerulus, are generally recognized by clinical signs of hematuria and proteinuria. Many of these diseases can progress to cause kidney dysfunction, hypertension, andmultiple complications. In this issue of Translational Research, investigators from northeastern China present data from a large population of ...
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