Transfer of engineered biophysical properties between different antibody formats and expression systems [PDF]
, 2017 Recombinant antibodies and their derivatives are receiving ever increasing attention for many applications. Nevertheless, they differ widely in biophysical properties, from stable monomers to metastable aggregation-prone mixtures of oligomers.
Plückthun, Andreas, Schaefer, Jonas V.
core
Effects of antibodies against tubulin on the movement of reactivated sea urchin sperm flagella [PDF]
, 1980 Antibodies binding to sea urchin flagellar outer-doublet tubulin have been isolated from rabbit sera by tubulin-affinity chromatography employing electrophoretically purified tubulin as the immobilized substrate.
Asai, David J., Brokaw, Charles J.
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Clinical Practice and Cases in Emergency MedicineIntroduction: Pit viper envenomation may cause coagulopathy. The coagulopathy has been treated with crotalidae polyvalent immune fragment antigen-binding (Fab) ovine antivenom for the last few decades in the United States and usually corrects the acute ...
Jean C.Y. Lo, E. Lea Walters, Brian Wolk
doaj +1 more source
The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region. [PDF]
, 1991 A family of chimeric immunoglobulins (Igs) bearing the murine variable region directed against the hapten dansyl linked to human IgG1, -2, -3, and -4 has been characterized with respect to binding to the human high affinity Fc gamma receptor, Fc gamma RI.
Canfield, SM, Morrison, SL
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Sensing of the melanoma biomarker TROY using silicon nanowire field-effect transistors [PDF]
, 2016 Antibody-functionalized silicon nanowire field-effect transistors have been shown to exhibit excellent analyte detection sensitivity enabling sensing of analyte concentrations at levels not readily accessible by other methods.
Erramilli, Shyamsunder +5 more
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Structure of FcRY, an avian immunoglobulin receptor related to mammalian mannose receptors, and its complex with IgY [PDF]
, 2011 Fc receptors transport maternal antibodies across epithelial cell barriers to passively immunize newborns. FcRY, the functional counterpart of mammalian FcRn (a major histocompatibility complex homolog), transfers IgY across the avian yolk sac, and ...
BENNETT +22 more
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A human antibody against Zika virus crosslinks the E protein to prevent infection [PDF]
, 2017 The recent Zika virus (ZIKV) epidemic has been linked to unusual and severe clinical manifestations including microcephaly in fetuses of infected pregnant women and Guillian-Barré syndrome in adults. Neutralizing antibodies present a possible therapeutic
Crowe Jr., James E +12 more
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Prompting Fab Yeast Surface Display Efficiency by ER Retention and Molecular Chaperon Co-expression. [PDF]
, 2019 For antibody discovery and engineering, yeast surface display (YSD) of antigen-binding fragments (Fabs) and coupled fluorescence activated cell sorting (FACS) provide intact paratopic conformations and quantitative analysis at the monoclonal level, and ...
Ge, Xin +7 more
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Engineering of a recombinant fab antibody fragment against cortisol [PDF]
, 2013 The paper dwells upon the molecular cloning of genes coding the structure of mouse immunoglobulins, which can specifically bind steroid hormone cortisol.
Dormeshkin, D. O. +3 more
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Expression of Recombinant Antibodies [PDF]
, 2013 Recombinant antibodies are highly specific detection probes in research, diagnostics, and have emerged over the last two decades as the fastest growing class of therapeutic proteins.
André Frenzel +2 more
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